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CRYBA1 Antibody

  • 中文名稱(chēng):
    CRYBA1兔多克隆抗體
  • 貨號(hào):
    CSB-PA006009LA01HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Immunofluorescence staining of A549 cells with CSB-PA006009LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
    • Western blot
      All lanes: CRYBA1 antibody at 6µg/ml
      Lane 1: Human placenta tissue
      Lane 2: U251 whole cell lysate
      Lane 3: U937 whole cell lysate
      Lane 4: Mouse stomach tissue
      Lane 5: Mouse liver tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 26, 24 kDa
      Observed band size: 24 kDa
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA006009LA01HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱(chēng):
    Rabbit anti-Homo sapiens (Human) CRYBA1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CRYBA1
  • 別名:
    Beta crystallin A3 isoform A1 Delta4 form antibody; Beta crystallin A3 antibody; Beta crystallin A3 isoform A1 Delta7 form antibody; Beta crystallin A3 isoform A1 Delta8 form antibody; Beta-crystallin A3 antibody; CRBA1_HUMAN antibody; CRYB1 antibody; CRYBA1 antibody; Crystallin beta A1 antibody; Crystallin beta A3 antibody; Delta8 form antibody; Eye lens structural protein antibody; isoform A1 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Beta-crystallin A3 protein (1-215AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated

    本頁(yè)面中的產(chǎn)品,CRYBA1 Antibody (CSB-PA006009LA01HU),的標(biāo)記方式是Non-conjugated。對(duì)于CRYBA1 Antibody,我們還提供其他標(biāo)記。見(jiàn)下表:

    可提供標(biāo)記
    標(biāo)記方式 貨號(hào) 產(chǎn)品名稱(chēng) 應(yīng)用
    HRP CSB-PA006009LB01HU CRYBA1 Antibody, HRP conjugated ELISA
    FITC CSB-PA006009LC01HU CRYBA1 Antibody, FITC conjugated
    Biotin CSB-PA006009LD01HU CRYBA1 Antibody, Biotin conjugated ELISA
  • 克隆類(lèi)型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Crystallins are the dominant structural components of the vertebrate eye lens.
  • 基因功能參考文獻(xiàn):
    1. We identified a de novo in-frame 3-bp deletion in the proband with an autosomal dominant congenital cataract, but not in her parents, in an Iranian family. This mutation has occurred de novo on a paternal gamete during spermatogenesis. The in-silico results predicted the interaction of CRYBA1 protein with the other CRY as well as proteins responsible for eye cell signaling. PMID: 28120589
    2. The findings suggest that impaired endolysosomal signaling in ocular astrocytes can cause PFV disease, by adversely affecting the vascular remodeling processes essential to ocular development, including regression of the fetal vasculature. [review] PMID: 26022148
    3. association between a frameshift mutation in exon 6 of CRYBA1/A3 and congenital cataracts PMID: 24926697
    4. A novel splice site mutation in CRYBA1/A3 is associated with autosomal dominant nuclear cataracts in a Chinese family. PMID: 22665976
    5. A splice site mutation (c.215+1G>A) at the first base of intron 3 of the crystallin beta A3/A1 (CRYBA3/A1) gene has been identified in Chinese congenital polymorphic cataract patients. PMID: 22919269
    6. ThebetaA3-crystallin and betaB1-crystallin homomers and the betaA3/betaB1-crystallin heteromer all undergo similar five-state folding pathways which include one dimeric and two monomeric intermediates. PMID: 22032798
    7. A G-->T splice site mutation of CRYBA1/A3 associated with autosomal dominant suture cataracts in a Chinese family. PMID: 21850182
    8. The c.279-281delGAG mutation in CRYBA1 is responsible for the autosomal dominant congenital nuclear cataract disease in this Chinese family. PMID: 21686330
    9. A serine-type protease activity of betaA3-crystalllin was responsible for its autodegradation. PMID: 21139689
    10. This is the first report of a phenotype of progressive nuclear and cortical cataracts related to the CRYBA3/A1 mutation IVS3+1 G>A. PMID: 21139983
    11. Mutations involved in congenital cataracts and deamidation in aged lenses commonly altered protein-protein interaction between human lens betaA3-crystallins. PMID: 20300566
    12. This study is the first report relating a mutation of CRYBA1/A3 to posterior polar cataract. PMID: 20142846
    13. A deletion mutation in the betaA1/A3 crystallin gene is associated with autosomal dominant congenital nuclear cataract PMID: 14598164
    14. comprehensive description of the biophysical consequences of a mutant beta-crystallin protein that is associated with human inherited cataract. PMID: 15016766
    15. The DeltaG91 mutation in CRYBA3/A1 is associated with an autosomal dominant congenital nuclear lactescent cataract PMID: 15111599
    16. The glutamine residues at the Q180 and the Q85 were substituted with glutamic acid residues by site-directed mutagenesis. These structural changes led to decreased stability during unfolding in urea and increased precipitation during heat denaturation. PMID: 17616172
    17. Delta91 mutation arise in a relatively mutation-prone sequence of the CRYBA1 gene. PMID: 17653060
    18. Deamidation destabilizes and triggers aggregation of crystallin beta A3. PMID: 18567786
    19. mixed betaB1- and betaA3-crystallins associate predominantly into heterotetramers in equilibrium with heterodimers PMID: 18823128
    20. deamidation decreased formation of hetero-oligomers between beta-crystallin subunits; excess accumulation of deamidated beta-crystallins in vivo may disrupt normal protein-protein interactions and diminish the stabilizing effects between them PMID: 19190732
    21. Results suggest that the N-terminal arm of betaB1-crystallin interacts with betaA3-crystallin during heterooligomerization, and the solubility of betaB1-crystallin and the heterooligomer are dependent on the intact C-terminal domain of betaB1-crystallin. PMID: 19548648

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  • 相關(guān)疾病:
    Cataract 10, multiple types (CTRCT10)
  • 蛋白家族:
    Beta/gamma-crystallin family
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 2394

    OMIM: 123610

    KEGG: hsa:1411

    STRING: 9606.ENSP00000225387

    UniGene: Hs.46275



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