在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CRTC3 Antibody, Biotin conjugated

  • 中文名稱:
    CRTC3兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA747623LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CRTC3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    CREB regulated transcription coactivator 3 antibody; CREB-regulated transcription coactivator 3 antibody; CRTC 3 antibody; CRTC3 antibody; CRTC3_HUMAN antibody; FLJ21868 antibody; TORC 3 antibody; TORC-3 antibody; TORC3 antibody; Transducer of CREB protein 3 antibody; Transducer of regulated cAMP response element binding protein (CREB) 3 antibody; Transducer of regulated cAMP response element binding protein 3 antibody; Transducer of regulated cAMP response element-binding protein 3 antibody; Transducer of regulated CREB protein 3 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human CREB-regulated transcription coactivator 3 protein (373-480AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Transcriptional coactivator for CREB1 which activates transcription through both consensus and variant cAMP response element (CRE) sites. Acts as a coactivator, in the SIK/TORC signaling pathway, being active when dephosphorylated and acts independently of CREB1 'Ser-133' phosphorylation. Enhances the interaction of CREB1 with TAF4. Regulates the expression of specific CREB-activated genes such as the steroidogenic gene, StAR. Potent coactivator of PPARGC1A and inducer of mitochondrial biogenesis in muscle cells. Also coactivator for TAX activation of the human T-cell leukemia virus type 1 (HTLV-1) long terminal repeats (LTR).
  • 基因功能參考文獻:
    1. CRTC3-MAML2 gene fusion occurs in hidradenomas. PMID: 29079171
    2. CRTC3 polymorphism was associated with the onset of acute coronary syndrome in Han Chinese patients, which may be related to the imbalance of the lipid metabolism PMID: 29979427
    3. findings suggest further characterization of MECs is needed before considering the CRTC1/3-MAML2 gene fusion as a prognostic biomarker PMID: 28438292
    4. revealing neither correlation between the cellular composition and CRTC1-MAML2 fusions nor presence of CRTC3-MAML2 fusions in cutaneous hidradenoma PMID: 27402217
    5. The CRTC3 polymorphism rs3862434 is associated with the plasma level of total cholesterol, and rs11635252 is associated with the risks of overweight and hypertriglyceridemia in a Chinese Han population. PMID: 24264430
    6. Metaplastic Warthin tumor and metaplastic pleomorphic adenoma of salivary glands did not harbor CRTC1-MAML2 and CRTC3-MAML2 fusion transcripts, respectively, or MAML2 gene rearrangement. PMID: 24121173
    7. mucoepidermoid carcinoma of the salivary glands positive for CRTC1-MAML2 or CRTC3-MAML2 fusion formed a favourable tumour subset that was distinct from fusion-negative cases PMID: 21668476
    8. CRTC3 plays a selective role in mitochondrial biogenesis in response to rotenone PMID: 21536665
    9. As a common human CRTC3 variant with increased transcriptional activity is associated with adiposity in two distinct Mexican-American cohorts, results suggest that adipocyte CRTC3 may play a role in the development of obesity in humans PMID: 21164481
    10. Mucoepidermoid carcinomas possessing CRTC3-MAML2 fusion may be associated with favorable clinicopathological features and patients may be younger than those with CRTC1-MAML2 fusion or those with no detectable gene fusion. PMID: 19749740
    11. transducer of regulated cyclic AMP-response element-binding protein 3 (TORC3), a co-activator of CREB, is involved in Tax-induced transcriptional activation from the HTLV-I LTR PMID: 15466468
    12. These results strongly suggest that TORCs play a key role in linking these external signals to the transcriptional program of adaptive mitochondrial biogenesis by activating PGC-1alpha gene transcription. PMID: 16980408
    13. BCL3 functions as a repressor of HTLV-1 LTR-mediated transcription through interactions with TORC3 PMID: 17644518
    14. study reports for the first time a CRTC3-MAML2 fusion gene in a mucoepidermoid carcinoma, as determined by RT-PCR and sequencing. PMID: 18050304

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm.
  • 蛋白家族:
    TORC family
  • 組織特異性:
    Predominantly expressed in B and T lymphocytes. Highest levels in lung. Also expressed in brain, colon, heart, kidney, ovary, and prostate. Weak expression in liver, pancreas, muscle, small intestine, spleen and stomach.
  • 數據庫鏈接:

    HGNC: 26148

    OMIM: 608986

    KEGG: hsa:64784

    STRING: 9606.ENSP00000268184

    UniGene: Hs.567572



主站蜘蛛池模板: 亚洲中文字幕无码天然素人| 偷看少妇自慰xxxx| 亚洲精品一区二区丝袜图片| 无码人妻天天拍夜夜爽| 色香欲综合成人免费视频| 国产麻豆精品一区| 午夜福利体验免费体验区| 丰满无码人妻熟妇无码区| 色婷婷六月亚洲综合香蕉| 欧美性大战xxxxx久久久| 日韩高清亚洲日韩精品一区| 小鲜肉洗澡时自慰网站xnxx | 久久综合久久88中字幕文| 国自产拍偷拍精品啪啪av| 久久久亚洲欧洲日产国码aⅴ| 国产免国产免费| 免费看美女部位隐私网站| 骚动漫十八禁在线观看| 精品久久久久久| 四虎影视国产精品久久| 国产福利萌白酱精品一区| 亚洲精品成人av在线| 久久精品中文字幕无码 | 久久久精品人妻一区亚美研究所| 国内精品久久久久精免费| 男女做爰无遮挡性视频| 国产av天堂亚洲国产av下载| 第九色区av天堂| 极品嫩模高潮叫床| 亚洲欧美综合精品久久成人网| 成年入口无限观看免费完整大片| 色先锋av影音先锋在线| 国产公妇仑乱在线观看| 日日噜噜夜夜狠狠va视频| 少妇被爽到高潮动态图| 亚洲红杏成在人线免费视频| 欧美日韩国产中文高清视频| 无码无套少妇毛多18pxxxx| 久久综合激激的五月天| 亚洲国产成人精品无码区花野真一| 亚洲a∨无码一区二区三区 |