在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CRLF1 Antibody, Biotin conjugated

  • 中文名稱:
    CRLF1兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA005982LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CRLF1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CRLF1
  • 別名:
    CRLF1 antibody; UNQ288/PRO327Cytokine receptor-like factor 1 antibody; Cytokine-like factor 1 antibody; CLF-1 antibody; ZcytoR5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Cytokine receptor-like factor 1 protein (318-422AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    In complex with CLCF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). May also play a regulatory role in the immune system.
  • 基因功能參考文獻:
    1. From these results we conclude that one should consider a CRLF1-related disorder in early onset achalasia even if other Crisponi or cold-induced sweating syndrome type 1 (CS/CISS1) related symptoms are missing. PMID: 27976805
    2. we show in this series of 12 patients from four families, all previously unpublished, that the homogeneity of the recently described c.983dupG (p.Ser328Argfs *2) mutation in CRLF1 was associated with a highly variable degree of severity, and that the phenotype significantly overlaps with the recently described COG6-related anhidrosis syndrome (MIM#615328 PMID: 26804344
    3. CLF-1, based on its binding site for CLC and on two additional and independent sites for CNTFRalpha and sorLA, is a key player in CLC and CNTFRalpha signaling and turnover. PMID: 26858303
    4. Article reports 11 novel mutations in CRLF1 expanding the mutational spectrum of CRLF1 in the Crisponi/cold-induced sweating type 1 syndrome to a total of 35 variants. PMID: 24488861
    5. The mutation detected in CRLF1 has not been described in patients with CISS1, but in one with CS. These data seem to support the theory that CS and CISS1 are variants of the same disorder. PMID: 24008591
    6. Data indicate that CRLF1 serves its protective role by a cell autonomous mechanism that is independent of the gp130/JAK signaling pathway. PMID: 23818941
    7. In idiopathic pulmonary fibrosis, CLF-1 is a selective stimulus of type II alveolar epithelial cells and may potentially drive an antifibrotic response by augmenting both T-helper-1-driven and T-regulatory-cell-driven inflammatory responses in the lung. PMID: 22429962
    8. CRLF1 mutations showed that phenotypic severity of the two disorders: Crisponi syndrome (CS) and cold-induced sweating syndrome type 1 (CISS1) mainly depends on altered kinetics of secretion of the mutated CRLF1 protein. PMID: 21326283
    9. Our data suggest that the CRLF1/CLC complex disrupts cartilage homeostasis and promotes the progress of OA by enhancing the proliferation of chondrocytes and suppressing the production of cartilage matrix PMID: 19921088

    顯示更多

    收起更多

  • 相關疾病:
    Cold-induced sweating syndrome 1 (CISS1)
  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Type I cytokine receptor family, Type 3 subfamily
  • 組織特異性:
    Highest levels of expression observed in spleen, thymus, lymph node, appendix, bone marrow, stomach, placenta, heart, thyroid and ovary. Strongly expressed also in fetal lung.
  • 數據庫鏈接:

    HGNC: 2364

    OMIM: 272430

    KEGG: hsa:9244

    STRING: 9606.ENSP00000376188

    UniGene: Hs.114948



主站蜘蛛池模板: 欧美成人精精品一区二区| аⅴ天堂中文在线网| 自慰小少妇毛又多又黑流白浆| 国产综合有码无码视频在线| 国产黑色丝袜视频在线观看网红| 亚洲蜜桃v妇女| 久久99精品久久久久婷婷| 国产丝袜无码一区二区视频| 亚洲成aⅴ人最新无码 | 久热中文字幕无码视频| 中国china露脸自拍性hd| 免费人成在线观看视频播放| 国产一区二区三区在线蜜桃| 国产精品成人观看视频| 熟女少妇丰满一区二区| 春色校园综合人妻av| 中文字幕v亚洲日本在线| 男人的天堂2018无码| 久久久久国产精品嫩草影院| 亚洲精品午夜无码专区| 国产成人美女裸体片免费看| 欧美日韩亚洲中文字幕一区二区三区 | 野花社区www视频最新资源| 久久国产一区二区三区| 国产精品乱码在线观看| 国产成人啪精品视频免费视频| 大又大又粗又硬又爽少妇毛片| 国自产拍偷拍精品啪啪一区二区| 亚洲日本va午夜中文字幕久久| 欲女熟妇国产一区二区| 少妇高潮一区二区三区99| 久久久亚洲欧洲日产国码606| 四虎国产精品永久在线无码| 人妻va精品va欧美va| 四房播播开心五月| 欧美精品videossex另类日本| а√天堂8资源在线官网| 成人做受视频试看60秒| 国产亚洲精品久久久久久无| 大伊香蕉精品视频在线| 成人片黄网站色大片免费|