在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CRLF1 Antibody, Biotin conjugated

  • 中文名稱:
    CRLF1兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA005982LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CRLF1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CRLF1
  • 別名:
    CRLF1 antibody; UNQ288/PRO327Cytokine receptor-like factor 1 antibody; Cytokine-like factor 1 antibody; CLF-1 antibody; ZcytoR5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Cytokine receptor-like factor 1 protein (318-422AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    In complex with CLCF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). May also play a regulatory role in the immune system.
  • 基因功能參考文獻:
    1. From these results we conclude that one should consider a CRLF1-related disorder in early onset achalasia even if other Crisponi or cold-induced sweating syndrome type 1 (CS/CISS1) related symptoms are missing. PMID: 27976805
    2. we show in this series of 12 patients from four families, all previously unpublished, that the homogeneity of the recently described c.983dupG (p.Ser328Argfs *2) mutation in CRLF1 was associated with a highly variable degree of severity, and that the phenotype significantly overlaps with the recently described COG6-related anhidrosis syndrome (MIM#615328 PMID: 26804344
    3. CLF-1, based on its binding site for CLC and on two additional and independent sites for CNTFRalpha and sorLA, is a key player in CLC and CNTFRalpha signaling and turnover. PMID: 26858303
    4. Article reports 11 novel mutations in CRLF1 expanding the mutational spectrum of CRLF1 in the Crisponi/cold-induced sweating type 1 syndrome to a total of 35 variants. PMID: 24488861
    5. The mutation detected in CRLF1 has not been described in patients with CISS1, but in one with CS. These data seem to support the theory that CS and CISS1 are variants of the same disorder. PMID: 24008591
    6. Data indicate that CRLF1 serves its protective role by a cell autonomous mechanism that is independent of the gp130/JAK signaling pathway. PMID: 23818941
    7. In idiopathic pulmonary fibrosis, CLF-1 is a selective stimulus of type II alveolar epithelial cells and may potentially drive an antifibrotic response by augmenting both T-helper-1-driven and T-regulatory-cell-driven inflammatory responses in the lung. PMID: 22429962
    8. CRLF1 mutations showed that phenotypic severity of the two disorders: Crisponi syndrome (CS) and cold-induced sweating syndrome type 1 (CISS1) mainly depends on altered kinetics of secretion of the mutated CRLF1 protein. PMID: 21326283
    9. Our data suggest that the CRLF1/CLC complex disrupts cartilage homeostasis and promotes the progress of OA by enhancing the proliferation of chondrocytes and suppressing the production of cartilage matrix PMID: 19921088

    顯示更多

    收起更多

  • 相關疾病:
    Cold-induced sweating syndrome 1 (CISS1)
  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Type I cytokine receptor family, Type 3 subfamily
  • 組織特異性:
    Highest levels of expression observed in spleen, thymus, lymph node, appendix, bone marrow, stomach, placenta, heart, thyroid and ovary. Strongly expressed also in fetal lung.
  • 數據庫鏈接:

    HGNC: 2364

    OMIM: 272430

    KEGG: hsa:9244

    STRING: 9606.ENSP00000376188

    UniGene: Hs.114948



主站蜘蛛池模板: 无翼乌工口肉肉无遮挡无码18| 成人区人妻精品一区二区三区| 日本少妇被黑人猛cao| 女人高潮内射99精品| 国产精品无码mv在线观看| 无码精品久久一区二区三区| 中文字幕丝袜精品久久| 久久精品国产只有精品96| 丰满岳妇乱一区二区三区| 污污内射久久一区二区欧美日韩| 久久久久久欧美精品se一二三四| 国产99久久亚洲综合精品西瓜tv| 蜜芽av无码精品国产午夜| 国产剧情无码播放在线观看| 国产三级精品三级| 国产特级毛片aaaaaa毛片| 亚洲高清无在码在线电影不卡| 超级碰97直线国产免费公开| yy111111少妇影院无码| 成人无码精品1区2区3区免费看| 一性一交一口添一摸视频| 无套内谢少妇毛片aaaa片免费| 欧美精品18videos性欧美| 揉着我的奶从后面进去视频| 自愉自愉产区二十四区| 热久久99这里有精品综合久久| 国产成人一区二区三区免费| 亚洲 中文字幕 日韩 无码| 无码人妻一区二区三区一| 亚洲精品一本之道高清乱码| 日韩人妻ol丝袜av一二区| 吃奶呻吟打开双腿做受动态图| 少妇性俱乐部纵欲狂欢电影| 亚洲欧美日韩视频高清专区| 男女边吃奶边做边爱视频| 久久婷婷五月国产色综合| 中文字幕人妻熟女人妻a片| 综合激情五月综合激情五月激情1| 国产av一区二区三区最新精品| 成人网站免费大全日韩国产| 天天爱天天做久久狠狠做|