在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CRLF1 Antibody, Biotin conjugated

  • 中文名稱:
    CRLF1兔多克隆抗體, Biotin偶聯
  • 貨號:
    CSB-PA005982LD01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CRLF1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CRLF1
  • 別名:
    CRLF1 antibody; UNQ288/PRO327Cytokine receptor-like factor 1 antibody; Cytokine-like factor 1 antibody; CLF-1 antibody; ZcytoR5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Cytokine receptor-like factor 1 protein (318-422AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Biotin
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    In complex with CLCF1, forms a heterodimeric neurotropic cytokine that plays a crucial role during neuronal development (Probable). May also play a regulatory role in the immune system.
  • 基因功能參考文獻:
    1. From these results we conclude that one should consider a CRLF1-related disorder in early onset achalasia even if other Crisponi or cold-induced sweating syndrome type 1 (CS/CISS1) related symptoms are missing. PMID: 27976805
    2. we show in this series of 12 patients from four families, all previously unpublished, that the homogeneity of the recently described c.983dupG (p.Ser328Argfs *2) mutation in CRLF1 was associated with a highly variable degree of severity, and that the phenotype significantly overlaps with the recently described COG6-related anhidrosis syndrome (MIM#615328 PMID: 26804344
    3. CLF-1, based on its binding site for CLC and on two additional and independent sites for CNTFRalpha and sorLA, is a key player in CLC and CNTFRalpha signaling and turnover. PMID: 26858303
    4. Article reports 11 novel mutations in CRLF1 expanding the mutational spectrum of CRLF1 in the Crisponi/cold-induced sweating type 1 syndrome to a total of 35 variants. PMID: 24488861
    5. The mutation detected in CRLF1 has not been described in patients with CISS1, but in one with CS. These data seem to support the theory that CS and CISS1 are variants of the same disorder. PMID: 24008591
    6. Data indicate that CRLF1 serves its protective role by a cell autonomous mechanism that is independent of the gp130/JAK signaling pathway. PMID: 23818941
    7. In idiopathic pulmonary fibrosis, CLF-1 is a selective stimulus of type II alveolar epithelial cells and may potentially drive an antifibrotic response by augmenting both T-helper-1-driven and T-regulatory-cell-driven inflammatory responses in the lung. PMID: 22429962
    8. CRLF1 mutations showed that phenotypic severity of the two disorders: Crisponi syndrome (CS) and cold-induced sweating syndrome type 1 (CISS1) mainly depends on altered kinetics of secretion of the mutated CRLF1 protein. PMID: 21326283
    9. Our data suggest that the CRLF1/CLC complex disrupts cartilage homeostasis and promotes the progress of OA by enhancing the proliferation of chondrocytes and suppressing the production of cartilage matrix PMID: 19921088

    顯示更多

    收起更多

  • 相關疾病:
    Cold-induced sweating syndrome 1 (CISS1)
  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Type I cytokine receptor family, Type 3 subfamily
  • 組織特異性:
    Highest levels of expression observed in spleen, thymus, lymph node, appendix, bone marrow, stomach, placenta, heart, thyroid and ovary. Strongly expressed also in fetal lung.
  • 數據庫鏈接:

    HGNC: 2364

    OMIM: 272430

    KEGG: hsa:9244

    STRING: 9606.ENSP00000376188

    UniGene: Hs.114948



主站蜘蛛池模板: а天堂中文在线官网在线| 波多老师无码av中字专区 | 亚洲 自拍 另类小说综合图区| 综合激情久久综合激情| 2020国产激情视频在线观看| 国产精品视频一区二区三区不卡| 99草草国产熟女视频在线| 天天综合亚洲色在线精品| 天天爽天天狠久久久综合麻豆| 夜夜躁狠狠躁日日躁视频| 国产乱人伦偷精品视频| 亚洲 欧美 成人 自拍 高清| 亚洲一区二区无码影院| 亚洲 日本 欧美 中文幕 | 精品丰满人妻无套内射| 亚洲国产精品国自产拍av| 日日碰狠狠躁久久躁96| 日韩~欧美一中文字幕| 成人无码免费一区二区三区| 日韩精品乱码av一区二区 | 亚洲中文字幕无码人在线| 亚洲a∨精品无码一区二区| 无码国产成人午夜电影在线观看| 2018国产精华国产精品| 午夜尤物禁止18点击进入| 人妻插b视频一区二区三区| 久久久久黑人强伦姧人妻| 疯狂做受xxxx高潮欧美日本| 性av盈盈无码天堂| 国产精品99久久久久久宅男| 大伊香蕉精品视频在线天堂| 成人无码嫩草影院| 亚洲综合久久成人a片| 奇米影视第4色| 日韩无套内射视频6| 波多野结衣av高清一区二区三区 | 亚洲风情亚aⅴ在线发布| 国产乱妇乱子在线播放视频| 亚洲乱码中文论理电影| 亚洲精品一区二区三区中文字幕| 久久精品无码一区二区三区|