在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CRK Antibody

  • 中文名稱:
    CRK兔多克隆抗體
  • 貨號:
    CSB-PA001789
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of COS7 cells using Crk II Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Adapter molecule crk antibody; Avian sarcoma virus CT10 (v crk) oncogene homolog antibody; CRK antibody; CRK isoform 2 antibody; CRK isoform II antibody; CRK_HUMAN antibody; CRKII antibody; FLJ38130 antibody; OTTHUMP00000115366 antibody; OTTHUMP00000198330 antibody; p38 antibody; Proto oncogene C crk antibody; Proto-oncogene C-crk antibody; v crk avian sarcoma virus CT10 oncogene homolog antibody; v crk sarcoma virus CT10 oncogene homolog antibody; v crk sarcoma virus CT10 oncogene homolog (avian) antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat,Monkey
  • 免疫原:
    Synthesized peptide derived from Human Crk II around the non-phosphorylation site of Y221.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, IF, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    IF 1:200-1:1000
    ELISA 1:5000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Involved in cell branching and adhesion mediated by BCAR1-CRK-RAPGEF1 signaling and activation of RAP1.; Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.
  • 基因功能參考文獻:
    1. A reduced miR-126 expression and an elevated Crk protein expression, alone or in combination, statistically correlated with aggressive clinicopathological characteristics, such as larger tumor size, deeper local invasion, more lymph node metastasis, advanced TNM stage, and poorer prognosis. PMID: 29171987
    2. these data highlight a signaling pathway in which SHP-1 acts through CrkII to reshape the pattern of Rap1 activation in the immunological synapse. PMID: 28790195
    3. Crk-dependent increased phosphorylation of CD3zeta coincided with inhibition of TCR downmodulation, supporting a positive role for Crk adaptor proteins in TCR-mediated signal amplification. PMID: 28465009
    4. This mini review will focus on the emerging roles of Crk adaptors during myocardial I/R injury. PMID: 28553779
    5. TGF-beta and Crk collaborate to form a positive feedback loop to facilitate epithelial-mesenchymal transition (EMT). PMID: 27027347
    6. The results suggest the involvement of Crk adaptor proteins in the early stages of T cell activation in which Crk might help recruiting effector proteins to the vicinity of the phospho-CD3zeta and contribute to the fine-tuning of the TCR/CD3-coupled signal transduction pathways. PMID: 28526413
    7. Study investigated structures and thermodynamics of the interactions mediated by N-terminal Src homology 3 domain of CrkII and proline-rich motifs (PRMs) of cAbl kinase, highlight the role of interfacial water molecules and the conformational entropy in the SH3:PRM interactions PMID: 27332121
    8. CrkII mediates IGF-1 signaling and further balances pancreatic ductal adenocarcinoma biological behaviors via Erk1/2 and Akt pathway PMID: 26250463
    9. In individuals with class I 17p13.3 microduplications including CRK, we recommend biochemical evaluation of the growth hormone axis. Providers caring for these patients should be aware of their possible risk for the development of central precocious puberty. PMID: 27633569
    10. Crk Tyr251 phosphorylation regulate invasive cell phenotypes in glioblastoma. PMID: 26473374
    11. CsA and FK506 might interfere with selected effector T cell functions via a CrkII-, but not CrkI-dependent mechanisms. PMID: 26792730
    12. Studied the role of PAK1/Crk axis in transduction of the oncogenic KRAS signal in non-small cell lung cancer (NSCLC). PMID: 25956913
    13. in human c-CrkII, movement at position 239 and strain at position 272 are not tolerated because the beta-branched residues Ile239 and Val272 restrain the backbone mobility and thus destabilize the cis Pro238 form. PMID: 26456136
    14. Data indicate the role of tyrosine phosphorylation in regulating modular domain utilization in v-crk sarcoma virus CT10 oncogene homolog (avian) protein (Crk). PMID: 25381819
    15. evidence uncovered essential roles of CRK in invasive bladder cancer through the hepatocyte growth factor/c-Met/CRK feedback loop for epithelial-mesenchymal transition induction PMID: 25816892
    16. In this review, we describe the structure and function of the different Crk proteins. PMID: 25506591
    17. proline switch and its role in Crk signaling PMID: 24702481
    18. Data indicate that human proto-oncogene c-CrkII (CrkII) is regulated by phosphorylation only, but chicken CrkII is regulated by Pro238 trans-->cis isomerization and by Tyr222 phosphorylation. PMID: 25284755
    19. Study indicates that miR-126 is a tumor suppressor that inhibits gastric cancer cells proliferation by targeting PI3KR2, Crk and PLK2. PMID: 24969300
    20. Crk1/2 and CrkL are physically linked, functionally complement each other during podocyte foot process spreading, and together are required for developing typical foot process architecture. PMID: 24499776
    21. The present data demonstrate that immunophilins regulate CrkII, but not CrkI activity in T cells and suggest that CsA and FK506 inhibit selected effector T cell functions via a CrkII-dependent mechanism. PMID: 25225668
    22. This study analyzed the kinetics of folding and substrate binding of the two homologues and found that cis-trans isomerization of Pro238 determines target binding in chicken but not in human CT10 regulator of kinase protein (c-CrkII). PMID: 24571054
    23. We propose that Crk adaptor proteins inhibit actin polymerization by competing with Nck binding to Tir. PMID: 24675776
    24. This prospect summarizes recent developments in Crk biology, including new structural and biochemical roles for the atypical carboxyl-terminal SH3 (SH3C) domain. PMID: 24356912
    25. These findings suggest that PTPN4 negatively regulates cell proliferation and motility through dephosphorylation of CrkI. PMID: 23666597
    26. P-glycoprotein activity in association with pCrkl reduction levels might help to distinguish between imatinib-resistant and imatinib-sensitive chronic myeloid leukemia cells. PMID: 24210993
    27. A gene signature derived following CrkII over-expression correlated significantly with basal breast cancers and with high grade and poor outcome in general; data highlight the physiological importance of Crk proteins in regulating growth of aggressive basal breast cancer cells PMID: 22569336
    28. the role of PAK1 in the promotion of cell motility, cell invasiveness and the down regulation of p120-catenin through CRK serine 41 phosphorylation in NSCLC cells PMID: 22848689
    29. SRC, c-MET and CRK play a key role in gastric carcinogenesis by modulating CagA signal transductions and interaction between CRK gene and phytoestrogens modify gastric cancer risk PMID: 22383989
    30. miR-126 may play an initial role in the development and progression of EMs. Crk may be regulated by miR-126, and synergism between abnormal expressions may play an important role in the pathogenesis of EMs. PMID: 22012249
    31. propose a unified model for inhibitory receptor function: Crk phosphorylation prevents essential Crk-dependent activation signals and blocks F-actin network formation, thereby reducing constraints on subsequent engagement of activation receptors PMID: 22464172
    32. CrkI and p130(Cas) complex regulates the migration and invasion of prostate cancer cells. PMID: 22144090
    33. positive regulatory role resulting from tyrosine phosphorylation of Crk, and identify a novel mechanism by which an adaptor protein activates a non-receptor tyrosine kinase by SH2 domain displacement PMID: 21602891
    34. differential binding selectivity of Crk and CrkL to their downstream partners Dock 180 and C3G was demonstrated in ovarian cancer cell line SKOV3 through coimmunoprecipitation PMID: 21319228
    35. CRKII increases migration and invasive potential in oral squamous cell carcinoma PMID: 21339045
    36. SOS1 is essential for CrkI-induced fibroblast transformation, and also reveal a surprising negative role for Abl kinases in Crk transformation. PMID: 20729917
    37. These results imply that binding capacity of influenza A virus NS1 to CRK/CRKL has evolved in virus strains that over-induce the antiviral acting JNK-ATF2 signalling module and helps to suppress the detrimental apoptosis promoting action of this pathway. PMID: 20088952
    38. signal transfer of Crk/Dock180/Rac1 is implicated in actin cytoskeleton reorganization and thus in the cell proliferation, motility, invasion, and of human ovarian cancer cell line SKOV3. PMID: 20237902
    39. Silencing of CRK-I/II increased endothelial cell migration. PMID: 19760510
    40. Depletion of Crk by RNA interference markedly inhibited proliferation of the synovial sarcoma cell lines HS-SYII, SYO-1, and Fuji as well as prevented anchorage-independent growth. PMID: 19737974
    41. Molecular and immunohistochemical analysis of signaling adaptor protein Crk in human cancers PMID: 11911970
    42. determined the NMR solution structure of the ternary complex of the Abl SH3 domain with the Crk SH2 domain bound to a Crk pY221 phosphopeptide PMID: 12384576
    43. Crk plays a critical role in Rac1-induced membrane ruffling and Rap1-mediated nascent focal complex stabilization contributing to ephrin-B1-induced human aortic endothelial cells migration PMID: 12475948
    44. Requirement of the p130CAS-Crk coupling for metastasis suppressor KAI1/CD82-mediated inhibition of cell migration in a metastatic prostate cancer cell line. PMID: 12738793
    45. CRK is ADP ribosylated by Pseudomonas aeruginosa ExoT, demonstrating how ADP-ribosylation of Crk-I may be responsible for the anti-phagocytosis phenotype elicited by ExoT in mammalian cells PMID: 12807879
    46. c-Src phosphorylates the receptor KIT, thereby creating docking sites for SH2 domain containing proteins, leading to recruitment of Crk to the receptor. PMID: 12878163
    47. This study provides the first quantitative analysis of discrete CRKI and CRKII protein isoforms in human lung tumors and provides evidence that the C-CRK proto-oncogene may foment a more aggressive phenotype in lung cancers. PMID: 12970743
    48. Nck and Crk mediate distinct VEGF-induced signaling pathways that serve overlapping functions in cell migration. PMID: 15051508
    49. a major role for a Crk-cortactin complex in actin polymerization downstream of tyrosine kinase signaling PMID: 15263018
    50. Crk may be involved in regulation of cell motility by a hyaluronic acid-dependent mechanism through an association with ERMs PMID: 15326184

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Cell membrane.
  • 蛋白家族:
    CRK family
  • 數據庫鏈接:

    HGNC: 2362

    OMIM: 164762

    KEGG: hsa:1398

    STRING: 9606.ENSP00000300574

    UniGene: Hs.461896



主站蜘蛛池模板: 国自产拍偷拍精品啪啪一区二区 | 成人做爰www网站视频| 韩国精品一区二区三区四区 | 亚洲午夜成人精品无码| 亚洲国产区男人本色| 国产sm调教视频在线观看| 国产绳艺sm调教室论坛| 人人爽人人爽人人片av免费| 国内少妇高潮嗷嗷叫在线播放| 久久久一本精品99久久精品88 | 激情按摩系列片aaaa| 国内女人喷潮完整视频| 精品人妻伦一二三区久久| 日日做夜狠狠爱欧美黑人| 亚洲最大成人网 色香蕉| 国产乱子伦精品无码码专区| 最新亚洲人成网站在线观看| 亚洲αⅴ无码乱码在线观看性色| 国产精品成人片在线观看| 中文字幕亚洲男人的天堂网络| 亚洲精品成人av在线| 中年熟妇的大黑p| 亚洲欧美成人a∨观看| 狠狠色噜噜狠狠狠狠米奇777| 丝袜美腿亚洲一区二区| 国产精品偷窥熟女精品视频 | 婷婷五月综合激情中文字幕| 亚洲欧洲自拍拍偷精品网| 国产在线观看www污污污| 亚洲人成在线影院| 18禁黄无遮挡网站免费| 奇米777四色成人影视| 亚洲精品无播放器在线播放| 18禁网站免费无遮挡无码中文| 精品国产美女av久久久久| 色偷偷人人澡久久超碰97| 国内精品久久久久av福利秒拍| 综合网日日天干夜夜久久| 777精品久无码人妻蜜桃| 非洲黑人性xxxx精品| 亚洲综合激情七月婷婷|