在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CREG1 Antibody

  • 中文名稱:
    CREG1兔多克隆抗體
  • 貨號:
    CSB-PA005957GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Cellular repressor of E1A stimulated genes 1 antibody; Cellular repressor of E1A-stimulated genes 1 antibody; CREG antibody; CREG1 antibody; CREG1_HUMAN antibody; Protein CREG1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human CREG1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.
  • 基因功能參考文獻:
    1. Studies demonstrated that CREG may modulate homeostasis of vascular wall cells and inhibit inflammation of vascular tissue cells and macrophages. Mechanistically, CREG behaves like a typical soluble lysosomal protein that regulates the formation and maturation of lysosomes by modulating the small GTPase protein Rab7, to mediate autophagy in vascular vascular tissue cells. [review] PMID: 27784214
    2. These results indicate that CREG1 is a down-stream effector of KRAS in a sub-type of non-small cell lung cancer cells and a novel candidate biomarker or therapeutic target for KRAS mutant non-small cell lung cancer. PMID: 26722374
    3. Results indicate that cellular repressor of E1A-stimulated gene 1 protein (CREG1) increases endothelial cell (EC) filopodia formation. PMID: 24896341
    4. The results suggest a novel role of CREG to promote HUVEC proliferation through the ERK/cyclin E signaling pathway. PMID: 24018888
    5. CREG can inhibit NF-kappaB activation, TNF-alpha-induced inflammatory responses and the hyperpermeability of endothelial cells. PMID: 23580165
    6. miR-31 not only directly binds to its target gene CREG and modulates the vascular smooth muscle cells(VSMC) phenotype through this interaction, but also can be an important biomarker in diseases involving VSMC phenotypic modulation. PMID: 23518389
    7. Suggest that CREG is a novel adventitial fibroblast phenotypic modulator in a p38MAPK-dependent manner. PMID: 23040447
    8. Upregulation of CREG expression induced HUVEC migration. PMID: 21939655
    9. Cooperation of CREG1 and p16 (INK4a) inhibits the expression of cyclin A and cyclin B by inhibiting promoter activity thereby decreasing mRNA and protein levels; these proteins are required for S-phase entry and G2/M transition. PMID: 21263217
    10. Data suggest that soluble CREG protein can exert its biological function via glycosylation-independent binding to the extracellular domains 11-13 of cell surface M6P/IGF2R, modulating SMC phenotypic switching from contractile to proliferative. PMID: 21195083
    11. no ssociation between common variants of CREG and coronary artery disease in the northern Chinese Han population PMID: 20951690
    12. CREG plays a key role in modulating VSMC apoptosis through the p38 and JNK signal transduction pathways, both in vitro and in s PMID: 20060003
    13. CREG plays a critical role in the inhibition of SMC migration, as well as maintaining SMCs in a mature phenotype PMID: 19769965
    14. putative flavin mononucleotide-binding pocket in CREG is sterically blocked by a loop and several key bulky residues PMID: 16344469
    15. CREG promotes a mature smooth muscle cell phenotype and reduces neointimal formation in balloon-injured rat carotid artery. PMID: 18267954
    16. We demonstrate that CREG is expressed in the vascular endothelium; data suggests that CREG differentially regulates the growth of the denuded artery wall and smooth vascular muscle cell. PMID: 18472385
    17. The expression of CREG improves cardiac functions and inhibits cardiac hypertrophy, inflammation and fibrosis through blocking MEK-ERK1/2-dependent signalling. PMID: 19413895

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    CREG family
  • 數據庫鏈接:

    HGNC: 2351

    KEGG: hsa:8804

    STRING: 9606.ENSP00000359540

    UniGene: Hs.5710



主站蜘蛛池模板: 日本丰满老妇bbw| 免费的av网站手机版| 欧美日产欧美日产国产精品| 亚洲精品国产高清一线久久| 国产草草影院ccyycom| 国产精品18久久久久久vr| 春色校园综合人妻av| 亚洲va久久久噜噜噜久久4399| 女人裸露免费视频无遮挡网站| 少妇被黑人4p到惨叫欧美人| 久久国产亚洲精品无码| 久久伊人蜜桃av一区二区| 成人午夜高潮a∨猛片| 人妻精品久久久久中文字幕 | 性欧美高清come| av无码一区二区大桥久未| 天堂а√在线最新版中文| 国产一区视频一区欧美| 成年午夜无码av片在线观看| 永久黄网站色视频免费| 亚洲精品乱码久久久久久蜜桃不卡| 爆乳护士一区二区三区在线播放| 人妻熟妇乱又伦精品视频无广告| 亚洲精品久久久久久中文传媒| 国产精品久久国产三级国 | 热99re久久精品国产首页免费| 四虎www永久在线精品| 两性色午夜免费视频| 性人久久久久| 久久国产美女精品久久| 天堂久久天堂av色综合| 久久精品国产亚洲αv忘忧草| 国模丽丽啪啪一区二区| 少妇性l交大片| 人人玩人人添人人澡| 国内精品久久久久久影院8f| 色偷偷人人澡人人爽人人模 | 天堂网在线最新版www中文网| 西西艺术人像摄影| 在线观看成人无码中文av天堂| 亚洲人成无码网站久久99热国产|