在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CREG1 Antibody

  • 中文名稱:
    CREG1兔多克隆抗體
  • 貨號:
    CSB-PA005957GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Cellular repressor of E1A stimulated genes 1 antibody; Cellular repressor of E1A-stimulated genes 1 antibody; CREG antibody; CREG1 antibody; CREG1_HUMAN antibody; Protein CREG1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human CREG1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.
  • 基因功能參考文獻:
    1. Studies demonstrated that CREG may modulate homeostasis of vascular wall cells and inhibit inflammation of vascular tissue cells and macrophages. Mechanistically, CREG behaves like a typical soluble lysosomal protein that regulates the formation and maturation of lysosomes by modulating the small GTPase protein Rab7, to mediate autophagy in vascular vascular tissue cells. [review] PMID: 27784214
    2. These results indicate that CREG1 is a down-stream effector of KRAS in a sub-type of non-small cell lung cancer cells and a novel candidate biomarker or therapeutic target for KRAS mutant non-small cell lung cancer. PMID: 26722374
    3. Results indicate that cellular repressor of E1A-stimulated gene 1 protein (CREG1) increases endothelial cell (EC) filopodia formation. PMID: 24896341
    4. The results suggest a novel role of CREG to promote HUVEC proliferation through the ERK/cyclin E signaling pathway. PMID: 24018888
    5. CREG can inhibit NF-kappaB activation, TNF-alpha-induced inflammatory responses and the hyperpermeability of endothelial cells. PMID: 23580165
    6. miR-31 not only directly binds to its target gene CREG and modulates the vascular smooth muscle cells(VSMC) phenotype through this interaction, but also can be an important biomarker in diseases involving VSMC phenotypic modulation. PMID: 23518389
    7. Suggest that CREG is a novel adventitial fibroblast phenotypic modulator in a p38MAPK-dependent manner. PMID: 23040447
    8. Upregulation of CREG expression induced HUVEC migration. PMID: 21939655
    9. Cooperation of CREG1 and p16 (INK4a) inhibits the expression of cyclin A and cyclin B by inhibiting promoter activity thereby decreasing mRNA and protein levels; these proteins are required for S-phase entry and G2/M transition. PMID: 21263217
    10. Data suggest that soluble CREG protein can exert its biological function via glycosylation-independent binding to the extracellular domains 11-13 of cell surface M6P/IGF2R, modulating SMC phenotypic switching from contractile to proliferative. PMID: 21195083
    11. no ssociation between common variants of CREG and coronary artery disease in the northern Chinese Han population PMID: 20951690
    12. CREG plays a key role in modulating VSMC apoptosis through the p38 and JNK signal transduction pathways, both in vitro and in s PMID: 20060003
    13. CREG plays a critical role in the inhibition of SMC migration, as well as maintaining SMCs in a mature phenotype PMID: 19769965
    14. putative flavin mononucleotide-binding pocket in CREG is sterically blocked by a loop and several key bulky residues PMID: 16344469
    15. CREG promotes a mature smooth muscle cell phenotype and reduces neointimal formation in balloon-injured rat carotid artery. PMID: 18267954
    16. We demonstrate that CREG is expressed in the vascular endothelium; data suggests that CREG differentially regulates the growth of the denuded artery wall and smooth vascular muscle cell. PMID: 18472385
    17. The expression of CREG improves cardiac functions and inhibits cardiac hypertrophy, inflammation and fibrosis through blocking MEK-ERK1/2-dependent signalling. PMID: 19413895

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    CREG family
  • 數據庫鏈接:

    HGNC: 2351

    KEGG: hsa:8804

    STRING: 9606.ENSP00000359540

    UniGene: Hs.5710



主站蜘蛛池模板: 久久久久亚洲精品| 亚洲国产精品久久精品| 亚洲综合一区二区三区无码| 亚洲国产av无码精品无广告| 国产拍拍拍无码视频免费| 双腿张开被9个男人调教| 国产精品国产亚洲区艳妇糸列短篇| 日韩a毛片免费观看| 乱色国内精品视频在线| 国产成人一区二区三区app| 亚洲一区二区三区小说| 亚洲熟女乱色综合亚洲图片 | 亚洲乱码中文字幕久久孕妇黑人| 精品国精品自拍自在线| 国产精品卡1卡2卡3网站| 无码免费中文字幕视频| 国产精品区av| 国产白袜脚足j棉袜在线观看| 亚洲国产精品久久网午夜| 四虎亚洲精品高清在线观看| 老湿机香蕉久久久久久| 久久久亚洲精品一区二区三区浴池| 色综合久久蜜芽国产精品| 边吃奶边添下面好爽| 欧美成人看片一区二三区图文| 巨爆乳中文字幕巨爆区巨爆乳无码 | 三级做爰高清视频| 国产95在线 | 亚洲| 久久综合狠狠色综合伊人| av无码人妻一区二区三区牛牛| 午夜免费啪视频在线观看区| 国农村精品国产自线拍| 再深点灬舒服灬太大了网站| 熟睡人妻被讨厌的公侵犯深田咏美| 午夜伦4480yy私人影院| 最激烈的床震娇喘视频出水| 色欲综合一区二区三区| 亚洲中文字幕久久无码| 国产亚洲产品影视在线产品| 少妇呻吟白浆高潮啪啪69| 99久久亚洲精品无码毛片|