在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CREG1 Antibody

  • 中文名稱:
    CREG1兔多克隆抗體
  • 貨號:
    CSB-PA005957GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Cellular repressor of E1A stimulated genes 1 antibody; Cellular repressor of E1A-stimulated genes 1 antibody; CREG antibody; CREG1 antibody; CREG1_HUMAN antibody; Protein CREG1 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human CREG1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May contribute to the transcriptional control of cell growth and differentiation. Antagonizes transcriptional activation and cellular transformation by the adenovirus E1A protein. The transcriptional control activity of cell growth requires interaction with IGF2R.
  • 基因功能參考文獻:
    1. Studies demonstrated that CREG may modulate homeostasis of vascular wall cells and inhibit inflammation of vascular tissue cells and macrophages. Mechanistically, CREG behaves like a typical soluble lysosomal protein that regulates the formation and maturation of lysosomes by modulating the small GTPase protein Rab7, to mediate autophagy in vascular vascular tissue cells. [review] PMID: 27784214
    2. These results indicate that CREG1 is a down-stream effector of KRAS in a sub-type of non-small cell lung cancer cells and a novel candidate biomarker or therapeutic target for KRAS mutant non-small cell lung cancer. PMID: 26722374
    3. Results indicate that cellular repressor of E1A-stimulated gene 1 protein (CREG1) increases endothelial cell (EC) filopodia formation. PMID: 24896341
    4. The results suggest a novel role of CREG to promote HUVEC proliferation through the ERK/cyclin E signaling pathway. PMID: 24018888
    5. CREG can inhibit NF-kappaB activation, TNF-alpha-induced inflammatory responses and the hyperpermeability of endothelial cells. PMID: 23580165
    6. miR-31 not only directly binds to its target gene CREG and modulates the vascular smooth muscle cells(VSMC) phenotype through this interaction, but also can be an important biomarker in diseases involving VSMC phenotypic modulation. PMID: 23518389
    7. Suggest that CREG is a novel adventitial fibroblast phenotypic modulator in a p38MAPK-dependent manner. PMID: 23040447
    8. Upregulation of CREG expression induced HUVEC migration. PMID: 21939655
    9. Cooperation of CREG1 and p16 (INK4a) inhibits the expression of cyclin A and cyclin B by inhibiting promoter activity thereby decreasing mRNA and protein levels; these proteins are required for S-phase entry and G2/M transition. PMID: 21263217
    10. Data suggest that soluble CREG protein can exert its biological function via glycosylation-independent binding to the extracellular domains 11-13 of cell surface M6P/IGF2R, modulating SMC phenotypic switching from contractile to proliferative. PMID: 21195083
    11. no ssociation between common variants of CREG and coronary artery disease in the northern Chinese Han population PMID: 20951690
    12. CREG plays a key role in modulating VSMC apoptosis through the p38 and JNK signal transduction pathways, both in vitro and in s PMID: 20060003
    13. CREG plays a critical role in the inhibition of SMC migration, as well as maintaining SMCs in a mature phenotype PMID: 19769965
    14. putative flavin mononucleotide-binding pocket in CREG is sterically blocked by a loop and several key bulky residues PMID: 16344469
    15. CREG promotes a mature smooth muscle cell phenotype and reduces neointimal formation in balloon-injured rat carotid artery. PMID: 18267954
    16. We demonstrate that CREG is expressed in the vascular endothelium; data suggests that CREG differentially regulates the growth of the denuded artery wall and smooth vascular muscle cell. PMID: 18472385
    17. The expression of CREG improves cardiac functions and inhibits cardiac hypertrophy, inflammation and fibrosis through blocking MEK-ERK1/2-dependent signalling. PMID: 19413895

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    CREG family
  • 數據庫鏈接:

    HGNC: 2351

    KEGG: hsa:8804

    STRING: 9606.ENSP00000359540

    UniGene: Hs.5710



主站蜘蛛池模板: 日本高清va在线播放| 亚洲 中文 欧美 日韩 在线| av成人无码无在线观看| 国产 精品 自在 线免费 | 日韩a片无码一区二区三区电影| 久久青青草免费线频观| 夫妇交换性三中文字幕| 欧美激情一区二区三区| 女狠狠噜天天噜日日噜| 丰满人妻熟妇乱又仑精品| 日韩欧美亚洲综合久久| 久久九九精品99国产精品 | 国产99视频精品免费视看9| 日本一卡2卡3卡4卡5卡精品视频| 中国精学生妹品射精久久| 色吊丝av中文字幕| 中国性少妇内射xxxx狠干| 中国少妇内射xxxxx-百度 | 国产亚洲精品久久久久秋霞不卡 | 国产精品原创巨作av| 亚洲欧洲日产国码韩国| 米奇影院888奇米色99在线| 人妻熟女一区二区aⅴ千叶宁真| 国产人澡人澡澡澡人碰视频| 国产精品国产三级国产av麻豆| 亚洲aⅴ天堂av天堂无码| 亚洲乱码国产乱码精品精| 亚洲性夜夜天天天| 国产男女嘿咻视频在线观看| 天天狠天天透天干天天怕∴| 97视频在线观看播放| 12裸体自慰免费观看网站| 久久久久国产精品人妻aⅴ果冻 | 国产亚洲精品久久久久的角色| 日本大乳高潮视频在线观看| 麻豆av字幕无码中文| 性色香蕉av久久久天天网| 妺妺窝人体色www看美女| 十八禁真人啪啪免费网站| 亚洲另类欧美综合久久图片区| 综合 欧美 亚洲日本|