在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CRADD Antibody

CRADD Antibody

  • 中文名稱：
    CRADD兔多克隆抗體
  • 貨號：
    CSB-PA005938ESR1HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA005938ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA005938ESR1HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CRADD Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CRADD
  • 別名：
    CASP2 and RIPK1 domain containing adaptor with death domain antibody; Caspase and RIP adapter with death domain antibody; Caspase and RIP adaptor with death domain antibody; Cradd antibody; CRADD_HUMAN antibody; Death adaptor molecule RAIDD antibody; Death domain containing protein CRADD antibody; Death domain-containing protein CRADD antibody; MGC9163 antibody; RIP associated ICH1/CED3 homologous protein with death domain antibody; RIP associated protein with a death domain antibody; RIP-associated protein with a death domain antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Death domain-containing protein CRADD protein (1-199AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Adapter protein that associates with PIDD1 and the caspase CASP2 to form the PIDDosome, a complex that activates CASP2 and triggers apoptosis. Also recruits CASP2 to the TNFR-1 signaling complex through its interaction with RIPK1 and TRADD and may play a role in the tumor necrosis factor-mediated signaling pathway.
  • 基因功能參考文獻：
    1. Whole exome sequencing (WES) of an affected fetus, and subsequent Sanger sequencing of the second fetus, revealed a homozygous frameshift variant in CRADD, which encodes an adaptor protein that interacts with PIDD and caspase-2 to initiate apoptosis PMID: 28686357
    2. The megalencephaly, lissencephaly variant, and intellectual disability associated with loss of CRADD/caspase-2-mediated apoptosis imply a role for CRADD/caspase-2 signaling in development of the human cerebral cortex. PMID: 27773430
    3. The adaptor molecule RAIDD coordinates IKKepsilon and IRF7 interaction to ensure efficient expression of type I interferon. PMID: 27606466
    4. define a novel function for CRADD in endothelial cells as an inducible suppressor of BCL10, a key mediator of responses to proinflammatory agonists PMID: 24958727
    5. Crystals are trigonal and belong to space group P3(1)21 (or its enantiomorph P3(2)21) with unit-cell parameters a = 56.3, b = 56.3, c = 64.9 A and gamma = 120 degrees . PMID: 19582216
    6. Study identified sequence variants in the known disease-causing genes SLC6A3 and FLVCR1, and present evidence to strongly support the pathogenicity of variants identified in TUBGCP6, BRAT1, SNIP1, CRADD, and HARS. PMID: 22279524
    7. point mutations on RAIDD (R147E) and on PIDD (Y814A) exert a dominant negative effect on the formation of the PIDDosome, and that this effect cannot be applied after the PIDDosome has been formed PMID: 20406701
    8. The expressions of PIDD and RAIDD are upregulated during tumour progression in renal cell carcinomas. PMID: 20208132
    9. As a first step towards elucidating the molecular mechanisms of caspase-2 activation, data report the crystal structure of the RAIDD death domain at 2.0 A resolution. PMID: 16434054
    10. PIDD death domain (DD) and RAIDD DD assemble into an oligomeric complex. Within the PIDDosome, the interaction between PIDD and RAIDD is mediated by a homotypic interaction between their death domains. PMID: 17329820
    11. impaired expression of RAIDD in drug induced apoptosis may play a role in the multidrug resistance of osteosarcoma cells PMID: 19125251

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Mental retardation, autosomal recessive 34, with variant lissencephaly (MRT34)
  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 組織特異性：
    Constitutively expressed in most tissues, with particularly high expression in adult heart, testis, liver, skeletal muscle, fetal liver and kidney.
  • 數據庫鏈接：

    HGNC: 2340

    OMIM: 603454

    KEGG: hsa:8738

    STRING: 9606.ENSP00000327647

    UniGene: Hs.38533



主站蜘蛛池模板： 骚片av蜜桃精品一区| 国产佗精品一区二区三区| 国产精品揄拍100视频| 国产性生交xxxxx免费| 日韩人妻无码精品一专区| 日本久久夜夜一本婷婷| 国产精品丝袜高跟鞋| 人妻体体内射精一区二区| 午夜福利麻豆国产精品| 久久99国产综合精品女同| 中文字幕人妻熟在线影院| 免费无码又爽又刺激高潮的视频| 在线精品一区二区三区| 夜夜春亚洲嫩草影院| 亚洲伊人久久成人综合网| 欧美性猛交aaaa片黑人| 精品国产精品久久一区免费式| 国产精品无码久久av不卡| 亚洲国产色播av在线| 深夜福利在线观看视频| 亚洲精品无码mⅴ在线观看| 99精品久久久久中文字幕| 老熟妇性老熟妇性色| 三男一女吃奶添下面视频| 在线播放免费人成毛片试看| 国产成人8x人网站在线视频| 欧美疯狂做受xxxx高潮| 亚洲不卡av不卡一区二区| 一区二区狠狠色丁香久久婷婷| 夜夜高潮夜夜爽夜夜爱爱一区| √天堂资源地址中文在线| 香蕉久久av一区二区三区app| 人妻三级日本香港三级极97| 亚洲一卡二卡三卡四卡| 人妻熟女 视频二区 视频一区| 久久只有这里有精品4| 国产大片黄在线观看| 亚欧无线一线二线三线区别| 内射视频←www夜| 影音先锋中文字幕人妻| 久久精品国产精品青草|