在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

COX5A Antibody

  • 中文名稱:
    COX5A兔多克隆抗體
  • 貨號:
    CSB-PA070299
  • 規格:
    ¥1090
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    COX antibody; COX VA antibody; COX5A antibody; COX5A_HUMAN antibody; Cytochrome c oxidase polypeptide Va antibody; Cytochrome c oxidase polypeptide; mitochondrial antibody; Cytochrome c oxidase subunit 5A antibody; Cytochrome c oxidase subunit 5A; mitochondrial antibody; Cytochrome c oxidase subunit Va antibody; mitochondrial antibody; Mitochondrial cytochrome c oxidase subunit Va antibody; VA antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human COX5a.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.
  • 基因功能參考文獻:
    1. The monomeric COX1 assembly intermediate accumulates demonstrating a function of COX5A in complex IV biogenesis. A potential therapeutic lead is demonstrated by showing that copper supplementation leads to partial rescue of complex IV deficiency in patient fibroblasts. PMID: 28247525
    2. Our current study showed that COX Va may play a role in migration and invasion of NSCLC cells and can be used as a biomarker to predict aggressiveness of NSCLC. PMID: 22748147
    3. Novel insights into the assembly and function of human nuclear-encoded cytochrome c oxidase subunits 5a PMID: 20307258
    4. Data show that Bcl-2 expression positively influences the targeting of nuclear-encoded COX Va and Vb to the mitochondria of cancer cells. PMID: 19834492
    5. study points to a role for surfeit 1(SURF1) in promoting the association of cytochrome c oxidase II with the cytochrome c oxidase I.cytochrome c oxidase subunit 4.cytochrome c oxidase subunit 5A subassembly PMID: 14607829

    顯示更多

    收起更多

  • 相關疾病:
    Mitochondrial complex IV deficiency is a rare condition caused by mutation in COX5A that lead to pulmonary arterial hypertension (PAH), failure to thrive and lactic acidemia.
  • 亞細胞定位:
    Mitochondrion inner membrane; Peripheral membrane protein; Matrix side.
  • 蛋白家族:
    Cytochrome c oxidase subunit 5A family
  • 數據庫鏈接:

    HGNC: 2267

    OMIM: 603773

    KEGG: hsa:9377

    STRING: 9606.ENSP00000317780

    UniGene: Hs.401903



主站蜘蛛池模板: 国内揄拍国内精品对白86| 国产成人无码午夜视频在线播放| 久久精品aⅴ无码中文字字幕不卡| 成人无码精品免费视频在线观看| 秋霞av鲁丝片一区二区| 亚洲 欧美日韩 综合 国产| 又粗又硬整进去好爽视频| 亚洲精品无码不卡在线播放he| 少妇被又大又粗又爽毛片| 少妇裸体性生交| 人妻丰满熟妞av无码区| 久久精品国产99久久香蕉| 午夜爽爽爽男女免费观看麻豆国产 | 国产三级农村妇女在线| 人妻丰满熟妇ⅴ无码区a片| 午夜男女爽爽影院免费视频下载 | 久久综合丝袜日本网| 日本欧美一区二区三区在线播放| 久久99er精品国产首页| 丰满人妻在公车被猛烈进入电影| 免费无码va一区二区三区| 国产成人综合在线女婷五月99播放| 色综合亚洲一区二区小说性色aⅴ| 国产农村妇女毛片精品久久| 香蕉av福利精品导航| 国产亚洲一卡2卡3卡4卡网站| 在线播放偷拍一区精品| 国内女人喷潮完整视频| 国内少妇偷人精品免费| 亚洲国产超清无码专区| 国产精品免费久久久久影院仙踪林 | 中文字幕在线精品视频| 久久欧美与黑人双交男男| 亚洲精品尤物av在线观看不卡 | 久久婷婷五月综合色首页| 一本aⅴ高清一区二区三区| 日韩亚洲欧美中文高清在线| 色偷偷88888欧美精品久久久| 久久国产热精品波多野结衣av| 中国老妇xxxx性开放| 无码成人一区二区三区|