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  4. COX18 Antibody

COX18 Antibody

  • 中文名稱：
    COX18兔多克隆抗體
  • 貨號：
    CSB-PA203427
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using CSB-PA203427(COX18 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA203427(COX18 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    COX18
  • 別名：
    COX18 antibody; COX18 cytochrome c oxidase assembly homolog (S. cerevisiae) antibody; COX18_HUMAN antibody; COX18Hs antibody; Cox18Hs1 protein antibody; Cox18Hs2 protein antibody; Cox18Hs3 protein antibody; Cytochrome c oxidase assembly homolog (S. cerevisiae) antibody; Cytochrome c oxidase assembly protein 18 antibody; FLJ38991 antibody; MGC126733 antibody; Mitochondrial COX18 antibody; Mitochondrial inner membrane protein COX18 antibody; OXA1L2 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthetic peptide of Human COX18
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Mitochondrial membrane insertase required for the translocation of the C-terminus of cytochrome c oxidase subunit II (MT-CO2/COX2) across the mitochondrial inner membrane. Plays a role in MT-CO2/COX2 maturation following the COX20-mediated stabilization of newly synthesized MT-CO2/COX2 protein and before the action of the metallochaperones SCO1/2. Essential for the assembly and stability of the mitochondrial respiratory chain complex IV (also known as cytochrome c oxidase).
  • 基因功能參考文獻：
    1. COX20 stabilizes COX2 during insertion of its N-proximal transmembrane domain, and subsequently, COX18 transiently interacts with COX2 to promote translocation across the inner membrane of the COX2 C-tail that contains the apo-CuA site. The release of COX18 from this complex coincides with the binding of the SCO1-SCO2-COA6 copper metallation module to COX2-COX20 to finalize COX2 biogenesis. PMID: 28330871
    2. Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator) PMID: 20819778
    3. Observational study of gene-disease association. (HuGE Navigator) PMID: 20877624
    4. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator) PMID: 20379614
    5. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20200953
    6. COX18 mutations may be very rare or associated with other phenotypes than isolated COX deficiency in infancy. PMID: 19373256
    7. Both hCox18p and hCox19p present significant amino acid identity with the corresponding yeast polypeptides and reveal highly conserved functional domains. PMID: 16212937

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  • 亞細胞定位：
    Mitochondrion inner membrane; Multi-pass membrane protein.
  • 蛋白家族：
    OXA1/ALB3/YidC family
  • 數據庫鏈接：

    HGNC: 26801

    OMIM: 610428

    KEGG: hsa:285521

    STRING: 9606.ENSP00000295890

    UniGene: Hs.356697



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