在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

COX17 Antibody

  • 中文名稱:
    COX17兔多克隆抗體
  • 貨號:
    CSB-PA005829GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    COX 17 antibody; COX17 antibody; COX17 cytochrome c oxidase assembly homolog (S. cerevisiae) antibody; COX17 cytochrome c oxidase assembly homolog antibody; COX17 homolog cytochrome c oxidase assembly protein antibody; COX17_HUMAN antibody; cytochrome c oxidase assembly protein cox17 homolog antibody; Cytochrome c oxidase copper chaperone antibody; Human homolog of yeast mitochondrial copper recruitment antibody; MGC104397 antibody; MGC117386 antibody; OTTHUMP00000215284 antibody; OTTHUMP00000215285 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human COX17
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Copper metallochaperone essential for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. Binds two copper ions and delivers them to the metallochaperone SCO1 which transports the copper ions to the Cu(A) site on the cytochrome c oxidase subunit II (MT-CO2/COX2).
  • 基因功能參考文獻:
    1. These results collectively indicate that Cox17 might not participate in the action of these anticancer organoruthenium complexes, and further verify the distinct anticancer mechanism of the organoruthenium(II) complexes from cisplatin. PMID: 27235272
    2. Data show that the redox state of cytochrome c oxidase assembly protein 17 (Cox17), mitochondrial membrane transport protein Mia40 and superoxide dismutase 1 (SOD1) in the cytoplasm were directly observed with in-cell NMR spectroscopy. PMID: 26589182
    3. Data suggest that Cox17 enhances the reactivity of some platinum/organoplatinum antineoplastic drugs but suppresses the reactivity of at least one platinum antineoplastic drug; glutathione modulates binding of platinum/organoplatinum drugs to Cox17. PMID: 26399480
    4. Functional role of two interhelical disulfide bonds in human Cox17 protein from a structural perspective. PMID: 21816817
    5. Data imply that up-regulation of COX17 function and increased cytochrome c oxidase activity are frequent features of lung carcinogenesis. PMID: 14612491
    6. The binding of copper to Cox17 is needed to activate cytochrome c oxidase by Cox17. PMID: 15504366
    7. Cox17-mediated copper metallation of Sco1, as well as the subsequent failure of Cu(A) site maturation, is the basis for the inefficient assembly of the cytochrome c oxidase complex in SCO1 patients PMID: 16520371
    8. Cox17 was studied with regard to its expression, purification, and formation of mixed disulfide adducts with sulfhydryl reagents. PMID: 17208454
    9. XAS (X-ray absorption spectroscopy) determined that Cu4Cox17 contains a Cu4S6-type copper-thiolate cluster, which may provide safe storage of an excess of copper ions PMID: 17672825
    10. Cu(I)HCox17(2S-S), i.e., the copper-loaded form of the protein, can transfer simultaneously copper(I) and two electrons to the human cochaperone Sco1 (HSco1) in the oxidized state, i.e., with its metal-binding cysteines forming a disulfide bond. PMID: 18458339
    11. the absence of Cox17 interferes with copper delivery to Cox2, but not to Cox1. PMID: 19393246

    顯示更多

    收起更多

  • 亞細胞定位:
    Mitochondrion intermembrane space. Cytoplasm.
  • 蛋白家族:
    COX17 family
  • 組織特異性:
    Ubiquitous.
  • 數據庫鏈接:

    HGNC: 2264

    OMIM: 604813

    KEGG: hsa:10063

    STRING: 9606.ENSP00000261070

    UniGene: Hs.534383



主站蜘蛛池模板: 欧亚乱熟女一区二区在线 | 午夜无码人妻av大片色欲| 国产精品伦一区二区三级视频| 成人视频在线观看| 8ⅹ8x擦拨擦拨成人免费视频| 久久亚洲欧美国产精品| 亚洲色无码中文字幕yy51999| 日本免费一区二区三区最新| 国产成人啪精品视频免费网站软件| 无码精品a∨在线观看十八禁| 亚洲精品午夜国产va久久成人| 亚洲已满18点击进入在线看片| 84pao国产成视频永久免费| 亚洲成a∧人片在线播放无码| 国产xxxx视频在线观看| 99精品视频在线观看| 无码免费一区二区三区免费播放 | 一本色综合网久久| 无码国产成人午夜电影观看| 欧美日韩中文在线字幕视频| 黑人粗硬进入过程视频| 久在线精品视频线观看| 一本大道无码av天堂| 4444亚洲人成无码网在线观看| 国产精品嫩草影院av| 国产白丝精品爽爽久久蜜臀 | 成人无码在线视频网站| 丰满少妇在线观看网站| 九九久久精品国产av片国产| 琪琪电影午夜理论片八戒八戒| 日本亚洲欧美日韩国产ay | 日日噜噜夜夜狠狠久久蜜桃| 天天躁日日躁狠狠躁性色av| 草的我好爽视频| 少妇把腿扒开让我爽爽视频| 十八禁啪啪无遮挡网站| 蜜桃av麻豆av果冻传媒| 18禁免费观看网站| 蜜臀av网站在线| 怡红院一区二区三区在线| 久久成人影院精品777|