在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CORO1C Antibody

CORO1C Antibody

  • 中文名稱：
    CORO1C兔多克隆抗體
  • 貨號：
    CSB-PA581290
  • 規格：
    ￥1100
  • 圖片：
    • The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA581290(CORO1C Antibody) at dilution 1/60. (Original magnification: ×200)
    • The image is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA581290(CORO1C Antibody) at dilution 1/60. (Original magnification: ×200)
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Lovo cells, Primary antibody: CSB-PA581290(CORO1C Antibody) at dilution 1/670, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    CORO1C
  • 別名：
    COR1C_HUMAN antibody; CORO 1C antibody; Coro1c antibody; Coronin 1c antibody; Coronin actin binding protein 1C antibody; Coronin-1C antibody; Coronin-3 antibody; Coronin1c antibody; Coronin3 antibody; CRNN 4 antibody; CRNN4 antibody; HCRNN 4 antibody; hCRNN4 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human CORO1C
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
    IHC 1:100-1:300
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1. Increases the presence of activated RAC1 at the leading edge of migrating cells. Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments. Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission. Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. Required for normal cell proliferation, cell migration, and normal formation of lamellipodia. Required for normal distribution of mitochondria within cells.; Involved in myogenic differentiation.
  • 基因功能參考文獻：
    1. Coronin 1c protein and F-actin protein are highly expressed in breast cancer and their expression may be related to the metastasis of breast cancer cells. PMID: 30150608
    2. circBIRC6 and circCORO1C are functionally associated with the pluripotent state in undifferentiated human embryonic stem cells PMID: 29074849
    3. It would appear that YB-1 could regulate cell invasion and migration via downregulation of its indirect target coronin-1C. The association between YB-1 and coronin-1C offers a novel approach by which metastasis of breast cancer cells could be targeted and abrogated. PMID: 28302118
    4. findings emphasize the power of genetic modifiers, PLS3 and CORO1C, to unravel the cellular pathomechanisms underlying spinal muscular atrophy (SMA)--and the power of combinatorial therapy based on splice correction of SMN2 and endocytosis improvement to efficiently treat SMA PMID: 27499521
    5. Data indicate that coronin 1C protein (CORO1C) was a direct target of the microRNA miR-1/133a cluster in EBC-1 CORO1C was a direct target of the miR-1/133a cluster in lung-squamous cell carcinoma cell line EBC-1. PMID: 25518741
    6. Coro1C mediated Rac1 trafficking through actin-rich vesicles. PMID: 25862165
    7. Coronin-1C overexpression is associated withand hepatocellular carcinoma growth through enhancement of tumor cell proliferation and migration, which are correlated with Rac-1 activation. PMID: 23292607
    8. Coronin 3 promotes gastric cancer metastasis via the up-regulation of MMP-9 and cathepsin K. PMID: 22974233
    9. Patients with higher coronin-1C expression had a more advanced stage of hepatocellular carcinoma. PMID: 20678442
    10. There is a strong expression of both SELPLG and coronin-1C in the majority of primary effusion lymphomas, irrespective of their gene dosage. SELPLG is critical for cell migration and chemotaxis, while CORO1C regulates actin-dependent processes. PMID: 20690162
    11. Coronin 1C negatively regulates epithelial cell migration via FAK-mediated inhibition of cell-matrix adhesion. PMID: 19913511
    12. oligomerization, F-actin interaction and membrane association are mediated by carboxyl terminus PMID: 12377779
    13. Fndings postulate a role for CRN2 isoforms in the structural and functional organization of F-actin in highly ordered protein complexes. PMID: 19651142

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium. Cell projection, ruffle membrane. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Endosome membrane.; [Isoform 3]: Cell membrane, sarcolemma. Cytoplasm, myofibril, sarcomere. Cell junction, synapse. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Cytoplasm, cytoskeleton. Cytoplasm, cell cortex.
  • 蛋白家族：
    WD repeat coronin family
  • 組織特異性：
    Ubiquitous.
  • 數據庫鏈接：

    HGNC: 2254

    OMIM: 605269

    KEGG: hsa:23603

    STRING: 9606.ENSP00000261401

    UniGene: Hs.330384



主站蜘蛛池模板： 国产高清狼人香蕉在线| 亚洲国产美女精品久久久久| 午夜福利电影| 熟睡人妻被讨厌的公侵犯| 人妻系列无码专区久久五月天| 人人人爽人人爽人人av| 亚洲深深色噜噜狠狠网站| 久久精品99国产精品日本| 国产免费看插插插视频| 欧美z0zo人禽交欧美人禽交 | 成 人 综合 亚洲另类| 国产美熟女乱又伦av果冻传媒| 久久丫精品系列| 强睡邻居人妻中文字幕| 一本久道久久综合狠狠爱| 中国精品无码免费专区午夜| 制服丝袜亚洲欧美中文字幕| 思思久久99热只有频精品66| 日本成aⅴ人片日本伦| 国产精品进线69影院| 亚洲性人人天天夜夜摸18禁止| 99久久精品国产波多野结衣| 乱人伦中文字幕成人网站在线| 山东熟女啪啪哦哦叫| 国产精品视频一区二区亚瑟| 99热成人精品热久久| 一本一道波多野结衣av中文| 久久婷婷五月综合色欧美| 亚洲精品成人网站在线播放| 丰满的少妇hd高清中文字幕| 亚洲爱婷婷色婷婷五月| 狠狠色狠狠色综合久久| 精品国产福利在线视频| 真正免费毛片在线播放| 久久99国产精品久久99果冻传媒| 成人无码a片一区二区三区免| 黑人巨大av在线播放无码| 久久久久久久久久久久| 亚洲无线看天堂av| 亚洲欧美中文高清在线专区| 性开放的女人aaa片|