在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CORO1A Antibody

  • 中文名稱:
    CORO1A兔多克隆抗體
  • 貨號:
    CSB-PA005813GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CORO1A
  • 別名:
    Actin binding protein antibody; CLABP antibody; Clipin A antibody; Clipin-A antibody; CLIPINA antibody; COR1A_HUMAN antibody; CORO1A antibody; Coronin 1 antibody; Coronin actin binding protein 1A antibody; Coronin like protein A antibody; Coronin like protein p57 antibody; Coronin-1A antibody; Coronin-like protein A antibody; Coronin-like protein p57 antibody; FLJ41407 antibody; HCORO1 antibody; MGC117380 antibody; OTTHUMP00000163017 antibody; p57 antibody; TACO antibody; Tryptophan aspartate containing coat protein antibody; Tryptophan aspartate-containing coat protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human CORO1A
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.
  • 基因功能參考文獻:
    1. Levels of p21 and p27 were decreased in TACO or pAKT overexpressing HCC due to SKP2 upregulation. PMID: 27779207
    2. Data suggest that CORO1A plays key role in neuronal signaling; roles of CORO1A in multiple signaling pathways suggest that CORO1A may influence cross talk between key pathways. [REVIEW] PMID: 28215292
    3. It has been shown that WDR26 promotes Rac1 membrane translocation following a Coro1A-like and Coro1A-dependent mechanism. PMID: 27835684
    4. Our studies demonstrate the importance of intact CORO1A C-terminal domains in thymic egress and T-cell survival, as well as in defense against viral pathogens. PMID: 26476480
    5. These findings suggest that coronin 1A modulates endothelial cell apoptosis by regulating p38beta expression and activation. PMID: 25936522
    6. Together, these findings both in Jurkat T cells as well as in primary T cells indicate a regulatory role of Coro1A on PKCtheta; recruitment and function downstream of the TCR leading to NF-kappaB transactivation. PMID: 25889880
    7. mutatiions result in abnormal T-cells, severe combined immunodeficiency of an epidermodysplasia verruciformis-human papilloma virus mucocutaneous syndrome with B and NK defects and shortened telomeres PMID: 25073507
    8. Coronin 1 trimerization is essential to promote mycobacterial survival within macrophages PMID: 25217836
    9. Nox4-mediated redox regulation of PTP1B serves as a modulator, in part through coronin-1C, of the growth and migration of glioblastoma cells. PMID: 24239742
    10. Absence of coronin 1A is associated with severe combined immunodeficiency in humans, hypomorphic mutations lead to a profound defect in naive T cells, expansion of oligoclonal memory T cells, and susceptibility to Epstein Barr B lymphoproliferation. PMID: 25269405
    11. Results indicate that Coronin1 proteins are at the center of a regulatory hub that coordinates Rac1 activation, effector exchange, and the F-actin organization state during cell signaling. PMID: 24980436
    12. show a critical role for F-actin deconstruction in cytotoxic function and immunological secretion and identify Coro1A as its mediator PMID: 24760828
    13. These results demonstrate that coronin-1a is a novel antibody target for clinically isolated syndrome and multiple sclerosis. PMID: 23745754
    14. Our findings define a new clinical entity of a primary immunodeficiency with increased susceptibility to EBV-induced lymphoproliferation in patients associated with hypomorphic Coronin-1A mutation. PMID: 23522482
    15. PU.1 and CEBPA are direct transcriptional regulators of CORO1A in acute promyelocytic leukemia and acute myeloid leukemia. PMID: 23252456
    16. Constitutive turnover of phosphorylation at Thr-412 of p57/coronin-1 regulates its interaction with actin. PMID: 23100250
    17. Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation PMID: 21873980
    18. Instead of regulating the F-actin cytoskeleton, coronin 1 functions in balancing pro- and antiapoptotic signals by regulating divalent calcium ion fluxes and calcineurin activation downstream of the T cell receptor. PMID: 21339362
    19. These results demonstrate that p57/coronin-1 forms homodimers, that the association is mediated by the leucine zipper structure in the C-terminal region, and that it plays a role in the cross-linking of F-actin in the cell. PMID: 15601263
    20. The leukocyte plasma membrane associates with the actin cytoskeleton through coronin-1. PMID: 15800061
    21. downregulation of TACO gene transcription restricts entry/survival of mycobacteria within macrophages PMID: 16040207
    22. Our results strongly suggested that there was a new actin-binding region at the C-terminus of p57. PMID: 16467882
    23. Coronin-1 accumulates at the leading edge of migrating neutrophils and at the nascent phagosome. PMID: 17442961
    24. phosphorylation of p57/coronin-1 down-regulates its association with actin and modulates the reorganization of actin-containing cytoskeleton PMID: 18693254
    25. Findings establish a function for coronin 1A in T cell egress, identify a surface of coronin involved in Arp2/3 regulation. PMID: 18836449
    26. Circulating neutrophils from CF patients had more coronin-1 expression, associated with a lower apoptosis rate PMID: 19454722

    顯示更多

    收起更多

  • 相關疾病:
    Immunodeficiency 8 (IMD8)
  • 亞細胞定位:
    Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle, phagosome membrane.
  • 蛋白家族:
    WD repeat coronin family
  • 組織特異性:
    Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut.
  • 數據庫鏈接:

    HGNC: 2252

    OMIM: 605000

    KEGG: hsa:11151

    STRING: 9606.ENSP00000219150

    UniGene: Hs.415067



主站蜘蛛池模板: 三级网站视频在在线播放| 国产成人精品一区二区三区免费看| 久久人人爽人人爽爽久久小说| 好了av第四综合无码久久| 国产露脸无套对白在线播放| 香蕉免费一区二区三区在| 亚洲精品拍拍央视网出文| 国产亚洲精品资源在线26u| 亚洲 小说区 图片区 都市| 国产成人无码国产亚洲| 免费va人成视频网站全| 一本一本久久a久久精品综合麻豆| 国产免费久久精品99久久| 免费刺激性视频大片区| 丰满无码人妻熟妇无码区| 欧美日本免费一区二区三区| 97精品人妻一区二区三区香蕉| 国产免费啪嗒啪嗒视频看看| 性av无码天堂vr专区| 久久午夜羞羞影院免费观看| 午夜片神马影院福利| 国产重口老太和小伙乱| 99国精品午夜福利视频不卡 | 无码写真精品永久福利在线| 女上男下啪啪激烈高潮无遮盖| 日本猛少妇色xxxxx猛叫| 人人爽人人澡人人高潮| 亚洲中文字幕av每天更新 | 欧美日韩一区二区综合| 欧洲-级毛片内射| 国产欧美日韩亚洲精品专区| 农村老熟妇乱子伦视频| 无码gogo大胆啪啪艺术| 美女裸奶100%无遮挡免费网站| 四虎成人精品一区二区免费网站| 精品国产一区二区三区四区阿崩| 国产精品国产三级国av麻豆| 亚洲综合欧美在线一区在线播放 | 无码中文人妻在线一区| 国产高清在线精品二区| 欧妇女乱妇女乱视频|