在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CORO1A Antibody

  • 中文名稱:
    CORO1A兔多克隆抗體
  • 貨號:
    CSB-PA005813GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CORO1A
  • 別名:
    Actin binding protein antibody; CLABP antibody; Clipin A antibody; Clipin-A antibody; CLIPINA antibody; COR1A_HUMAN antibody; CORO1A antibody; Coronin 1 antibody; Coronin actin binding protein 1A antibody; Coronin like protein A antibody; Coronin like protein p57 antibody; Coronin-1A antibody; Coronin-like protein A antibody; Coronin-like protein p57 antibody; FLJ41407 antibody; HCORO1 antibody; MGC117380 antibody; OTTHUMP00000163017 antibody; p57 antibody; TACO antibody; Tryptophan aspartate containing coat protein antibody; Tryptophan aspartate-containing coat protein antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human CORO1A
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    May be a crucial component of the cytoskeleton of highly motile cells, functioning both in the invagination of large pieces of plasma membrane, as well as in forming protrusions of the plasma membrane involved in cell locomotion. In mycobacteria-infected cells, its retention on the phagosomal membrane prevents fusion between phagosomes and lysosomes.
  • 基因功能參考文獻:
    1. Levels of p21 and p27 were decreased in TACO or pAKT overexpressing HCC due to SKP2 upregulation. PMID: 27779207
    2. Data suggest that CORO1A plays key role in neuronal signaling; roles of CORO1A in multiple signaling pathways suggest that CORO1A may influence cross talk between key pathways. [REVIEW] PMID: 28215292
    3. It has been shown that WDR26 promotes Rac1 membrane translocation following a Coro1A-like and Coro1A-dependent mechanism. PMID: 27835684
    4. Our studies demonstrate the importance of intact CORO1A C-terminal domains in thymic egress and T-cell survival, as well as in defense against viral pathogens. PMID: 26476480
    5. These findings suggest that coronin 1A modulates endothelial cell apoptosis by regulating p38beta expression and activation. PMID: 25936522
    6. Together, these findings both in Jurkat T cells as well as in primary T cells indicate a regulatory role of Coro1A on PKCtheta; recruitment and function downstream of the TCR leading to NF-kappaB transactivation. PMID: 25889880
    7. mutatiions result in abnormal T-cells, severe combined immunodeficiency of an epidermodysplasia verruciformis-human papilloma virus mucocutaneous syndrome with B and NK defects and shortened telomeres PMID: 25073507
    8. Coronin 1 trimerization is essential to promote mycobacterial survival within macrophages PMID: 25217836
    9. Nox4-mediated redox regulation of PTP1B serves as a modulator, in part through coronin-1C, of the growth and migration of glioblastoma cells. PMID: 24239742
    10. Absence of coronin 1A is associated with severe combined immunodeficiency in humans, hypomorphic mutations lead to a profound defect in naive T cells, expansion of oligoclonal memory T cells, and susceptibility to Epstein Barr B lymphoproliferation. PMID: 25269405
    11. Results indicate that Coronin1 proteins are at the center of a regulatory hub that coordinates Rac1 activation, effector exchange, and the F-actin organization state during cell signaling. PMID: 24980436
    12. show a critical role for F-actin deconstruction in cytotoxic function and immunological secretion and identify Coro1A as its mediator PMID: 24760828
    13. These results demonstrate that coronin-1a is a novel antibody target for clinically isolated syndrome and multiple sclerosis. PMID: 23745754
    14. Our findings define a new clinical entity of a primary immunodeficiency with increased susceptibility to EBV-induced lymphoproliferation in patients associated with hypomorphic Coronin-1A mutation. PMID: 23522482
    15. PU.1 and CEBPA are direct transcriptional regulators of CORO1A in acute promyelocytic leukemia and acute myeloid leukemia. PMID: 23252456
    16. Constitutive turnover of phosphorylation at Thr-412 of p57/coronin-1 regulates its interaction with actin. PMID: 23100250
    17. Coronin 1A promotes a cytoskeletal-based feedback loop that facilitates Rac1 translocation and activation PMID: 21873980
    18. Instead of regulating the F-actin cytoskeleton, coronin 1 functions in balancing pro- and antiapoptotic signals by regulating divalent calcium ion fluxes and calcineurin activation downstream of the T cell receptor. PMID: 21339362
    19. These results demonstrate that p57/coronin-1 forms homodimers, that the association is mediated by the leucine zipper structure in the C-terminal region, and that it plays a role in the cross-linking of F-actin in the cell. PMID: 15601263
    20. The leukocyte plasma membrane associates with the actin cytoskeleton through coronin-1. PMID: 15800061
    21. downregulation of TACO gene transcription restricts entry/survival of mycobacteria within macrophages PMID: 16040207
    22. Our results strongly suggested that there was a new actin-binding region at the C-terminus of p57. PMID: 16467882
    23. Coronin-1 accumulates at the leading edge of migrating neutrophils and at the nascent phagosome. PMID: 17442961
    24. phosphorylation of p57/coronin-1 down-regulates its association with actin and modulates the reorganization of actin-containing cytoskeleton PMID: 18693254
    25. Findings establish a function for coronin 1A in T cell egress, identify a surface of coronin involved in Arp2/3 regulation. PMID: 18836449
    26. Circulating neutrophils from CF patients had more coronin-1 expression, associated with a lower apoptosis rate PMID: 19454722

    顯示更多

    收起更多

  • 相關疾病:
    Immunodeficiency 8 (IMD8)
  • 亞細胞定位:
    Cytoplasm, cytoskeleton. Cytoplasm, cell cortex. Cytoplasmic vesicle, phagosome membrane.
  • 蛋白家族:
    WD repeat coronin family
  • 組織特異性:
    Expressed in brain, thymus, spleen, bone marrow and lymph node. Low in lung and gut.
  • 數據庫鏈接:

    HGNC: 2252

    OMIM: 605000

    KEGG: hsa:11151

    STRING: 9606.ENSP00000219150

    UniGene: Hs.415067



主站蜘蛛池模板: 亚洲人成网站色7799| 国产一卡2卡3卡4卡精品| 精品亚洲国产成人av在线小说| 996热re视频精品视频这里| 伊人色综合久久天天| 9久9久女女热精品视频在线观看 | 亚洲色素色无码专区| 婷婷丁香五月中文字幕| 女人张开腿让男人桶爽| 免费网禁国产you女网站下载| 免费无码av片在线观看网址| 亚洲毛片多多影院| 伊人色综合一区二区三区| 高清粉嫩无套内谢国语播放| 又黄又湿啪啪响18禁| 国产精品亚洲色婷婷99久久精品| 少妇粉嫩小泬喷水视频| 久久本色成人综合网| 亚洲成av人片在线观看高清| 内射囯产旡码丰满少妇| 97人妻天天爽夜夜爽二区| 亚洲免费福利在线视频| 国产人成视频在线观看| 欧美成人精品手机在线| 国产美女a做受大片观看| 亚洲性无码av在线dvd| 爱做久久久久久| 青草青草久热国产精品| 人间精品视频在线播放| 亚洲一区二区三区影院 | 人人做人人爽国产视| 日本肉体裸xxxxbbbb| 国产一区二区三区小说| 日韩 欧美 国产 一区三| 免费国产午夜视频在线观看| 日日鲁鲁鲁夜夜爽爽狠狠视频97| 久久精品夜色噜噜亚洲a∨| 日韩精品一区二区大桥未久| 被灌满精子的波多野结衣| 熟妇人妻中文av无码| 97人妻免费碰视频碰免|