在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. COPS2 Antibody

COPS2 Antibody

  • 中文名稱：
    COPS2兔多克隆抗體
  • 貨號：
    CSB-PA231077
  • 規格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from COS-7 cells and COLO205 cells, using COPS2 antibody.
    • Immunofluorescence analysis of A549 cells, using COPS2 antibody.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) COPS2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    COPS2
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from internal of Human COPS2.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB,IF
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
    IF 1:100-1:500
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Involved in early stage of neuronal differentiation via its interaction with NIF3L1.
  • 基因功能參考文獻：
    1. Data indicate that DET1- and DDB1-associated protein 1 (DDA1)-mediated tumor progression is associated with the activation of the NF-kappa B (NFkappaB)/COP9 signalosome 2(CSN2)/glycogen synthase kinase3beta (GSK3beta) pathway. PMID: 26942699
    2. AIBP promotes apoA-1 binding to ABCA1 on the cell membrane of macrophages and prevents ABCA1 protein from CSN2-mediated degradation so as to prevent foam cell formation PMID: 27017521
    3. CSN2 knockdown cells underwent non-apoptotic cell death. PMID: 19400951
    4. demonstrate Alien-MLK2 interaction and also show that MLK2 is able to phosphorylate Alien; Alien, DAX-1 and thyroid hormone receptor mediated transcriptional silencing is strongly enhanced in the presence of active MLK2 PMID: 15062575
    5. Alien and Sin3A reside together in vivo with the vitamin D3 receptor on the human 24-hydroxylase (CYP24) promoter containing vitamin D3 response elements by chromatin immunoprecipitation PMID: 15173382
    6. Data show that Alien binds in vivo and in vitro to NAP1 and modulates its activity by enhancing NAP1-mediated nucleosome assembly on DNA. PMID: 17339334
    7. Protein interactions of Alien involving nucleophosmin, ERCC3, TRIP11, as well as CRSP3. PMID: 17438371
    8. Alien inhibits E2F1 gene expression and cell proliferation. PMID: 17570542
    9. the interaction between Alien and the tumor suppressors p33ING1 and p33ING2 reveals a novel cellular protein network PMID: 17929852
    10. CSN2 gene was identified in the genome-wide loss-of-function genetic screen as putative tumor suppressor located at 15q21.2. PMID: 17968325
    11. Alien seems to modulate nucleosome assembly activity. This suggests that Alien is acting on chromatin not only through recruitment of histone-modifying activities, but also through enhancing nucleosome assembly. PMID: 18174916
    12. A subunit of the COP9 signalosome interacted physically with the anaphase-promoting complex and showed a genetic instability of cells. PMID: 19535905

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CSN2 family
  • 數據庫鏈接：

    HGNC: 30747

    OMIM: 604508

    KEGG: hsa:9318

    STRING: 9606.ENSP00000299259

    UniGene: Hs.369614



主站蜘蛛池模板： 午夜免费视频| 欧美性猛交xxxx黑人猛交| 无遮挡裸体免费视频尤物| 中文字幕人妻高清乱码| 狠狠色综合久久丁香婷婷| 韩国精品久久久久久无码| 特大黑人娇小亚洲女| 国产对白老熟女正在播放| 欧美极品video粗暴| 国精产品69永久中国有限| 国产欧美va天堂在线观看视频下载 | 欧美肥婆性猛交xxxx| 国产亚洲精aa在线观看| 国产精品未满十八禁止观看| 久久国产精品一国产精品| 日本午夜看x费免| 亚洲国产香蕉碰碰人人| 国产激情久久久久久熟女老人| 国产人妻久久精品二区三区特黄| 少妇扒开双腿让我看个够| 国产又爽又大又黄a片| 韩国美女视频黄是免费| 亚洲香蕉aⅴ视频在线播放| 婷婷伊人久久大香线蕉av| 亚洲精品日本久久一区二区三区 | 99精品国产在热久久无毒| 中文无码日韩欧| 久久久久噜噜噜亚洲熟女综合| 波多野结衣爽到高潮大喷| 中日韩产精品1卡二卡三卡| 亚洲精品自在在线观看| 国产精品久久久久秋霞鲁丝 | 在线日韩av免费永久观看| 一区二区三区无码被窝影院| 亚洲色无码专线精品观看| 午夜dy888国产精品影院| 亚洲a∨无码无在线观看| 色喜国模李晴超大尺度 | 中文字幕无码家庭乱欲| 亚洲精品亚洲人成人网| 免费看无码自慰一区二区|