在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

COL6A3 Antibody

  • 中文名稱:
    COL6A3兔多克隆抗體
  • 貨號:
    CSB-PA053506
  • 規(guī)格:
    ¥2024
  • 圖片:
    • Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue using Collagen VI α3 antibody.
    • Immunofluorescence analysis of HeLa cells, using Collagen VI α3 antibody.
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) COL6A3 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from internal of Human Collagen VI α3.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Collagen VI acts as a cell-binding protein.
  • 基因功能參考文獻:
    1. COL6A3 could influence the viability and angiogenesis of bladder cancer cells. COL6A3 may have a certain relationship with the TGF-beta/Smad-induced EMT process. PMID: 30066698
    2. The morphology and immunophenotype of all 6 cases was analogous to those with the canonical COL1A1-PDGFB fusion; none of the cases showed fibrosarcomatous transformation. This study illustrates that the COL6A3-PDGFD fusion product is rare in dermatofibrosarcoma protuberans, and associated with an apparent predilection for breast PMID: 30014607
    3. Study found COL6A3 expression to be downregulated and associated with poor prognosis in human colorectal cancer (CRC). In silico analysis of cell typespecific gene expression and COL6A3 knockout experiments indicated the clinical relevance of COL6A3 in the development of CRC. PMID: 29620224
    4. COL6A mutation Congenital Muscular Dystrophy showed the muscle weakness and poor respiratory function. PMID: 29465610
    5. two compound heterozygous mutations in COL6A3 gene lead to myopathy from Ullrich congenital muscular dystrophy and Bethlem myopathy spectrum. PMID: 29894794
    6. COL6A3-associated dystonia represents a newly identified autosomal-recessive entity characterized clinically by an early symptom onset with variable distribution. PMID: 26687111
    7. Overexpression of endotrophin led to a fibrotic program in white adipose tissue (WAT) adipocytes, a proinflammatory program in (WAT) macrophages, and upregulation of both profibrotic and proinflammatory genes in the stromal vascular fraction isolated from WAT. PMID: 27729337
    8. Patients with chronic kidney disease (CKD) are at increased risk of end-stage renal disease (ESRD) and early mortality. Serum endotrophin, a COL6A3 cleavage product was significantly associated with progression to ESRD. PMID: 28403201
    9. In conjunction with the relatively high frequency of homozygous carriers of reported mutations in publically available databases, our data call a causal role for variants in COL6A3 in isolated dystonia into question. PMID: 26872670
    10. Data indicate that circulating plasma COL6A3 in colorectal cancer (CRC) patients was upregulated significantly comparing with healthy peoples. PMID: 26338966
    11. COL6A mutations were identified in eight cases having clinical phenotypes of Ullrich congenital muscular dystrophy (UCMD) or Bethlem myopathy (BM). PMID: 25635128
    12. Recessive mutations in the alpha3 (VI) collagen gene COL6A3 cause early-onset isolated dystonia. PMID: 26004199
    13. Increased adipocyte COL6A3 expression associates with insulin resistance; COL6A3 mRNA associates with small adipocyte size PMID: 24719315
    14. The heterozygous c.3353A>C mutation in exon 8 of the COL6A3 gene is associated with the Bethlem myopathy with autosomal dominant inheritance. PMID: 25449070
    15. This study showed that COL6A3 expression appeared to be lowered in obesity, whereas diet- and surgery-induced weight loss increased COL6A3 expression. PMID: 25337653
    16. In UCMD, 1 mutation was indentified in Chinese patients. PMID: 24801232
    17. Data indicate that endotrophin (COL6alpha3) levels are higher in diabetic patients. PMID: 24647224
    18. Postranslational processing of type VI collagen in articular cartilage was investigated: alpha3(VI) collagen C5 domain is initially incorporated into the newly formed type VI fibrils, but after secretion is cut and not in the mature pericellular matrix PMID: 11785962
    19. Mutations in COL6A3 cause severe and mild phenotypes of Ullrich congenital muscular dystrophy. PMID: 11992252
    20. The C-terminal Kunitz-type domain from the alpha3 chain of human type VI collagen (C5), a single amino-acid residue chain with three disulfide bridges, was refined at 0.9 A resolution in a monoclinic form PMID: 12077460
    21. These results suggest that different alpha3(VI) chain isoforms, containing also domains of the N10-N7 region, are required for assembling a proper collagen VI network in the extracellular matrix. PMID: 15965965
    22. the alpha3(VI) C5 domain is present in the extracellular matrix of SaOS-2 N6-C5 expressing cells and fibroblasts, which demonstrates that processing of the C-terminal region of the alpha3(VI) chain is not essential for microfibril formation PMID: 16613849
    23. Col6A3 fusion with colony-stimulating factor-1 gene is associated with tenosynovial giant cell tumors. PMID: 17918257
    24. in humans increased COL6A3 mRNA is associated with adipose tissue macrophage chemotaxis and inflammation and that weight gain PMID: 19837927

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Bethlem myopathy 1 (BTHLM1); Ullrich congenital muscular dystrophy 1 (UCMD1); Dystonia 27 (DYT27)
  • 亞細胞定位:
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族:
    Type VI collagen family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 2213

    OMIM: 120250

    KEGG: hsa:1293

    STRING: 9606.ENSP00000295550

    UniGene: Hs.233240



主站蜘蛛池模板: 国产免费啪嗒啪嗒视频看看 | 色噜噜狠狠狠综合曰曰曰| 中字幕一区二区三区乱码| 99久久久精品免费观看国产| 国产欠欠欠18一区二区| 麻豆国产97在线 | 欧美| 国内大量揄拍人妻精品視頻| 大学生被内谢粉嫩无套| 丰满少妇大叫太大太粗| 日产2021免费一区| 国产精品毛片在线完整版sab| 无码国产精品久久一区免费| 国产精品白浆一区二小说| 国产av精国产传媒| 亚洲国产午夜精华无码福利| 久久精品高清一区二区三区| 夜夜揉揉日日人人| 伊人久久大香线蕉综合网站| 天堂一区人妻无码| 亚洲 日本 欧美 中文字幕| 午夜爽爽爽男女免费观看麻豆国产| 日本熟人妻中文字幕在线| 国产精品婷婷久久爽一下| 囯产精品久久久久久久久久妞妞| 国产女精品视频网站免费| 亚洲精品伊人久久久大香| 男人添女人囗交做爰视频| 国产精品永久免费视频| 99久久国产自偷自偷免费一区| 日日摸夜夜摸狠狠摸婷婷| 四库影院永久四虎精品国产| 最新高清无码专区| 人人妻人人做人人爽| 国产美女精品自在线拍免费| 亚洲跨种族黑人xxxxx| 国产成人无码a区精油按摩| 中字幕人妻一区二区三区| 末发育女av片一区二区| 亚洲成a人片在线观看中文无码| 精品一区二区三区无码免费直播 | 天堂在线中文网www|