在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

COL11A2 Antibody

  • 中文名稱:
    COL11A2兔多克隆抗體
  • 貨號(hào):
    CSB-PA001741
  • 規(guī)格:
    ¥1090
  • 圖片:
    • Western Blot analysis of HuvEc cells using COL11A2 Polyclonal Antibody
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    COL11A2
  • 別名:
    COBA2_HUMAN antibody; COL11A2 antibody; Collagen alpha 2(XI) antibody; Collagen alpha-2(XI) chain antibody; Collagen type XI alpha 2 antibody; Collagen XI a2 antibody; DAQB-79P13.8 antibody; DFNA13 antibody; DFNB53 antibody; FBCG2 antibody; HGNC:2187 antibody; HKE5 antibody; PARP antibody; Pro a2 chain of collagen type XI antibody; STL3 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the C-terminal region of Human COL11A2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:20000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    May play an important role in fibrillogenesis by controlling lateral growth of collagen II fibrils.
  • 基因功能參考文獻(xiàn):
    1. that the COL11A2 gene, which has previously been associated with familial osteoarthritis, may play a role in pain sensitization after the development of osteoarthritis PMID: 28741447
    2. Up to now, merely 7 loci have been linked to mid-frequency hearing loss. Only four genetic mid-frequency deafness genes, namely, DFNA10 (EYA4), DFNA8/12 (TECTA), DFNA13 (COL11A2), DFNA44 (CCDC50), have been reported to date. [review] PMID: 27142990
    3. Data indicate that Ala37Ser is the missense mutation located in the NC4 domain of the collagen type XI COL11A2 protein. PMID: 25633957
    4. A novel mutation in COL11A2 was found in a Japanese family with non-ocular Stickler syndrome. PMID: 25780254
    5. Hearing impairment in non-ocular Stickler syndrome is characterized by non-progressive hearing loss, present since childhood, and mostly mild to moderate in severity. Heterozygote mutations in COL11A2 were present in two pedigrees. PMID: 22796475
    6. These findings thus demonstrate that fibrochondrogenesis can result from either recessively or dominantly inherited mutations in COL11A2 PMID: 22246659
    7. The findings of a significant association between lip and/or palate clefts and two markers in the WNT3 and COL11A2 genes were the most consistent and were observed in all groups analysed and stratified. PMID: 22112025
    8. four loci showed the strongest associations with RA (P<0.005): ZNF391, OR2H1, C6orf26-RDBP and HLA-DPB1-COL11A2. PMID: 21293383
    9. A novel homozygous COL11A2 deletion causes a C-terminal protein truncation with incomplete mRNA decay in a Turkish patient. PMID: 21204229
    10. individuals carrying the C allele at the COL11A2 SNP site, rs2076311, had a lower risk of Kawasaki disease and had a lower probability of developing coronary artery lesions PMID: 20618517
    11. differential regulation by EWS/ERG sarcoma fusion protein and wild-type ERG PMID: 12554743
    12. Mutation in the COL11A2 gene was found in all affected individuals, which lends molecular support to the clinical notion that autosomal recessive Weissenbacher-Zweymuller syndrome (WZS) and otospondylomegaepiphyseal dysplasia (OSMED)are a single entity. PMID: 15558753
    13. mutation type and location are critical determinants in defining the phenotype of COL11A2 associated diseases PMID: 16033917
    14. COL11A2 transcription is regulated by Sp1 proteins and by binding to its proximal promoter PMID: 16734381
    15. diagnosis ofOtospondylomegaepiphyseal dysplasia was diagnosed by identifying a mutation in the COL11A2 gene that encodes the pre-pro-alpha2(XI) chain of type XI collagen that is involved in type II collagen fibrillogenesis. PMID: 18381781

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Otospondylomegaepiphyseal dysplasia, autosomal dominant (OSMEDA); Otospondylomegaepiphyseal dysplasia, autosomal recessive (OSMEDB); Deafness, autosomal dominant, 13 (DFNA13); Deafness, autosomal recessive, 53 (DFNB53); Fibrochondrogenesis 2 (FBCG2)
  • 亞細(xì)胞定位:
    Secreted, extracellular space, extracellular matrix.
  • 蛋白家族:
    Fibrillar collagen family
  • 數(shù)據(jù)庫鏈接:

    HGNC: 2187

    OMIM: 120290

    KEGG: hsa:1302

    UniGene: Hs.390171



主站蜘蛛池模板: 国产熟人av一二三区| 天天槽夜夜槽槽不停| 在线观看免费视频网站a站| 国产sm重味一区二区三区| 国产色婷婷五月精品综合在线| 国产成人亚洲综合网色欲网| 免费国产黄网站在线观看可以下载| 久久无码专区国产精品| 亚洲精品成人无码中文毛片不卡| 在线亚洲精品国产一区麻豆| a欧美爰片久久毛片a片| 国产人妻一区二区三区四区五区六| 亚洲熟妇av乱码在线观看| 国产亚洲综合网曝门系列| 高潮射精日本韩国在线播放| 国产精品v片在线观看不卡 | 欧美丰满一区二区免费视频 | 四虎影视国产精品久久| 久久婷婷狠狠综合激情| 久久精品水蜜桃av综合天堂| 国产艳妇av在线观看果冻传媒| 久久精品亚洲精品国产色婷| 国产爽视频在线观看视频| 国产农村老太xxxxhdxx| 88国产精品欧美一区二区三区| 精品国产乱码久久久久久下载| 农村乱人伦一区二区| 在线观看免费人成视频色9| 亚洲αv无码一区二区三区四区| 日韩午夜理论片 中文字幕| 亚洲人成中文字幕在线观看| 激情亚洲一区国产精品| 国产成人亚洲综合无码品善网| 特级毛片a片久久久久久| 中国凸偷窥xxxx自由视频妇科 | 国产片a国产片免费看视频| 男女啪啪进出阳道猛进| 亚洲va欧美va天堂v国产综合| 国内精品久久久久影视| 亚洲欧洲日产国无高清码图片| 成人性做爰aaa片免费|