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COG6 Antibody

  • 中文名稱:
    COG6兔多克隆抗體
  • 貨號:
    CSB-PA005710GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    COG6
  • 別名:
    CDG2L antibody; COD2 antibody; COG complex subunit 6 antibody; COG6 antibody; COG6_HUMAN antibody; Complexed with Dor1p 2 antibody; Component of oligomeric Golgi complex 6 antibody; Conserved oligomeric Golgi complex component 6 antibody; Conserved oligomeric Golgi complex protein 6 antibody; Conserved oligomeric Golgi complex subunit 6 antibody; KIAA1134 antibody; SHNS antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human COG6
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IF
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Required for normal Golgi function.
  • 基因功能參考文獻:
    1. COG6 is a novel shared risk locus for rheumatoid arthritis and systemic lupus erythematosus. PMID: 27193031
    2. study presents 7 additional patients with 4 novel COG6 mutations; genotype-phenotype correlation can be discerned ranging from deep intronic mutations found in Shaheen syndrome as the mildest form to loss-of-function mutations leading to early lethal congenital disorders of glycosylation phenotypes PMID: 26260076
    3. The aim of this study was to investigate whether the HCP5, TNIP1, TNFAIP3, SPATA2 and COG6 genes were genetic risk factors for psoriasis in Chinese population. PMID: 25264125
    4. Our findings implicate COG6 rs9548934C-->T genotypes and circulating miRNA-1 phenotype in modulating the occurrence and major adverse cardiovascular events of coronary artery disease. PMID: 25197382
    5. Targeted silencing of components of lobe B of the COG complex, namely COG5, COG6, COG7 and COG8, inhibited HIV-1 replication PMID: 25179963
    6. data implicate COG6 in the pathogenesis of a novel hypohidrotic disorder in humans that is distinct from congenital disorders of glycosylation. PMID: 23606727
    7. COG6 interaction with SNARE proteins via universal SNARE-binding motif of COG6 is important for Golgi complex intergrity. PMID: 23057818
    8. COG6 rs9548934C-->T polymorphism is associated with lower risk of premature coronary artery disease, especially in female subjects and subjects with lower serum lipid levels. PMID: 22883088
    9. COG directly and positively regulates endosome-to-TGN retrograde transport by specific and direct interaction with the t-SNARE Stx6 via its Cog6 subunit. PMID: 21807881
    10. This paper reports a new congenital disorder caused by mutations in the human COG8 gene and describes the affect this mutation has on the other COG components. PMID: 17331980

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  • 相關疾病:
    Congenital disorder of glycosylation 2L (CDG2L); Shaheen syndrome (SHNS)
  • 亞細胞定位:
    Golgi apparatus membrane; Peripheral membrane protein.
  • 蛋白家族:
    COG6 family
  • 數據庫鏈接:

    HGNC: 18621

    OMIM: 606977

    KEGG: hsa:57511

    STRING: 9606.ENSP00000397441

    UniGene: Hs.507805



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