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  4. CNTN6 Antibody

CNTN6 Antibody

  • 中文名稱：
    CNTN6兔多克隆抗體
  • 貨號：
    CSB-PA008872
  • 規格：
    ￥1090
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    CNTN6
  • 別名：
    CNTN 6 antibody; CNTN6 antibody; CNTN6_HUMAN antibody; Contactin 6 precursor antibody; Contactin-6 antibody; Contactin6 antibody; hNB 3 antibody; hNB-3 antibody; hNB3 antibody; MGC133256 antibody; NB 3 antibody; NB3 antibody; Neural adhesion molecule antibody; Neural recognition molecule NB 3 antibody; Neural recognition molecule NB-3 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Contactin 6.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:40000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Contactins mediate cell surface interactions during nervous system development. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Involved in motor coordination.
  • 基因功能參考文獻：
    1. Clinical investigations of the patients carrying CNTN5 or CNTN6 variants showed that they were hypersensitive to sounds (a condition called hyperacusis) and displayed changes in wave latency within the auditory pathway. PMID: 27166760
    2. CNTN6 copy number variants (duplications) were associated with increased risk of Tourette syndrome. PMID: 28641109
  • 亞細胞定位：
    Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族：
    Immunoglobulin superfamily, Contactin family
  • 組織特異性：
    Expressed in nervous system. Highly expressed in cerebellum. Expressed at intermediate level in thalamus, subthalamic nucleus. Weakly expressed in corpus callosum, caudate nucleus and spinal cord.
  • 數據庫鏈接：

    HGNC: 2176

    OMIM: 607220

    KEGG: hsa:27255

    STRING: 9606.ENSP00000341882

    UniGene: Hs.387300



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