在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CNOT2 (Ab-101) Antibody

  • 中文名稱:
    CNOT2 (Ab-101)兔多克隆抗體
  • 貨號:
    CSB-PA951939
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from HepG2 cells, treated with starved (24hours), using CNOT2 (Ab-101) antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CNOT2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CNOT2
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized non-phosphopeptide derived from Human CNOT2 around the phosphorylation site of serine 101 (S-L-S(p)-Q-G).
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity.
  • 基因功能參考文獻:
    1. CNOT2 promotes proliferation and angiogenesis via VEGF signaling in MDA-MB-231 breast cancer cells. PMID: 29024811
    2. ERG is recruited to mRNAs via interaction with the RNA-binding protein RBPMS, and it promotes mRNA decay by binding CNOT2, a component of the CCR4-NOT deadenylation complex. PMID: 27273514
    3. The CNOT2-CNOT3 heterodimer is stabilized and tightly anchored to the surface of CNOT1 through an unexpected intertwined arrangement of peptide regions lacking defined secondary structure. PMID: 24121232
    4. Cnot1, Cnot2, and Cnot3 represent a novel component of the core self-renewal and pluripotency circuitry conserved in mouse and human ESCs. PMID: 22367759
    5. human CNOT2 is important for maintaining the deadenylase activity and structural integrity of the CCR4-NOT complex, thereby affecting cell viability. PMID: 21299754
    6. This study shows that SMRT/NCoR-HDAC3 complex is a cofactor of CNOT2-mediated repression and suggests that transcriptional regulation by the Ccr4-Not complex involves regulation of chromatin modification. PMID: 16712523
    7. major repression function of CNOT2 is localized in a specialized protein motif, the Not-Box PMID: 14707134
    8. These findings suggest that CDK11 may contribute to apoptosis by regulating the activity of NOT2 independent of its kinase activity. PMID: 16039607

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus.
  • 蛋白家族:
    CNOT2/3/5 family
  • 組織特異性:
    Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes.
  • 數據庫鏈接:

    HGNC: 7878

    OMIM: 604909

    KEGG: hsa:4848

    STRING: 9606.ENSP00000229195

    UniGene: Hs.133350



主站蜘蛛池模板: 久久久无码精品亚洲日韩啪啪网站 | 超caopor在线公开视频| 久久婷婷是五月综合色| 男人j进入女人j内部免费网站| 国产精品久免费的黄网站| 国产成人精品福利一区二区三区| 亚洲 制服丝袜 中文字幕 在线| 国产鲁鲁视频在线观看| 亚洲日韩乱码久久久久久| 日本一区二区三区免费更新不卡 | 宅男色影视亚洲人在线| 成年美女黄网站色大免费全看| 色妞色视频一区二区三区四区| 亚洲精品制服丝袜四区| 亚洲国产精品无码一区二区三区| 全国最大成人网| 成在线人免费无码高潮喷水| 粉嫩虎白女毛片人体| 婷婷综合缴情亚洲| 亚洲色大成网站www永久| 日本老熟妇乱| 137日本免费肉体摄影| 九九久久精品国产| 日本被黑人强伦姧人妻完整版| 日本丰满熟妇videossex| 国产三级视频在线播放线观看| 国产成人无码一二三区视频| 久久久久久国产精品无码超碰| 亚洲大成色www永久网站动图| 亚洲成_人网站图片| 又粗又硬又大又爽免费视频播放| 欧美孕妇乳喷奶水在线观看| 女人与公拘交酡全过程| 亚洲精品一区二区三区中文字幕 | 日产精品1区2区3区| 特级西西人体444www高清大胆| 亚洲乱亚洲乱少妇无码99p| 成人无码免费视频在线播| 国产精品自在拍首页视频| 狠狠88综合久久久久综合网| 亚洲另类无码专区丝袜|