在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CNOT2 (Ab-101) Antibody

CNOT2 (Ab-101) Antibody

  • 中文名稱：
    CNOT2 (Ab-101)兔多克隆抗體
  • 貨號：
    CSB-PA951939
  • 規格：
    ￥2024
  • 圖片：
    • Western blot analysis of extracts from HepG2 cells, treated with starved (24hours), using CNOT2 (Ab-101) antibody.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CNOT2 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CNOT2
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Synthesized non-phosphopeptide derived from Human CNOT2 around the phosphorylation site of serine 101 (S-L-S(p)-Q-G).
  • 免疫原種屬：
    Homo sapiens (Human)
  • 克隆類型：
    Polyclonal
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:3000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specifically involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of embryonic stem (ES) cell identity.
  • 基因功能參考文獻：
    1. CNOT2 promotes proliferation and angiogenesis via VEGF signaling in MDA-MB-231 breast cancer cells. PMID: 29024811
    2. ERG is recruited to mRNAs via interaction with the RNA-binding protein RBPMS, and it promotes mRNA decay by binding CNOT2, a component of the CCR4-NOT deadenylation complex. PMID: 27273514
    3. The CNOT2-CNOT3 heterodimer is stabilized and tightly anchored to the surface of CNOT1 through an unexpected intertwined arrangement of peptide regions lacking defined secondary structure. PMID: 24121232
    4. Cnot1, Cnot2, and Cnot3 represent a novel component of the core self-renewal and pluripotency circuitry conserved in mouse and human ESCs. PMID: 22367759
    5. human CNOT2 is important for maintaining the deadenylase activity and structural integrity of the CCR4-NOT complex, thereby affecting cell viability. PMID: 21299754
    6. This study shows that SMRT/NCoR-HDAC3 complex is a cofactor of CNOT2-mediated repression and suggests that transcriptional regulation by the Ccr4-Not complex involves regulation of chromatin modification. PMID: 16712523
    7. major repression function of CNOT2 is localized in a specialized protein motif, the Not-Box PMID: 14707134
    8. These findings suggest that CDK11 may contribute to apoptosis by regulating the activity of NOT2 independent of its kinase activity. PMID: 16039607

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 蛋白家族：
    CNOT2/3/5 family
  • 組織特異性：
    Ubiquitous. Highly expressed in brain, heart, thymus, spleen, kidney, liver, small intestine, placenta, lung and peripheral blood leukocytes.
  • 數據庫鏈接：

    HGNC: 7878

    OMIM: 604909

    KEGG: hsa:4848

    STRING: 9606.ENSP00000229195

    UniGene: Hs.133350



主站蜘蛛池模板： 国产情侣激情在线视频| 国产美女被遭强高潮免费网站| 国内揄拍国内精品人妻| 2020精品国产视| 亚洲欧洲中文日韩乱码av| 国产精品夜夜春夜夜爽久久小说| 日本又色又爽又黄的视频免| 欧美性猛交xxx嘿人猛交| 国产在线观看无码不卡 | 久久精品国产免费播| 国产成人无码一区二区三区在线| 99精品国产在热久久无码| 动漫av永久无码精品每日更新| 公与淑婷厨房猛烈进出视频免费| 亚洲精品美女久久久久久久 | 高清同性男毛片| 五十路熟妇强烈无码| 精品无人码麻豆乱码1区2区| 久久www免费人成精品| 国产在线观看片a免费观看| 牲交a欧美牲交aⅴ免费一| 中文字幕人妻丝袜乱一区三区| 国产成人无码av在线播放dvd| 性欧美牲交在线视频| 少妇被粗大的猛烈进出动视频| 自拍偷自拍亚洲精品情侣| 婷婷无套内射影院| 午夜福利18以下勿进免费| 久久九九国产精品怡红院| 情侣黄网站免费看| 国产熟女亚洲精品麻豆| 国产成人8x人网站视频在线观看| 99精品众筹模特自拍视频| 日韩一区二区三区精品| 在教室伦流澡到高潮hgl动漫| 国产在线不卡精品网站| 无码中文字幕日韩专区视频| 丰满少妇高潮惨叫久久久一| 丁香婷婷六月综合交清| 虎白女粉嫩尤物福利视频 | 国语少妇高潮对白在线|