在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CNMD Antibody, FITC conjugated

CNMD Antibody, FITC conjugated

  • 中文名稱：
    CNMD兔多克隆抗體, FITC偶聯
  • 貨號：
    CSB-PA012854LC01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CNMD Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CNMD
  • 別名：
    BRICD3 antibody; BRICHOS domain containing 3 antibody; CH-SP antibody; CHM I antibody; ChM-I antibody; CHM1 antibody; chondromodulin antibody; Chondromodulin I antibody; Chondromodulin-1 antibody; Chondromodulin-I antibody; Chondrosurfactant protein antibody; LECT 1 antibody; Lect1 antibody; LECT1_HUMAN antibody; Leukocyte cell derived chemotaxin 1 antibody; Multiple myeloma tumor suppressor 1 antibody; MYETS1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Leukocyte cell-derived chemotaxin 1 protein (215-334AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    FITC
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization.
  • 基因功能參考文獻：
    1. ChMI directly suppressed the proliferation and growth of osteosarcoma cells. PMID: 28983591
    2. CHM1 seems to have pleiotropic functions in Ewing sarcoma. PMID: 28319320
    3. The results of the present study indicated that ChMI was able to inhibit the growth of breast cancer cells; thus suggesting that ChM-I may have potential clinical applications in the treatment of breast cancer. PMID: 27035228
    4. Data suggest ChM1 as potential tumor suppressor in gastric cancer and useful biomarker for the treatment and prognosis. Its expression was downregulated in cancer tissue, and correlated with advanced stages, lymph node metastasis, and poorer prognosis. PMID: 26165347
    5. intact 20-25 kDa ChM-I is stored as a component of extracellular matrix in the avascular cartilage zones, but it is inactivated by a single N-terminal proteolytic cleavage in the hypertrophic zone of growth-plate cartilage PMID: 24710035
    6. the inner meniscus contained larger amounts of ChM-I, and that the inner meniscus-derived ChM-I inhibited endothelial cell proliferation. PMID: 23143879
    7. Degenerative intervertebral disc cells express ChM-I. Administration of bFGF down-regulates the expression of ChM-I. Expression is correlated with the degree of degeneration. PMID: 22041680
    8. Inhibition of YY1 in combination with forced expression of p300 and Sp3 restored the expression of ChM-I in cells with a hypomethylated promoter region, but not in cells with hypermethylation. PMID: 20663886
    9. Data suggest that chondromodulin-I impairs the VEGF-A-stimulated motility of endothelial cells by destabilizing lamellipodial extensions. PMID: 20026108
    10. Methylation in the core-promoter region of the chondromodulin-I gene determines the cell-specific expression by regulating the binding of transcriptional activator Sp3 PMID: 15107420
    11. chondromodulin-I has a pivotal role in maintaining valvular normal function by preventing angiogenesis that may lead to valvular heart diseases PMID: 16980969
    12. Cell-specific epigenetic regulation of ChM-I gene expression PMID: 17980151
    13. new hypoxia-inducible and SOX9-regulated genes, Gdf10 and Chm-I. In addition, Mig6 and InhbA were induced by hypoxia, predominantly via HIF-2alpha PMID: 18077449

    顯示更多

    收起更多

  • 亞細胞定位：
    [Chondromodulin-1]: Secreted, extracellular space, extracellular matrix. Note=Accumulated in the inter-territorial matrix of cartilage.; [Chondrosurfactant protein]: Endomembrane system; Single-pass membrane protein.
  • 蛋白家族：
    Chondromodulin-1 family
  • 組織特異性：
    Detected in cartilage and cardiac valves (at protein level). Detected in the laminae fibrosa, spongiosa and ventricularis layers of normal cardiac valves (at protein level). Expression is decreased cardiac valves of patients with valvular heart disease (a
  • 數據庫鏈接：

    HGNC: 17005

    OMIM: 605147

    KEGG: hsa:11061

    STRING: 9606.ENSP00000367198

    UniGene: Hs.421391



主站蜘蛛池模板： 一区二三区国产好的精华液o9| 女人裸体性做爰视频| 国产成人免费97在线| 免费看女人与公拘交酡过程| 国产福利免费视频不卡| 精品国产人妻一区二区三区| 成av人片在线观看www| 男女下面一进一出好爽视频| 丰满少妇被猛烈进av毛片| 国产精品成人av片免费看| 亚洲国色天香卡2卡3卡4| 99久久免费国产精品| 狠狠色丁香久久综合| 欧美俄罗斯乱妇| 中文人妻av久久人妻18| 国产ktv交换配乱婬视频| 男女18禁啪啪无遮挡激烈网站| 又大又长粗又爽又黄少妇视频 | 2020国产欧洲精品网站| 亚洲大尺度专区无码浪潮av| 男人添女人囗交做爰视频| 欧美巨鞭大战丰满少妇| 国产清纯在线一区二区www| 国内久久婷婷六月综合欲色啪| 欧美性猛交ⅹxxx乱大交妖精| 99久久精品美女高潮喷水| 韩国久久久久久级做爰片| 老头把我添高潮了a片| 又粗又大又硬又长又爽| 午夜男女无遮挡拍拍视频| 国产亚洲精品久久一区二区| 色妺妺在线视频| 亚洲国产成人综合一区二区三区| 人妻少妇无码精品专区| 国产精品无码一本二本三本色 | 激情无码人妻又粗又大中国人| 久久成人a毛片免费观看网站 | 无码中文字幕日韩专区视频 | 丰满熟妇乱子伦| 一二三四在线观看免费视频| 亚洲国产成人超a在线播放|