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  4. CNKSR3 Antibody, HRP conjugated

CNKSR3 Antibody, HRP conjugated

  • 中文名稱：
    CNKSR3兔多克隆抗體, HRP偶聯
  • 貨號：
    CSB-PA757602LB01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CNKSR3 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CNKSR3
  • 別名：
    CNKSR3 antibody; MAGI1Connector enhancer of kinase suppressor of ras 3 antibody; Connector enhancer of KSR 3 antibody; CNK homolog protein 3 antibody; CNK3 antibody; CNKSR family member 3 antibody; Maguin-like protein antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Connector enhancer of kinase suppressor of ras 3 protein (301-555AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Involved in transepithelial sodium transport. Regulates aldosterone-induced and epithelial sodium channel (ENaC)-mediated sodium transport through regulation of ENaC cell surface expression. Acts as a scaffold protein coordinating the assembly of an ENaC-regulatory complex (ERC).
  • 基因功能參考文獻：
    1. SCAF8-CNKSR3 variant rs955333 was not associated with diabetic kidney disease but showed association with diabetic retinopathy in Chinese type 2 diabetes patients PMID: 28401168
    2. Cox regression and Kaplan-Meier survival analysis identified that amplification of the CNKSR3 gene (log-rank, P = 0.022) with an associated increase in its protein expression (log-rank, P = 0.011) correlated with longer patient survival. PMID: 23357503
    3. CNK3 is a molecular scaffold, which coordinates the assembly of a multiprotein ENaC-regulatory complex and hence plays a central role in Na(+) homeostasis. PMID: 22851176
    4. two gene markers (CNKSR3 and SPTBN2) differentiate between aspirin-exacerbated respiratory disease and aspirin-tolerant asthma with a perfect discriminative power PMID: 22457146
    5. CNK3 and IPCEF1 produce a single protein that is required for HGF dependent Arf6 activation and migration. PMID: 22085542
    6. CNKSR3, a homologue of scaffold proteins involved in MAPK pathway regulation, is a direct target of MR and is required for the maintenance of transepithelial sodium transport in the kidney. PMID: 19567370

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  • 亞細胞定位：
    Cytoplasm. Apical cell membrane; Peripheral membrane protein.
  • 蛋白家族：
    CNKSR family
  • 數據庫鏈接：

    HGNC: 23034

    OMIM: 617476

    KEGG: hsa:154043

    STRING: 9606.ENSP00000356182

    UniGene: Hs.16064



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