在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CNDP1 Antibody

  • 中文名稱:
    CNDP1兔多克隆抗體
  • 貨號:
    CSB-PA836242ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: Beta-Ala-His dipeptidase antibody at 4μg/ml
      Lane 1: 293T whole cell lysate
      Lane 2: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 57 kDa
      Observed band size: 57 kDa
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA836242ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CNDP1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CNDP1
  • 別名:
    Beta Ala His dipeptidase antibody; Beta-Ala-His dipeptidase antibody; Carnosinase 1 antibody; Carnosinase1 antibody; Carnosine dipeptidase 1 (metallopeptidase M20 family) antibody; Carnosine dipeptidase 1 antibody; CN1 antibody; CNDP 1 antibody; CNDP dipeptidase 1 antibody; Cndp1 antibody; CNDP1_HUMAN antibody; CPGL2 antibody; Glutamate carboxypeptidase like protein 2 antibody; Glutamate carboxypeptidase-like protein 2 antibody; HsT2308 antibody; MGC102737 antibody; MGC10825 antibody; MGC142072 antibody; OTTHUMP00000163751 antibody; Serum carnosinase antibody; UNQ1915/PRO4380 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Beta-Ala-His dipeptidase protein (1-280AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Catalyzes the peptide bond hydrolysis in Xaa-His dipeptides, displaying the highest activity toward carnosine (beta-alanyl-L-histidine) and anserine (beta-alanyl-3-methyl-histidine).
  • 基因功能參考文獻:
    1. The distribution of the (CTG)5 homozygous genotype in the no-diabetic nephropathy (DN) and clinical-DN patients was comparable, a lower frequency was found in the biopsy proven-DN patients, particularly in females. We observed a significant trend towards high frequencies of the (CTG)5 homozygous genotype with increased time on dialysis. PMID: 28553654
    2. Considering that approximately 40 per cent of the population are homozygous for the 5L allele of (CTG) n repeat polymorphism in CNDP1 gene and seem to be less prone to develop DN, it is needed to evaluate whether the majority of diabetic patients (who do not have the 5L-5L genotype) would be benefited from supplementation with carnosine or with a more intensive monitoring PMID: 27834319
    3. Compared to healthy individuals and those with diabetes but no kidney disease, patients with diabetic nephropathy exhibited lower frequencies of 5L-5L genotype and 5L allele of CNDP1 gene, suggesting that this allele might confer protection against development of kidney disease in this population. PMID: 27834323
    4. genetic association studies in pediatric population in Germany: Data suggest that, in pediatric patients with chronic kidney disease, the nephroprotective effect of CNDP1 Mannheim genetic variant against disease progression is not restricted to patients with diabetic nephropathy. PMID: 27278783
    5. The experimentally measured higher affinity of homocarnosine for the enzyme relative to l-carnosine might be explained, at least in part, by more extensive interactions inside the monomeric and dimeric hCN1's active site. PMID: 27105448
    6. Data shows that higher carnosine content in human skeletal muscle is positively associated with insulin resistance and fasting metabolic preference for glucose. PMID: 26439389
    7. In gastrointestinal cancer, reduced plasma levels of CNDP1 associate with signs of catabolism and poor outcome. PMID: 25898255
    8. Alterations of serum carnosinase (CN1) activity has been associated with several pathological conditions, such as neurological disorders, chronic diseases and cancer PMID: 24566305
    9. This meta-analysis confirms that the carnosinase D18S880 microsatellite polymorphism is associated with daibetic nephropathy susceptibility, especially in the type 2 DM and the Caucasian population. PMID: 23402577
    10. Rs12604675-A in CNDP1 may confer susceptibility to overt proteinuria in Japanese women with type 2 diabetes. PMID: 23342076
    11. In this review, correlations between serum carnosine and carnosinase activity and polymorphism in CNDP1 gene are analyzed. The role of CNDP1 gene polymorphism the development of diabetic nephropathy and non-diabetic chronic kidney disease is discussed. PMID: 22706107
    12. Plasma levels of FLT and S100A9 proteins are up-regulated and CNDP1 levels are down-regulated in patients with glioblastoma. PMID: 23029420
    13. These findings provide nominal evidence supporting a role between CNDP1 variants and diabetic kidney disease. PMID: 21393041
    14. neither CNDP1 genotype nor the normal variation in circulating testosterone levels affects the muscular carnosine content PMID: 20865290
    15. Serum histidine dipeptide concentrations are not correlated to serum carnosinase activity PMID: 20971102
    16. CNDP1 polymorphism predicts progression to ESRD in patients with diabetic nephropathies, but only late after baseline measurements. PMID: 20711718
    17. CTG polymorphism of the CNDP1 gene does not affect survival of Chinese peritoneal dialysis subjects. PMID: 20979941
    18. Hyperglycemia enhances CNDP1 secretion and enzyme activity; data suggest that poor blood glucose control in diabetic patients might result in an increased enzyme secretion even in the presence of the (CTG)(5) allele. PMID: 20460427
    19. Association between the CNDP1 gene and diabetic nephropathy is sex specific and independent of susceptibility for type 2 diabetes. PMID: 20332346
    20. GCP II mRNA was detected in glial cells. Glial-rich regions, specifically the DLPFC and ERC white matter and the molecular and polymorphic layers in the hippocampus, express high levels of GCP II mRNA. PMID: 14560319
    21. diabetic patients with the carnosinase CNDP1 gene Mannheim variant are less susceptible for nephropathy PMID: 16046297
    22. no difference in allele or genotype frequency between centenarians & controls or between cardiovascular patients & controls; the recently identified functional carnosinase variant does not contribute to longevity or protect against coronary heart disease PMID: 16965804
    23. CPGL-B may be associated with cell growth and metastasis of HCC. PMID: 17121880
    24. This replicates the CNDP1 gene association with diabetic nephropathy (DN) that was initially detected in European Caucasians and in Arabs, and further demonstrates that the CNDP1 gene and carnosine pathway appear to play a role in susceptibility to DN. PMID: 17205963
    25. Diabetic patients homozygous for CNDP1 are protected against diabetic nephropathy. PMID: 17601991
    26. CN1-dependent susceptibility to diabetic nephropathy may at least in part be mediated by altered glucose metabolism in type 2 diabetic patients. PMID: 17601992
    27. South Asian Surinamese have a lower frequency of the 5/5 homozygous genotype, which was associated with lower carnosinase activity and genetic risk for developing diabetic nephropathy. PMID: 19577318

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    Peptidase M20A family
  • 組織特異性:
    Found in serum and adult nervous central system. Absent in serum from patients with homocarnosinosis.
  • 數據庫鏈接:

    HGNC: 20675

    OMIM: 609064

    KEGG: hsa:84735

    STRING: 9606.ENSP00000351682

    UniGene: Hs.400613



主站蜘蛛池模板: 亚洲熟女www一区二区三区| 免费观看又色又爽又湿的软件 | 国产超碰无码最新上传| 亚洲乱亚洲乱妇无码麻豆| 久久亚洲国产精品五月天婷| 久久精品99久久香蕉国产色戒| 亚洲福利国产网曝| 国产片a国产片免费看视频| 顶级少妇做爰视频在线观看| 老熟妇高潮一区二区三区| 中国精品偷拍区偷拍无码| 亚洲男人的天堂在线va| 日韩人妻精品无码一区二区三区| 久久人人妻人人做人人爽| av无码久久久久不卡蜜桃| yy111111少妇影院无码| 无码成人精品区在线观看| 天堂资源中文网| 国产重口老太和小伙乱| 综合亚洲综合图区网友自拍 | 色欧美片视频在线观看| 99精品国产在热久久| 西西人体大胆啪啪实拍| 无码专区—va亚洲v专区| 国产亚洲精品久久久久久青梅| 一本久道久久综合狠狠躁av| 插插插精品亚洲一区| 国产在线精品二区| 成人午夜又粗又硬又长| 国产又粗又猛又爽的视频a片| 精品久久久久久中文字幕大豆网 | 虎白女粉嫩尤物福利视频| 国产精品一国产精品| 天堂а√中文在线| 特级毛片a片久久久久久| 中文字幕在线观看亚洲日韩| 国产毛片一区二区精品| 一本一本久久a久久精品综合麻豆| 另类内射国产在线| 久久亚洲精品国产精品婷婷| 国产乱辈通伦影片在线播放亚洲 |