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CMTM4 Antibody

  • 中文名稱:
    CMTM4兔多克隆抗體
  • 貨號:
    CSB-PA007375
  • 規格:
    ¥1090
  • 圖片:
    • Western Blot analysis of HELA cells using CMTM4 Polyclonal Antibody
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CMTM4
  • 別名:
    CMTM4; CKLFSF4; CKLF-like MARVEL transmembrane domain-containing protein 4; Chemokine-like factor superfamily member 4
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse
  • 免疫原:
    Synthesized peptide derived from the Internal region of Human CMTM4.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    WB, IHC, ELISA
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:100-1:300
    ELISA 1:40000
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Acts as a backup for CMTM6 to regulate plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. May protect PD-L1/CD274 from being polyubiquitinated and targeted for degradation.
  • 基因功能參考文獻:
    1. CMTM4 is downregulated and exhibits tumour-suppressor activities in clear cell renal cell carcinoma, and could be exploited as a target for clear cell renal cell carcinoma treatment. PMID: 26474560
    2. Data show that CMTM4 might be an important gene involved in cell growth and cell cycle regulation. PMID: 20213316
  • 亞細胞定位:
    Membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Chemokine-like factor family
  • 組織特異性:
    Highly expressed in testis and prostate.
  • 數據庫鏈接:

    HGNC: 19175

    OMIM: 607887

    KEGG: hsa:146223

    STRING: 9606.ENSP00000333833

    UniGene: Hs.643961



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