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  4. CLYBL Antibody

CLYBL Antibody

  • 中文名稱：
    CLYBL兔多克隆抗體
  • 貨號：
    CSB-PA850772LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Western Blot
      Positive WB detected in: Hela whole cell lysate, Jurkat whole cell lysate, THP-1 whole cell lysate, HepG2 whole cell lysate, NIH/3T3 whole cell lysate
      All lanes: CLYBL antibody at 1:1000
      Secondary
      Goat polyclonal to rabbit IgG at 1/50000 dilution
      Predicted band size: 38, 34 KDa
      Observed band size: 38 KDa
      Exposure time：5min
    • IHC image of CSB-PA850772LA01HU diluted at 1:50 and staining in paraffin-embedded human liver tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at 37℃ Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a Goat anti-Mouse IgG labeled by HRP and visualized using 0.05% DAB.
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CLYBL Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CLYBL
  • 別名：
    CLYBL antibody; CLB antibody; Citramalyl-CoA lyase antibody; mitochondrial antibody; EC 4.1.3.25; antibody; 3S)-malyl-CoA thioesterase antibody; EC 3.1.2.30 antibody; Beta-methylmalate synthase antibody; EC 2.3.3.- antibody; Citrate lyase subunit beta-like protein antibody; Citrate lyase beta-like antibody; Malate synthase antibody; EC 2.3.3.9 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human Citrate lyase subunit beta-like protein, mitochondrial protein
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，CLYBL Antibody (CSB-PA850772LA01HU)，的標記方式是Non-conjugated。對于CLYBL Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA850772LB01HU CLYBL Antibody, HRP conjugated ELISA
    FITC CSB-PA850772LC01HU CLYBL Antibody, FITC conjugated
    Biotin CSB-PA850772LD01HU CLYBL Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Mitochondrial citramalyl-CoA lyase indirectly involved in the vitamin B12 metabolism. Converts citramalyl-CoA into acetyl-CoA and pyruvate in the C5-dicarboxylate catabolism pathway. The C5-dicarboxylate catabolism pathway is required to detoxify itaconate, a vitamin B12-poisoning metabolite. Also acts as a malate synthase in vitro, converting glyoxylate and acetyl-CoA to malate. Also displays malyl-CoA thioesterase activity. Also acts as a beta-methylmalate synthase in vitro, by mediating conversion of glyoxylate and propionyl-CoA to beta-methylmalate. Also has very weak citramalate synthase activity in vitro.
  • 基因功能參考文獻：
    1. Study reports that CLYBL loss leads to a cell-autonomous defect in the mitochondrial B12 metabolism and that itaconyl-CoA is a cofactor-inactivating, substrate-analog inhibitor of the mitochondrial B12-dependent methylmalonyl-CoA mutase PMID: 29056341
  • 亞細胞定位：
    Mitochondrion.
  • 蛋白家族：
    HpcH/HpaI aldolase family, Citrate lyase beta subunit-like subfamily
  • 數據庫鏈接：

    HGNC: 18355

    OMIM: 609686

    KEGG: hsa:171425

    STRING: 9606.ENSP00000342991

    UniGene: Hs.655642



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