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  4. CLUAP1 Antibody

CLUAP1 Antibody

  • 中文名稱：
    CLUAP1兔多克隆抗體
  • 貨號：
    CSB-PA836181LA01HU
  • 規格：
    ￥440
  • 圖片：
    • Immunohistochemistry of paraffin-embedded human prostate cancer using CSB-PA836181LA01HU at dilution of 1:100
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CLUAP1 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CLUAP1
  • 別名：
    CLUA1_HUMAN antibody; Cluap1 antibody; Clusterin associated protein 1 antibody; Clusterin-associated protein 1 antibody; FLJ13297 antibody; KIAA0643 antibody; Qilin antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Clusterin-associated protein 1 protein (161-413AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated

    本頁面中的產品，CLUAP1 Antibody (CSB-PA836181LA01HU)，的標記方式是Non-conjugated。對于CLUAP1 Antibody，我們還提供其他標記。見下表：

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA836181LB01HU CLUAP1 Antibody, HRP conjugated ELISA
    FITC CSB-PA836181LC01HU CLUAP1 Antibody, FITC conjugated
    Biotin CSB-PA836181LD01HU CLUAP1 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Required for cilia biogenesis. Appears to function within the multiple intraflagellar transport complex B (IFT-B). Key regulator of hedgehog signaling.
  • 基因功能參考文獻：
    1. Two variants in CLUAP1 were identified through exome-sequence analysis, Chr16:g.3558407T>G, c.338T>G, p.(Met113Arg) and Chr16:g.3570011C>T, c.688C>T, p.(Arg230Ter). he genetic data show that these variants are present in an affected child, are rare in the population, and result in reduced, but not absent, intraflagellar transport. PMID: 28679688
    2. Consistent with the knowledge that CLUAP1 plays an important role in cilia function and that cilia are critical to photoreceptor function, our results indicate that hypomorphic mutations in CLUAP1 can result in dysfunctional photoreceptors without systemic abnormalities. This is the first report linking mutations in CLUAP1 to human disease and establishes CLUAP1 as a candidate Leber congenital amaurosis gene PMID: 26820066
    3. inactivation of CLUAP1 may conceivably serve in the future as a novel therapeutic intervention for treatment of colon cancer PMID: 15480429
    4. CLUAP1 (clusterin-associated protein 1) is highly expressed in osteosarcoma, ovarian, colon, and lung cancers PMID: 17203229
  • 亞細胞定位：
    Cell projection, cilium. Nucleus.
  • 蛋白家族：
    CLUAP1 family
  • 組織特異性：
    Expressed in testis, thyroid and trachea and to a lower extent in spinal cord and adrenal gland. Highly expressed in colon cancer and osteosarcoma cell lines.
  • 數據庫鏈接：

    HGNC: 19009

    KEGG: hsa:23059

    STRING: 9606.ENSP00000460850

    UniGene: Hs.155995



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