在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CLN5 Antibody

CLN5 Antibody

  • 中文名稱：
    CLN5兔多克隆抗體
  • 貨號：
    CSB-PA005567LA01HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • IHC image of CSB-PA005567LA01HU diluted at 1:300 and staining in paraffin-embedded human prostate tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • IHC image of CSB-PA005567LA01HU diluted at 1:300 and staining in paraffin-embedded human colon cancer performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.
    • Immunofluorescence staining of 293T cells with CSB-PA005567LA01HU at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CLN5 Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CLN5
  • 別名：
    Ceroid lipofuscinosis neuronal 5 antibody; Ceroid-lipofuscinosis neuronal protein 5 antibody; CLN5 antibody; CLN5_HUMAN antibody; NCL antibody; Protein CLN5 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Ceroid-lipofuscinosis neuronal protein 5 protein (42-181AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated

    本頁面中的產(chǎn)品，CLN5 Antibody (CSB-PA005567LA01HU)，的標(biāo)記方式是Non-conjugated。對于CLN5 Antibody，我們還提供其他標(biāo)記。見下表：

    可提供標(biāo)記
    標(biāo)記方式 貨號 產(chǎn)品名稱 應(yīng)用
    HRP CSB-PA005567LB01HU CLN5 Antibody, HRP conjugated ELISA
    FITC CSB-PA005567LC01HU CLN5 Antibody, FITC conjugated
    Biotin CSB-PA005567LD01HU CLN5 Antibody, Biotin conjugated ELISA
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, IHC, IF
  • 推薦稀釋比：
    Application Recommended Dilution
    IHC 1:200-1:500
    IF 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.
  • 基因功能參考文獻：
    1. Genotype-phenotype correlation between CNL5 gene mutations and CNL5 disease symptoms. PMID: 28542837
    2. We conclude that, whereas sleep homeostasis is present in CLN5(-/-) sheep, underlying CLN5(-/-) disease processes prevent its full expression, even at early stages. PMID: 27488642
    3. findings support CLN5 hypomorphic mutations cause autosomal recessive cerebellar ataxia, confirming other reports showing CLN mutations are associated with adult-onset neurodegenerative disorders PMID: 25359263
    4. Two forms of CLN5, derived from the C-terminal proteolytic processing, are present in most cells and tissues. PMID: 26342652
    5. There are functional differences in various N-glycosylation sites of CLN5 which affect folding, trafficking, and lysosomal function of CLN5. PMID: 24058541
    6. a role for CLN5 in controlling the itinerary of the lysosomal sorting receptors by regulating retromer recruitment at the endosome PMID: 22431521
    7. This study highlights a close interaction between CLN5/CLN8 proteins, and their role in sphingolipid metabolism. Our findings suggest that CLN5p/CLN8p most likely are positive modulators of CerS1 and/or CerS2. PMID: 23160995
    8. analysis of mutations in neuronal ceroid lipofuscinosis protein CLN5 PMID: 20052765
    9. CLN5 mutations are 1) more common in patients with neuronal ceroid lipofuscinosis (NCL) than previously reported, 2) found in patients of broad ethnic diversity, and 3) can be identified in patients with disease onset in adult and juvenile epochs PMID: 20157158
    10. Study found that CLN5 interacts with several other NCL proteins namely, CLN1/PPT1, CLN2/TPP1, CLN3, CLN6 and CLN8. PMID: 19941651
    11. biosynthesis and intracellular localization of this protein PMID: 11971870
    12. A novel missense mutation in CLN5 was found in a Colombian family with juvenile-onset neuronal ceroid lipofuscinosis: c. 1627G>A causing Arg112His. PMID: 15728307
    13. The CLN5/mRNA expression level reduced to 45% supports the existence of one mRNA non-producing allele, further noticeable at the protein level. PMID: 16814585
    14. Reports two sibs harbouring a novel mutation (p.Tyr258Asp) in the CLN5 gene and displaying behaviour disturbances and mental deterioration, rather than epilepsy, as the dominant disease manifestation at onset. PMID: 17607606
    15. In cultures of brain microvascular endothelial cells, VEGF-A specifically down-regulated CLN-5 and OCLN protein and mRNA PMID: 19174516
    16. Double immunofluorescence microscopy showed that while the wild-type CLN5 protein is localized in lysosomes, both mutant CLN5 proteins are retained in the endoplasmic reticulum rather than reaching the lysosome. PMID: 19309691

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Ceroid lipofuscinosis, neuronal, 5 (CLN5)
  • 亞細(xì)胞定位：
    [Ceroid-lipofuscinosis neuronal protein 5, secreted form]: Lysosome.; [Ceroid-lipofuscinosis neuronal protein 5]: Membrane; Single-pass type II membrane protein.
  • 蛋白家族：
    CLN5 family
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2076

    OMIM: 256731

    KEGG: hsa:1203

    STRING: 9606.ENSP00000366673

    UniGene: Hs.30213



主站蜘蛛池模板： 国产成人亚洲精品无码青青草原| 成人乱人伦视频在线观看| 久久婷婷丁香七月色综合| 性按摩无码中文| 大肉大捧一进一出好爽视频mba | 久久丫精品忘忧草西安产品| 国产精品96久久久久久| 国产人无码a在线西瓜影音| 欧美精品一产区二产区| 天美麻花果冻视频大全英文版 | 狠狠色噜噜狠狠狠7777米奇| 国产精品天天看特色大片| 亚洲第一无码精品立川理惠| 日本黄页网站免费观看| 55夜色66夜色国产精品视频| 真实国产熟睡乱子伦视频| 亚洲第一aaaaa片| 亚洲精品无码mv在线观看| 国产亚洲日韩妖曝欧美| 无码人妻丰满熟妇区96| 波多野结衣一区二区三区高清av| 成人精品视频在线观看不卡| 精品无码国产自产在线观看水浒传| 成人动漫综合网| 欧美大黑帍在线播放| 国产精品爽爽ⅴa在线观看| 浴室人妻的情欲hd三级国产| 欧美成人午夜免费全部完| 久久97久久97精品免视看秋霞| av无码av不卡一区二区| 国模精品一区二区三区| 不卡无码av一区二区三区 | 亚洲精品少妇一区二区| 国产suv精品一区二区62| 国产探花在线精品一区二区| 亚洲精品无码乱码成人| 无码孕妇孕交在线观看| 性色av极品无码专区亚洲| 中文字幕乱码亚洲无线码三区| 国产精品麻豆成人av电影艾秋| 初尝人妻少妇中文字幕|