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CLIP2 Antibody

  • 中文名稱：
    CLIP2兔多克隆抗體
  • 貨號(hào)：
    CSB-PA001692
  • 規(guī)格：
    ￥1090
  • 圖片：
    • Western Blot analysis of A549 cells using CLIP-115 Polyclonal Antibody
    • Western Blot analysis of NIH-3T3 LOVO cells using CLIP-115 Polyclonal Antibody
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    CLIP2
  • 別名：
    CAP GLY domain containing linker protein 2 antibody; CAP-Gly domain-containing linker protein 2 antibody; CLIP 115 antibody; CLIP antibody; CLIP-115 antibody; Clip2 antibody; CLIP2_HUMAN antibody; cytoplasmic linker 2 antibody; Cytoplasmic linker protein 115 antibody; Cytoplasmic linker protein 2 antibody; KIAA0291 antibody; MGC11333 antibody; restin antibody; Similar to RESTIN (CYTOPLASMIC LINKER PROTEIN 170 ALPHA 2) antibody; WBSCR3 antibody; WBSCR4 antibody; Williams Beuren syndrome chromosome region 3 antibody; Williams Beuren syndrome chromosome region 4 antibody; Williams-Beuren syndrome chromosomal region 3 protein antibody; Williams-Beuren syndrome chromosomal region 4 protein antibody; WSCR3 antibody; WSCR4 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthesized peptide derived from the C-terminal region of Human CLIP-115.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:5000
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Seems to link microtubules to dendritic lamellar body (DLB), a membranous organelle predominantly present in bulbous dendritic appendages of neurons linked by dendrodendritic gap junctions. May operate in the control of brain-specific organelle translocations.
  • 基因功能參考文獻(xiàn)：
    1. Cross checking with epidemiological estimates and model validation suggests that CLIP2 is a marker of high precision. CLIP2 leaves an imprint in the epidemiological incidence data which is typical for a driver gene. PMID: 27729373
    2. CLIP2 protein expression is elevated in papillary thyroid carcinomas from patients exposed to radioiodine fallout compared with a nonexposed control group. PMID: 25284583
    3. A clear radiation dose-response relationship for the CLIP2 marker expression in post-Chernobyl papillary thyroid carcinomas PMID: 25957251
    4. CLIP2 haploinsufficiency by itself does not lead to the physical or cognitive characteristics of the Williams-Beuren syndrome; GTF2IRD1 and GTF2I are the main genes causing the cognitive defects PMID: 22608712
    5. Data show that gene CLIP2 was specifically overexpressed in the exposed cases. PMID: 21606360

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  • 相關(guān)疾病：
    CLIP2 is located in the Williams-Beuren syndrome (WBS) critical region (PubMed:9799601). WBS results from a hemizygous deletion of several genes on chromosome 7q11.23, thought to arise as a consequence of unequal crossing over between highly homologous low-copy repeat sequences flanking the deleted region. Haploinsufficiency of CLIP2 may be the cause of certain cardiovascular and musculo-skeletal abnormalities observed in the disease. However, it has been demonstrated that haploinsufficiency of this gene alone is not sufficient to cause any of the cognitive or facial features of WBS (PubMed:22608712).
  • 亞細(xì)胞定位：
    Cytoplasm. Cytoplasm, cytoskeleton.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 2586

    OMIM: 603432

    KEGG: hsa:7461

    STRING: 9606.ENSP00000223398

    UniGene: Hs.647018



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