在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CLIC4 Antibody

CLIC4 Antibody

  • 中文名稱：
    CLIC4兔多克隆抗體
  • 貨號：
    CSB-PA969536
  • 規(guī)格：
    ￥1100
  • 圖片：
    • Gel: 12%SDS-PAGE,Lysate: 40 μg,Lane 1-2: Human normal kidney tissue, Human liver tissue,Primary antibody: CSB-PA969536(CLIC4 Antibody) at dilution 1/200 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 10 seconds
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    CLIC4
  • 別名：
    Chloride intracellular channel 4 antibody; Chloride intracellular channel 4 (mitochondrial) antibody; Chloride intracellular channel 4 like antibody; Chloride intracellular channel protein 4 antibody; Clic4 antibody; CLIC4_HUMAN antibody; CLIC4L antibody; DKFZP566G223 antibody; FLJ38640 antibody; H1 antibody; HUH1 antibody; Intracellular chloride ion channel protein p64H1 antibody; MC3S5 antibody; mtCLIC antibody; p64H1 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse,Rat
  • 免疫原：
    Synthetic peptide of Human CLIC4
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell-surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical-basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis).
  • 基因功能參考文獻：
    1. Results provide evidence that the G4 structure formed in the CLIC4 promoter region may act as a regulatory element in regulating CLIC4 gene transcription. PMID: 30201851
    2. CLIC4 and Ihh could serve as biological markers for the progression, metastasis and/or invasiveness of pancreatic ductal adenocarcinoma. PMID: 28205343
    3. in malignant pleural mesothelioma, the gene expressions of CLIC3 and CLIC4 were significantly increased compared to controls PMID: 26445368
    4. CLIC1 and CLIC4 are overexpressed in specific tumor types or their corresponding stroma and change localization and function from hydrophilic cytosolic to integral transmembrane proteins. (Review) PMID: 25546839
    5. CLIC4 knockdown decreases cell-matrix adhesion, cell spreading and integrin signaling, whereas it increases cell motility. PMID: 25344254
    6. This study investigated the proteome modulated by oncogenic KRAS in immortalized airway epithelial cells. PMID: 24503901
    7. Increased CLIC4 expression is an early manifestation and mediator of endothelial dysfunction in pulmonary hypertension. PMID: 24503951
    8. CLIC4 increases tumor cell migration and invasion in a TGF-beta-dependent manner. PMID: 23416981
    9. In addition to CLIC1 and TPM1, which were the proteins initially discovered in a xenograft mouse model, CLIC4, TPM2, TPM3, and TPM4 were present in ovarian cancer patient sera at significantly elevated levels compared with controls. PMID: 23792823
    10. Our data indicate that CLIC4 protein may be a key element in the apoptotic response to oxidative stress. PMID: 23380911
    11. These results demonstrate that CLIC4 nuclear translocation is an integral part of the cellular response to starvation. PMID: 22761775
    12. Reduced CLIC4 expression and nuclear residence detected in cancer cells is associated with the altered redox state of tumor cells and the absence of detectable nuclear CLIC4 in cancers contributes to TGF-beta resistance and enhances tumor development. PMID: 22387366
    13. CLIC4 may not be responsible for benign familial infantile seizures (BFIS) in a Chinese family affected with BFIS. PMID: 20374090
    14. Data suggest that CLIC4 is regulated by RhoA to be targeted to the plasma membrane, where it may function not as an inducible chloride channel but rather by displaying Cys-dependent transferase activity toward a yet unknown substrate. PMID: 19776349
    15. CLIC4 functions to promote endothelial cell proliferation and to regulate endothelial morphogenesis, and is thus involved in multiple steps of in vitro angiogenesis. PMID: 19247789
    16. CLIC4 is differentially regulated in fibroblasts and its expression contributes to a myofibroblast phenotype PMID: 12163372
    17. CLIC4 has alternate cellular functions that are distinct from their proposed roles as chloride channels PMID: 14569596
    18. subcellular localization of CLIC4 in endothelial cells was dependent on whether cells were engaged in proliferation or tube formation PMID: 16239224
    19. up-regulation of mitochondrial CLIC4, together with a reduction in Bcl-2 and Bcl-xL, sensitizes Myc-expressing cells to the proapoptotic action of Bax. PMID: 16316993
    20. preliminary crystallographic analysis PMID: 16842122
    21. CLIC4 in tumor stroma has a role in myofibroblast conversion in human neoplasms PMID: 17200346
    22. Nuclear CLIC4, possibly by altering the Cl(-) and pH of the nucleus, contributes to cell cycle arrest and the specific gene expression program associated with keratinocyte terminal differentiation. PMID: 17636002
    23. Data showed that CLIC1 and CLIC5, but not CLIC4, were strongly and reversibly inhibited (or inactivated) by F-actin. PMID: 18028448
    24. ROS-initiated CLIC4 up-regulation is required for TGF-beta1-induced fibroblast-to-myofibroblast transdifferentiaton in ovarian cancer. PMID: 19639201
    25. S100A4 and bone morphogenetic protein-2 codependently induce vascular smooth muscle cell migration via phospho-extracellular signal-regulated kinase and chloride intracellular channel 4. PMID: 19713532

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane; Single-pass membrane protein. Nucleus matrix. Cell membrane; Single-pass membrane protein. Mitochondrion. Cell junction. Note=Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles.
  • 蛋白家族：
    Chloride channel CLIC family
  • 組織特異性：
    Detected in epithelial cells from colon, esophagus and kidney (at protein level). Expression is prominent in heart, kidney, placenta and skeletal muscle.
  • 數(shù)據庫鏈接：

    HGNC: 13518

    OMIM: 606536

    KEGG: hsa:25932

    STRING: 9606.ENSP00000363500

    UniGene: Hs.440544



主站蜘蛛池模板： 无码人妻aⅴ一区二区三区69岛| 亚洲偷自拍国综合色帝国| 国产乱子伦农村叉叉叉| 国产福利日本一区二区三区| 国产午夜人做人免费视频网站| 欧美真人性做爰全过程| 国产精品情侣呻吟对白视频| 在线观看日本亚洲一区| 成人无码精品免费视频在线观看| 亚洲国产精品隔壁老王 | 国产成人拍精品视频午夜网站| 日本精品少妇一区二区三区| 99久久婷婷国产综合精品| 国产成人无码牲交免费视频| 国产一区二区不卡在线看| 亚洲一区二区三区中文字幕在线| 亚洲国产精品一区二区成人片| 国产精品一区二区久久| 免费人成视频在线观看不卡| 国产福利酱国产一区二区| 国产狂喷潮在线观看| 久久天天躁夜夜躁狠狠85麻豆| 精品成人免费一区二区不卡| 久久综合少妇11p| 国产成人午夜福利电影在线播放| 国产成人精品亚洲777人妖| 亚洲国产无线乱码在线观看| 97精品久久天干天天| 99久久99视频只有精品| 精品人人妻人人澡人人爽牛牛| 国精品无码一区二区三区在线| 成 人 亚洲 综合天堂| 国产精品欧美久久久久无广告| 色88久久久久高潮综合影院| 粗大猛烈进出高潮视频免费看 | 丰满少妇夜夜爽爽高潮水| 天天天天躁天天爱天天碰2018 | 亚洲国产专区校园欧美| 亚洲午夜av久久久精品影院色戒 | 久久久久国色av免费观看| 窝窝午夜理论片影院|