在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CLEC4A Antibody

CLEC4A Antibody

  • 中文名稱：
    CLEC4A兔多克隆抗體
  • 貨號：
    CSB-PA181586
  • 規格：
    ￥1100
  • 圖片：
    • Gel: 10%SDS-PAGE,Lysate: 40 μg,,Primary antibody: CSB-PA181586(CLEC4A Antibody) at dilution 1/100 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    C type (calcium dependent carbohydrate recognition domain) lectin superfamily member 6 antibody; C type lectin antibody; C type lectin DDB27 antibody; C type lectin superfamily 6 antibody; C-type (calcium dependent; carbohydrate-recognition domain) lectin; superfamily member 6 antibody; C-type lectin superfamily member 6 antibody; C-type lectin DDB27 antibody; C-type lectin domain family 4 member A antibody; C-type lectin domain family 4; member A antibody; C-type lectin domain family 4; member a2 antibody; C-type lectin superfamily member 6 antibody; CLC4A_HUMAN antibody; Clec4a antibody; Clec4a2 antibody; CLECSF6 antibody; DCIR antibody; Dcir1 antibody; DDB27 antibody; Dendritic cell immunoreceptor antibody; HDCGC13P antibody; Lectin like immunoreceptor antibody; Lectin; C-type; superfamily member 6 antibody; Lectin-like immunoreceptor antibody; LLIR antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Mouse
  • 免疫原：
    Fusion protein of Human CLEC4A
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,WB
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    WB 1:500-1:2000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    C-type lectin receptor that binds carbohydrates mannose and fucose but also weakly interacts with N-acetylglucosamine (GlcNAc) in a Ca(2+)-dependent manner. Involved in regulating immune reactivity. Once triggered by antigen, it is internalized by clathrin-dependent endocytosis and delivers its antigenic cargo into the antigen presentation pathway resulting in cross-priming of CD8(+) T cells. This cross-presentation and cross-priming are enhanced by TLR7 and TLR8 agonists with increased expansion of the CD8(+) T cells, high production of IFNG and TNF with reduced levels of IL4, IL5 and IL13. In plasmacytoid dendritic cells, inhibits TLR9-mediated IFNA and TNF production. May be involved via its ITIM motif (immunoreceptor tyrosine-based inhibitory motifs) in the inhibition of B-cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation.; (Microbial infection) Involved in the interaction between HIV-1 virus and dendritic cells. Enhances HIV-1 binding/entry and virus infection. Requires ITIM motif-associated signal transduction pathway involving phosphatases PTPN6 and PTPN11, SYK, Src kinases and MAP kinases.
  • 基因功能參考文獻：
    1. Authors have determined the structure, tissue distribution, and molecular function of the cartilage-specific lectin CLEC3A and show that CLEC3A binds to plasminogen and participates in tPA-mediated plasminogen activation. PMID: 29146595
    2. DCIR SNP rs2377422 is a novel genetic susceptibility factor for both SLE and primary SS. PMID: 26429306
    3. this study shows that sulfo-Lewis(a) is a high affinity ligand for DCIR and that DCIR interacts with ligands from both pathogenic and endogenous origin of which most are shared by DC-SIGN. PMID: 24239607
    4. No association was found between our inflammatory bowel disease cohort and the candidate single nucleotide polymorphisms for DCIR (CD/HC: P=0.22 and UC/HC: P=0.41) PMID: 22664939
    5. Data provide evidence for association between DCIR rs2377422 and RA in non-Caucasian populations and confirm the influence of DCIR polymorphisms on RA susceptibility, especially on ACPA-negative RA. PMID: 22829930
    6. An involvement of ITIM domain in HIV-1-mediated signaling events and a relationship between phosphorylation events and DCIR function with respect to HIV-1 biology. PMID: 21536857
    7. Data show that antigen targeting via the DCIR receptor allows activation of specific CD8(+) T-cell immunity. PMID: 20530286
    8. CLECSF6 is involved in the control of inflammation in neutrophils PMID: 14550269
    9. The phosphorylation of SHP-2 by GM-CSF promotes the binding of SHP-2 to the GM-CSF receptor to the disadvantage of CLECSF6. PMID: 16360206
    10. Human APLEC and DCIR may be associated with susceptibility to anti-CCP-negative rheumatoid arthritis. PMID: 17665455
    11. The data show that targeting of DCIR can modulate human plasmacytoid dendritic cell function and may be applied in disease prevention and treatment. PMID: 18258799
    12. The mRNA expression from the four known transcripts of DCIR in IFN-gamma-treated human leukocytes together with fine mapping across the locus was analyzed. PMID: 18480830
    13. can participate in the capture of HIV-1 and promote infection in trans and in cis of autologous CD4(+) T cells from human immature monocyte-derived DCs. PMID: 18541725
    14. DCIR as an antigen presenting cell receptor that is endocytosed efficiently in a clathrin-dependent manner and negatively affects TLR8-mediated cytokine production. PMID: 19028959

    顯示更多

    收起更多

  • 亞細胞定位：
    Cell membrane; Single-pass type II membrane protein; Extracellular side.
  • 組織特異性：
    Expressed preferentially in hematopoietic tissues. Expressed in all circulating Ag-presenting cells such as dendritic cells, myeloid cells, monocytes, macrophages, B-cells and epidermal Langerhans cells (at protein level). Expressed in peripheral blood le
  • 數據庫鏈接：

    HGNC: 13257

    OMIM: 605306

    KEGG: hsa:50856

    STRING: 9606.ENSP00000229332

    UniGene: Hs.504657



主站蜘蛛池模板： 色婷婷亚洲一区二区综合| 亚洲中文字幕无码中文| 精品一卡2卡3卡4卡新区在线| 国产良妇出轨视频在线观看| 45分钟免费真人视频| 女女同性av片在线观看免费| 四虎国产精品永久在线无码| 日韩av片无码一区二区不卡电影| 亚洲精品一区二区三区在线| 国产亚洲日本精品成人专区 | 国产三级aⅴ在在线观看| 久久亚洲精品中文字幕无码| 国产尤物精品视频| 久久精品免视看国产成人| 欧美老肥妇多毛xxxxx| 风流少妇又紧又爽又丰满| 欧美性猛交xxxx免费看| 精品国产av最大网站| 欧美日韩无线码在线观看| 色135综合网| 国产国语毛片在线看国产| 中文字字幕乱码视频高清| 曰韩无码二三区中文字幕| 99久久人妻精品免费二区| av一区二区三区人妻少妇| 中文字幕制服丝袜第57页| 中文亚洲欧美日韩无线码 | 久久久噜噜噜久久熟女aa片| 久久综合给合久久狠狠97色| 无码h黄肉3d动漫在线观看| 欧美熟妇的性裸交| 伊人久久大香线蕉aⅴ色| 超碰97久久国产精品牛牛| 国内精品国产三级国产av| 亚洲乱码卡一卡二卡新区中国| 国产jk白丝在线观看免费 | 四虎www成人影院观看| 人妻无码久久久久久久久久久| 思思99re6国产在线播放| 午夜免费啪视频观看视频| 久久久久国色av免费看|