在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CLEC12A Antibody

CLEC12A Antibody

  • 中文名稱：
    CLEC12A兔多克隆抗體
  • 貨號：
    CSB-PA725176ESR1HU
  • 規(guī)格：
    ￥440
  • 圖片：
    • Western blot
      All lanes: C-type lectin domain family 12 member A antibody at 2μg/ml + Mouse skeletal muscle tissue
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 31, 33, 9, 28, 25 kDa
      Observed band size: 31 kDa
    • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA725176ESR1HU at dilution of 1:100
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品描述：

    The CLEC12A antibody was raised in rabbits against a partial recombinant protein corresponding to the 66-265 amino acids of the human CLEC12A protein. It exists as an unconjugated IgG isoform. It underwent antigen affinity purification.

    This CLEC12A polyclonal antibody has undergone rigorous quality control in multiple applications, including ELISA, WB, and IHC. And it shows reactivity with human and mouse CLEC12A protein. The CLEC12A protein mainly modulates the immune response, particularly in the regulation of myeloid cell activation and differentiation. It is also involved in the pathogenesis of certain cancers and autoimmune diseases.

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CLEC12A Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    C-type lectin domain family 12 member A antibody; C-type lectin-like molecule 1 antibody; CL12A_HUMAN antibody; CLEC12A antibody; CLL-1 antibody; DCAL-2 antibody; Dendritic cell-associated lectin 2 antibody; MICL antibody; Myeloid inhibitory C-type lectin-like receptor antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human, Mouse
  • 免疫原：
    Recombinant Human C-type lectin domain family 12 member A protein (66-265AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA, WB, IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    IHC 1:20-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能：
    Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.
  • 基因功能參考文獻(xiàn)：
    1. Enumeration of circulating hMICL+ stem cells by flow cytometry can discriminate between myeloproliferative neoplasm phenotypes and holds potential for monitoring disease evolution. PMID: 29427319
    2. CLL-1 is a novel prognostic predictor that could be exploited to supplement the current acute myeloid leukemia prognostic risk stratification system. PMID: 28810819
    3. The CLEC12A is an effective new candidate with great potential for in vivo Ag delivery into mDCs and pDCs, thereby using the specialized functions and cross-talk capacity of these DC subsets to boost tumor-reactive T cell immunity in cancer patients. PMID: 27566820
    4. Due to the absence of CLEC12A on normal haematopoietic stem cells, CLEC12A stem cell immunophenotyping may contribute to diagnosing and monitoring MDS patients and could furthermore add knowledge about disease propagating cells in MDS. PMID: 27612176
    5. We propose the hypothesis that decreased expression of CLEC12A is a common denominator in the hyperinflammatory responses observed in Behcet's syndrome and gout. PMID: 25957656
    6. Upon CLL1-selective binding of this fusion protein, granulocytes acquire additional TRAIL-mediated cytotoxic activity that, importantly, potentiates antibody-mediated cytotoxicity of clinically used therapeutic antibodies PMID: 25760768
    7. We conclude the hMICL/CD123-based MFC assay is a promising MRD tool in AML. PMID: 24152218
    8. There is a potential genetic association of CLEC12A with rheumatoid arthritis (RA). Since CLEC12A encodes for the myeloid inhibitory C-type lectin-like receptor that modulates cytokine synthesis, this receptor may contribute to the pathogenesis of RA. PMID: 22341585
    9. For production of cytotoxic T cells, transgenic DEC-205 and Clec9A, but not Clec12A, are effective targets for antibody-mediated delivery of antigens for vaccination, although only in the presence of adjuvants. PMID: 21677141
    10. MICL is a negative regulator of granulocyte and monocyte function PMID: 14739280
    11. the molecular cloning, tissue distribution, and functional characterization of a novel NK cell receptor, KLRL1, from human and mouse dendritic cells [KLRL1] PMID: 15238421
    12. Expression cloning identified the antigen recognized as C-type lectin-like molecule-1, a previously undescribed transmembrane glycoprotein PMID: 15548716
    13. Dendritic-cell (DC)-associated C-type lectin receptors (CLRs) take up antigens to present to T cells and regulate DC functions. PMID: 16239426
    14. human MICL may be involved in the control of myeloid cell activation during inflammation PMID: 16838277
    15. CLL-1 expression is also present on the CD34(+)CD38(-) stem- cell compartment in acute myeloid leukemia PMID: 17609428
    16. mMICL recognises an endogenous ligand in a variety of murine tissues, suggesting that the receptor plays a role in homeostasis PMID: 18350551
    17. Anti-Clec12A mAb alone produced only moderate responses, but these were amplified by coinjecting only small amounts of LPS as a dendritic cell activation agent PMID: 19494282

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Cell membrane; Single-pass type II membrane protein. Note=Ligand binding leads to internalization.
  • 組織特異性：
    Detected in normal myeloid cells and in acute myeloid leukemia cells. Detected in neutrophils, eosinophils, monocytes and dendritic cells. Detected in spleen macrophage-rich red pulp and in lymph node (at protein level). Detected in peripheral blood leuko
  • 數(shù)據(jù)庫鏈接：

    HGNC: 31713

    OMIM: 612088

    KEGG: hsa:160364

    STRING: 9606.ENSP00000347916

    UniGene: Hs.190519



主站蜘蛛池模板： 亚洲国产成人无码av在线| 日本一卡二卡不卡视频查询| 高h纯肉无码视频在线观看| 东方aⅴ免费观看久久av| 看黄a大片爽爽影院免费无码 | 欧洲极品无码一区二区三区| 十八禁午夜福利免费网站| 五 月 丁 香 综合中文| 亚洲性夜色噜噜噜网站2258kk| 国产精品99久久精品爆乳| 精品无码一区二区三区电影| 狠狠色综合久久丁香婷婷| 久久国产午夜精品理论片34页| 亚洲人成未满十八禁网站| 欧美性猛交ⅹxxx乱大交妖精| 美女裸体跪姿扒开屁股无内裤 | 新香蕉少妇视频网站| 亚洲自偷自拍熟女另类| 午夜无码片在线观看影院| 久久亚洲中文字幕伊人久久大| 国内精品伊人久久久久妇| 亚洲中久无码永久在线观看同| 国产成人久久av免费高潮| 色悠久久久久综合网香蕉| 女人的天堂a国产在线观看| 秋霞午夜一区二区三区黄瓜视频| 精品国产亚洲一区二区三区| 亚洲国产成人av在线观看| 国产精品无打码在线播放| 免费无遮挡在线观看网站| 久久亚洲精品无码va白人极品| 加勒比一本heyzo高清视频| 国产成人a区在线观看| ww欧日韩视频高清在线| 色诱久久久久综合网ywww| 欧美丰满熟妇xxxx性大屁股| 人妻少妇av无码一区二区| 人禽交 欧美 网站| 女人夜夜春精品a片| 日韩毛片在线视频x| 日韩精品人妻无码久久影院|