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CLEC11A Antibody

  • 中文名稱:
    CLEC11A兔多克隆抗體
  • 貨號:
    CSB-PA896480ESR2HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA896480ESR2HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA896480ESR2HU at dilution of 1:100
    • Immunofluorescent analysis of HepG2 cells using CSB-PA896480ESR2HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CLEC11A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CLEC11A
  • 別名:
    C type (calcium dependent; carbohydrate recognition domain) lectin; superfamily member 3 antibody; C type lectin domain family 11 member A antibody; C type lectin superfamily member 3 antibody; C-type lectin domain family 11 member A antibody; C-type lectin superfamily member 3 antibody; CLC11_HUMAN antibody; CLEC11A antibody; CLECSF3 antibody; LSLCL antibody; Lymphocyte secreted C type lectin antibody; Lymphocyte secreted C-type lectin antibody; lymphocyte secreted long form of C type lectin antibody; p47 antibody; Stem cell growth factor antibody; stem cell growth factor lymphocyte secreted C type lectin antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human C-type lectin domain family 11 member A protein (22-323AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC, IF
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
    IF 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Promotes osteogenesis by stimulating the differentiation of mesenchymal progenitors into mature osteoblasts. Important for repair and maintenance of adult bone.
  • 基因功能參考文獻:
    1. Clec11a maintains the adult skeleton by promoting the differentiation of mesenchymal progenitors into mature osteoblasts. PMID: 27976999
    2. Data show that asymptomatic patients with unstable plaques exhibited higher levels of endothelial microparticles (EMPs), CXCL9 chemokine and stem cell growth factor; lymphocyte secreted C-type lectin (SCGF-beta) compared to those with stable plaques. PMID: 26564003
    3. level of expression correlates with pain response in subjects with intervertebral disc disorders PMID: 26440592
    4. This is the first report of SCGF beta in heart failure patients. PMID: 23357302
    5. These studies highlight a possible role of SCGFalpha in imatinib-induced changes of gastrointestinal stromal tumors structure, consistent with a therapeutic response. PMID: 21943129
    6. The results presented here demonstrate that homozygous T at -539 in the SCGF promoter is associated with elevated SCGF production, enhanced erythropoiesis, and protection against severe malarial anemia. PMID: 19884328
    7. SCGF is selectively produced by osseous and hematopoietic stromal cells, and can mediate their proliferative activity on primitive hematopoietic progenitor cells. PMID: 11920266
    8. Results indicate that interleukin-4, together with recombinant human stem cell factor, can induce T cell maturation from cord blood progenitor cells, and that IL-4 increased the expression of FcepsilonRI on fetal liver mast cells. PMID: 14746805
    9. Human vascular smooth muscle cells express stem cell factor(SCF) and its receptor, c-kit. SCF is released from its membrane-bound form via MMP-9. SCF/c-kit signaling may affect SMC function via an autocrine pathway. PMID: 15234225
    10. phagocytosis of hemozoin promotes a decrease in SCGF gene products, which may contribute to reduced erythropoiesis in children with severe malarial anemia. PMID: 19528216

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  • 亞細胞定位:
    Cytoplasm. Secreted.
  • 組織特異性:
    Expressed in skeletal tissues including bone marrow, chondrocytes, primary ossification center-associated cells, the perichondrium and periosteum. Lower levels of expression were detected in spleen, thymus, appendix and fetal liver.
  • 數據庫鏈接:

    HGNC: 10576

    OMIM: 604713

    KEGG: hsa:6320

    STRING: 9606.ENSP00000250340

    UniGene: Hs.512680



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