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CLDN14 Antibody

  • 中文名稱:
    CLDN14兔多克隆抗體
  • 貨號:
    CSB-PA005494ESR1HU
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: Claudin-14 antibody at 4μg/ml
      Lane 1: Rat liver tissue
      Lane 2: Mouse kidney tissue
      Lane 3: Hela whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 26 kDa
      Observed band size: 26 kDa
    • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA005494ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA005494ESR1HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品描述:

    The polyclonal CLDN14 antibody is raised in rabbits against the recombinant human CLDN14 protein (140-239AA). It occurs as an unconjugated IgG. It underwent antigen affinity purified. And it shows reactivity with CLDN14 of human-, mouse-, and rat-origin. The target protein CLDN14 is important for the physiology of cochlear hair cells in the inner ear. Studies found that dysregulation of the renal CaSR-CLDN14 pathway could contribute significantly to the development of hypercalciuria, and hence the generation of kidney stones and osteoporosis. This anti-CLDN14 antibody can be used to recognize the CLDN14 protein in ELISA, WB, and IHC applications.

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CLDN14 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CLDN14
  • 別名:
    CLDN14; UNQ777/PRO1571; Claudin-14
  • 宿主:
    Rabbit
  • 反應種屬:
    Human, Mouse, Rat
  • 免疫原:
    Recombinant Human Claudin-14 protein (140-239AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:200-1:1000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.
  • 基因功能參考文獻:
    1. This study suggested considerable genetic heterogeneity in the causation of hearing loss in Dhadkai. Recessive mutations were observed in at least three genes causing hearing loss: OTOF (p.R708X), SLC26A4 (p.Y556X) and CLDN14 (p.V85D). Mutation p.R708X appeared to be the major cause of hearing impairment in Dhadkai. PMID: 29434063
    2. CLDN14 might not be a major causative gene for NSHL in Chinese populations, which would contribute to fully understanding the genetic cause of NSHL in the East Asian populations PMID: 29447821
    3. Our data suggest that children with the INSM1 binding site within the CLDN14 risk haplotype have a higher likelihood of hypercalciuria and kidney stones. Enhanced CLDN14 expression may play a role in the pathophysiology of their hypercalciuria. PMID: 28229505
    4. All hearing impaired individuals, including the proband, are homozygous for a pathogenic variant of CLDN14, but this only explains the deafness. PMID: 27629923
    5. Extensive clinical recruitment and targeted screening suggest that CLDN14 p.(Ala163Val) represents a major founder variant for prelingual sensorineural hearing loss in the Newfoundland population. PMID: 27838790
    6. CLDN14 is a novel direct target of EZH2-mediated H3K27ME3 and plays role in EZH2-H3K27ME3-mediated hepatocellular carcinoma aggressiveness. PMID: 27207647
    7. The rs170183 was correlated with a decline in claudin 14 expression in both lymphoblastoid cell lines and T cells. PMID: 26842849
    8. Rs1801725 (Ala986-Ser), rs1042636 (Arg990Gly) of CaSR gene and rs219778, rs219780 (Thr229Thr) of CLDN14 gene were significantly associated with kidney stone disease in patients from the Eastern part of India. PMID: 26107257
    9. Claudin 14 expression was up-regulated in gastric cancer. PMID: 24325792
    10. Data suggest a possible role for Claudin14 in urinary calcium excretion. PMID: 23991001
    11. CLDN14 mutations can contribute to the aetiology of childhood/congenital deafness in Moroccan patients. PMID: 23590985
    12. Human Cldn-8 and -14 were shown to convey Clostridium perfringens enterotoxin-mediated cytotoxicity at pathophysiologically relevant concentrations of this toxin, although ~2-to-10-fold less efficiently than Cldn-4. PMID: 23322640
    13. OPRM1 genetic polymorphisms are associated with the plasma concentration of cotinine in a Taiwanese MMT cohort. Carriers with the major allele of SNP rs1799971 had a higher plasma cotinine concentration. PMID: 23235333
    14. The hearing loss due to novel CLDN14 mutations is prelingual, severe-to-profound with greater loss in the high frequencies. PMID: 22246673
    15. The CLDN14 promoter is activated by Trichostatin A (TSA) treatment according to promoter reporter assays in HEK 293 cells. PMID: 20494980
    16. Individuals with mutations of CLDN14 may have different degrees of hearing loss and the loss is greater at higher frequencies. PMID: 20811388
    17. The palmitoylation of claudin-14 is required for efficient localization into tight junctions but not stability or strand assembly. PMID: 15769849
    18. The ability of CLDN14 to be recruited to these junctions is crucial for the hearing process. PMID: 15880785
    19. Common, synonymous variants in the CLDN14 gene that associate with kidney stones, were discovered. PMID: 19561606

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  • 相關疾病:
    Deafness, autosomal recessive, 29 (DFNB29)
  • 亞細胞定位:
    Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Claudin family
  • 組織特異性:
    Liver, kidney. Also found in ear.
  • 數據庫鏈接:

    HGNC: 2035

    OMIM: 605608

    KEGG: hsa:23562

    STRING: 9606.ENSP00000339292

    UniGene: Hs.660278



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