在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CLDN10 Antibody

CLDN10 Antibody

  • 中文名稱：
    CLDN10兔多克隆抗體
  • 貨號：
    CSB-PA228012
  • 規格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA228012(CLDN10 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA228012(CLDN10 Antibody) at dilution 1/50, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
    CLDN10
  • 別名：
    CLDN10; Claudin-10; Oligodendrocyte-specific protein-like; OSP-like
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Synthetic peptide of Human CLDN10
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:10000
    IHC 1:50-1:200
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity. Involved in the regulation of paracellular epithelia permeability to ions in multiple organs. It acts as a paracellular ion channel probably forming permselective pores; isoform 1 appears to create pores preferentially permeable to cations and isoform 2 for anions. In sweat glands and in the thick ascending limb (TAL) of Henle's loop in kidney, it controls paracellular sodium permeability which is essential for proper sweat production and renal function.
  • 基因功能參考文獻：
    1. The CLDN10 polymorphism of rs1325774 was significantly associated with an increased risk of breast cancer. After adjusting for age, the association remained statically significant. Furthermore, harbouring G allele in rs1325774 position was significantly associated with increased risk of breast cancer. However, no significant association among rs7333503, rs3751334, and breast cancer. PMID: 30544377
    2. These renal-derived features recapitulate several phenotypic aspects detected in mice with kidney specific loss of both claudin-10 isoforms. Our study adds to the spectrum of phenotypes caused by tight junction proteins and demonstrates a pivotal role for claudin-10b in maintaining paracellular Na+ permeability for sweat production and kidney function. PMID: 28686597
    3. localization of Cldn3, Cldn7 and Cldn10 proteins in the different compartments of murine endometrium up to day 8.5 of pregnancy (dpc) as well as in human endometrium and first trimester decidua PMID: 26340953
    4. Expression of CLDN1 and CLDN10 was lower in invasive lepidic predominant adenocarcinoma than in lung adenocarcioma in situ. Overexpression of CLDN1 and CLDN10 indicates a favorable prognosis in some patients with lung adenocarcinoma. PMID: 23591077
    5. Claudin 10 expression was down-regulated in gastric cancer. PMID: 24325792
    6. In claudin-10b, the F66L mutant reduced cation selectivity, and the F66A mutant lost pore conductance PMID: 23760508
    7. Claudin 10/18 are most commonly expressed in lung adenocarcinomas. Female patients and non-smokers express these claudins more commonly suggesting that they may play a part in the carcinogenesis of tobacco unrelated carcinoma. PMID: 22076167
    8. Claudin 10 protein is highly expressed in hepatocellular carcinoma (HCC) tissue and is closely related to angiogenesis. It could be a useful marker to predict poor prognosis of HCC patients after hepatectomy. PMID: 21647678
    9. CLDN10 is a novel biomarker for detecting ovarian cancer in the chicken, a suitable animal model for investigating the effect and function of CLDN in human ovarian cancer. PMID: 21370593
    10. High Claudin-10 expression level is associated with recurrence of primary hepatocellular carcinoma PMID: 15701840
    11. These findings showed that CLDN-10 is functionally involved in hepatocellular carcinoma invasion and is a potential target for hepatocellular carcinoma therapy. PMID: 18025272
    12. Claudin-10 exists in six alternatively spliced isoforms that exhibit distinct localization and function. PMID: 19383724

    顯示更多

    收起更多

  • 相關疾病：
    HELIX syndrome (HELIX)
  • 亞細胞定位：
    Cell junction, tight junction. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Claudin family
  • 組織特異性：
    Expressed in the kidney, eccrine sweat glands and in all layers of the epidermis. In the kidney, it is detected in the thick ascending limb of Henle's loop (TAL). In the sweat glands, it is expressed in cells from secretory portions, corresponding to the
  • 數據庫鏈接：

    HGNC: 2033

    OMIM: 617579

    KEGG: hsa:9071

    STRING: 9606.ENSP00000299339

    UniGene: Hs.534377



主站蜘蛛池模板： 欧美乱大交xxxxx疯狂俱乐部| 婷婷综合久久中文字幕| 久久久精品2019免费观看| 国产最新进精品视频| 噜噜久久噜噜久久鬼88| 精品国内综合一区二区| www国产精品内射| 亚洲多毛妓女毛茸茸的| 国产一区二区三区不卡在线看| 亚洲va中文字幕无码久久 | 少妇无套内谢久久久久| 一本加勒比波多野结衣| 久久综合给久久狠狠97色| 韩国无码av片在线观看| 午夜寂寞少妇aaa片毛片| 国产内射老熟女aaaa| 五十路熟妇强烈无码| 日日做夜狠狠爱欧美黑人| 蜜桃av抽搐高潮一区二区 | 欧美片内射欧美美美妇| 亚洲国产精品国自产拍av| 免费无码又爽又刺激高潮的视频| 欧美成人精品第一区| 国产精品高潮呻吟av久久小说| 久久精品国产99国产精偷| 97久久精品人人澡人人爽| 婷婷综合缴情亚洲狠狠小说| 国产亚洲欧美日韩精品一区二区 | 欧美日韩精品一区二区在线观看| 日韩av无码中文无码电影| 无码少妇精品一区二区免费| 国产玉足榨精视频在线观看 | 久久人妻av一区二区软件| 成人午夜福利视频后入| 精品国产午夜福利在线观看| 国产成人精品永久免费视频| 无码人妻精品一区二| 特级毛片爽www免费版| 精品欧美一区二区三区久久久 | 天堂俺去俺来也www色官网| 久久人人爽人人爽人人片av高请 |