在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CLASP2 Antibody

  • 中文名稱:
    CLASP2兔多克隆抗體
  • 貨號(hào):
    CSB-PA005472GA01HU
  • 規(guī)格:
    ¥3,900
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    CLASP2
  • 別名:
    CLASP2; KIAA0627; CLIP-associating protein 2; Cytoplasmic linker-associated protein 2; Protein Orbit homolog 2; hOrbit2
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human CLASP2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules. Involved in the nucleation of noncentrosomal microtubules originating from the trans-Golgi network (TGN). Required for the polarization of the cytoplasmic microtubule arrays in migrating cells towards the leading edge of the cell. May act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2. This cortical microtubule stabilizing activity is regulated at least in part by phosphatidylinositol 3-kinase signaling. Also performs a similar stabilizing function at the kinetochore which is essential for the bipolar alignment of chromosomes on the mitotic spindle. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex.
  • 基因功能參考文獻(xiàn):
    1. CLASP2 is involved in the epithelial-mesenchymal transition and progression of bladder urothelial cancer. Simultaneous urine-based detection of CLASP2 and E-cadherin mRNA can efficiently discriminate patients with or without 2-years progression after transurethral resection of the bladder tumor. PMID: 28166762
    2. These findings reveal a new role for Clasp2 in governing keratinocyte undifferentiated features. PMID: 28069833
    3. Prickle1 localized to the membrane through its farnesyl moiety, and the membrane localization was necessary for Prickle1 to regulate migration, to bind to CLASPs and LL5beta, and to promote microtubule targeting of focal adhesions. PMID: 27378169
    4. this study shows that GSK3-mediated phosphorylation of CLASP2alpha largely abolishes CLASP2alpha-microtubule association in metaphase thus contributing to correct chromosome dynamics PMID: 28232523
    5. PAR3 and aPKC control the organization of the Golgi through CLASP2 phosphorylation. PMID: 25518939
    6. GSK3B-dependent phosphorylation and the level of CLASP2 play a role in the maintenance of acetylcholine receptor cluster size through the regulated capture and release of microtubule plus-ends. PMID: 25231989
    7. Propose that CLASPs couple microtubule organization, vesicle transport and cell interactions with the ECM, establishing a local secretion pathway that facilitates focal adhesion turnover by severing cell-matrix connections. PMID: 24859005
    8. Results suggest a previously unidentified role for the scaffolding protein 4.1R in locally controlling CLASP2 behavior, CLASP2 cortical platform turnover and GSK3 activity, enabling correct MT organization and dynamics essential for cell polarity. PMID: 23943871
    9. The epiblast epithelial status was maintained by anchoring microtubules to the basal cortex via CLIP2, a microtubule plus-end tracking protein, and Dystroglycan, a transmembrane protein that bridges the cytoskeleton and basement membrane (BM). PMID: 23940118
    10. Overexpression of human CLASP2 in mouse neurons caused the formation of multiple axons, enhanced dendritic branching, & Golgi condensation. These morphogenetic changes led to significant functional alterations in synaptic transmission. PMID: 23035100
    11. propose that Cdk1 and Plk1 mediate a fine CLASP2 "phospho-switch" that temporally regulates kinetochore-microtubule attachment stability PMID: 23045552
    12. Data show that CENP-E-mediated traction forces on misaligned chromosomes are responsible for the irreversible loss of spindle-pole integrity in CLASP1/2-depleted cells. PMID: 22307330
    13. Regulation of microtubule dynamics by TOG-domain proteins XMAP215/Dis1 and CLASP PMID: 21782439
    14. Data report that NEK1 and CLASP2 colocalize with FEZ1 in a perinuclear region in mammalian cells, and observed that coiled-coil interactions occur between FEZ1/CLASP2 and FEZ1/NEK1 in vitro. PMID: 19924516
    15. propose that CLASP1 and CLASP2 can mediate interactions between microtubule plus ends and the cell cortex and act as local rescue factors, possibly through forming a complex with EB1 at microtubule tips PMID: 15631994
    16. These results demonstrate the striking difference of the microtubule cytoskeleton in the lamella as compared with the cell body and provide the first direct observation of subcellular regulation of a microtubule-associated protein in migrating cells. PMID: 15955847
    17. CLASPs provide apparent stabilization of microtubules by locally reducing the amplitude of growth/shortening episodes at the microtubule ends. PMID: 16866869
    18. Together, our data support that the partial redundancy of CLASPs during mitosis acts as a possible mechanism to prevent aneuploidy in mammals. PMID: 16914514
    19. GSK3beta phosphorylation modulates CLASP-microtubule association and lamella microtubule attachment. PMID: 19289791
    20. A role for microtubules that form at the Golgi membranes is identified in a manner dependent on the microtubule regulators CLASPs. PMID: 19701196

    顯示更多

    收起更多

  • 亞細(xì)胞定位:
    Cytoplasm, cytoskeleton. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Chromosome, centromere, kinetochore. Cytoplasm, cytoskeleton, spindle. Golgi apparatus. Golgi apparatus, trans-Golgi network. Cell membrane. Cell projection, ruffle membrane.
  • 蛋白家族:
    CLASP family
  • 組織特異性:
    Brain-specific.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 17078

    OMIM: 605853

    KEGG: hsa:23122

    STRING: 9606.ENSP00000419974

    UniGene: Hs.108614



主站蜘蛛池模板: av鲁丝一区鲁丝二区鲁丝三区| 无遮无挡爽爽免费视频| 久久久久久九九精品久| av人摸人人人澡人人超碰下载| 狠狠躁夜夜躁av网站中文字幕| 少妇性l交大片7724com| 2021最新精品国自产拍视频| 欧美 亚洲 日韩 中文2019| 中文无码乱人伦中文视频在线| 中文字幕av在线一二三区| 老湿机国产福利视频| 色琪琪av中文字幕一区二区| 女人扒开屁股桶爽30分钟| 伊人蕉久中文字幕无码专区| 成人区人妻精品一区二区不卡视频| 久久人人97超碰国产亚洲人| 久久人妻国产精品31| √天堂8资源中文在线| 亚洲精品国产品国语在线观看| 亚洲一区波多野结衣在线| 少妇无码av无码去区钱| 久久不见久久见免费影院3| 国产av无码专区亚洲精品| 久久人人爽av亚洲精品| 国产精品高清网站| 中文字幕在线亚洲精品| 欧美兽交xxxx×视频| 2020精品国产自在现线官网 | 在教室伦流澡到高潮h麻豆| 妺妺窝人体色www看人体| 国产无遮挡又黄又爽免费网站| 一本精品99久久精品77| 国产精品久久久久久不卡盗摄| 亚洲午夜无码av毛片久久| 狠狠色成人一区二区三区| 麻豆成人av不卡一二三区| 人人插人人插人人爽| 国语精品福利自产拍在线观看 | 色综合久久蜜芽国产精品| 久久精品国产精品久久久| 国产真实乱对白精彩久久|