在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CIDEC Antibody

CIDEC Antibody

  • 中文名稱(chēng)：
    CIDEC兔多克隆抗體
  • 貨號(hào)：
    CSB-PA087998
  • 規(guī)格：
    ￥1100
  • 圖片：
    • The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using CSB-PA087998(CIDEC Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA087998(CIDEC Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    Cell death activator antibody; Cell death activator CIDE-3 antibody; Cell death inducing DFFA like effector C antibody; Cell death inducing DFFA like effector protein C antibody; Cell death-inducing DFFA-like effector protein C antibody; CIDE 3 antibody; CIDE C antibody; CIDE3 antibody; CIDEC antibody; CIDEC_HUMAN antibody; Fat specific protein 27 antibody; Fat-specific protein FSP27 homolog antibody; FLJ20871 antibody; FPLD5 antibody; FSP27 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Fusion protein of Human CIDEC
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen affinity purification
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,IHC
  • 推薦稀釋比：
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    IHC 1:25-1:100
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair. Its role in neutral lipid transfer and lipid droplet enlargement is activated by the interaction with PLIN1. May act as a CEBPB coactivator in the white adipose tissue to control the expression of a subset of CEBPB downstream target genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH. When overexpressed in preadipocytes, induces apoptosis or increases cell susceptibility to apoptosis induced by serum deprivation or TGFB treatment. As mature adipocytes, that express high CIDEC levels, are quite resistant to apoptotic stimuli, the physiological significance of its role in apoptosis is unclear. May play a role in the modulation of the response to osmotic stress by preventing NFAT5 to translocate into the nucleus and activate its target genes expression.
  • 基因功能參考文獻(xiàn)：
    1. FTO increased the lipid accumulation in hepatocytes by increasing nuclear translocation of SREBP1c and SREBP1c maturation, thus improving the transcriptional activity of lipid droplet-associated protein CIDEC. PMID: 29486327
    2. this study has indicated that 3' UTR variation in CIDEC is associated with the risk of elevated fasting glucose, the progression of hypertriglyceridemia and hypertension, and the efficacy of angiotensin II-targeted antihypertensive agents. PMID: 28415694
    3. Two tissue-specific CIDEc isoforms had different roles in lipid deposition. PMID: 29080839
    4. data suggested that Cidec could interact with and down-regulate AMPKalpha through an ubiquitin-proteasome degradation pathway, which provided a possible mechanism of Cidec in promoting human adipocytes differentiation PMID: 26367078
    5. Hepatic expression of FSP27/CIDEC is highly up-regulated in in patients with alcoholic steatohepatitis and this up-regulation contributes to alcohol-induced liver damage. PMID: 26099526
    6. It is insinuated that VAT is associated with late phase obesity CIDEC decrease and insulin resistance, while pioglitazone enhances CIDEC through activation of PPAR-gamma, increases its expression, and decreases lipolysis. PMID: 25210844
    7. After bariatric surgery-induced weight loss, CIDEC/FSP27 gene/protein expression in SAT increased significantly. Findings suggest a positive functional interaction between CIDEC/FSP27 & mitochondrial biogenesis-related genes in human adipose tissue PMID: 24126816
    8. results demonstrate a crucial role for FSP27-ATGL interactions in regulating lipolysis, triglyceride accumulation, and insulin signaling in human adipocytes PMID: 24627478
    9. homo-dimeric structure of the CIDE-N domain of FSP27 will provide important information that will enable better understanding of the function of FSP27. PMID: 24025675
    10. CIDE proteins expression correlate with tumor and survival characteristics in patients with renal cell carcinoma. PMID: 23475172
    11. Fsp27/CIDEC is a CREB target gene induced during early fasting in liver and regulated by FA oxidation rate. PMID: 23220584
    12. The results suggest that FSP27 not only modulates LD homeostasis but also modulates the response to osmotic stress via a physical interaction with NFAT5 at the LD surface. PMID: 23233732
    13. The expression of CIDE-3 was decreased in hepatocellular carcinoma (HCC) tissue, compared to adjacent normal tissues, and CIDE-3 expression and HCC differentiation were positively correlated. PMID: 20957525
    14. Results demonstrated that CIDEC-induced apoptosis was independent of FADD, suggesting that CIDEC-induced apoptosis might be in a death-receptor-independent, caspase-8-dependent manner. PMID: 21865223
    15. Insulin regulates CIDEA and CIDEC expression via PI3K, and it regulates expression of each protein via Akt1/2-and JNK2-dependent pathways, respectively, in human adipocytes. PMID: 21636835
    16. These results suggest that CIDEA and CIDEC are novel genes regulated by insulin in human adipocytes and may play key roles in the effects of insulin, such as anti-apoptosis and lipid droplet formation. PMID: 20154362
    17. Fat-specific protein 27 undergoes ubiquitin-dependent degradation regulated by triacylglycerol synthesis and lipid droplet formation PMID: 20089860
    18. Following gastric bypass the hepatic expression of CIDEC is downregulated by marked weight loss. PMID: 19661960
    19. CIDEC is required for unilocular lipid droplet formation and optimal energy storage in human. PMID: 20049731
    20. cloning and characterization as a member of the cell-death-inducing DNA-fragmentation-factor (DFF45)-like effector family PMID: 12429024
    21. FSP27 binds to lipid droplets and regulates their enlargement PMID: 18334488
    22. CIDEC is a regulator of adipocyte lipid metabolism and may be important for the adipocyte to adapt to changes in energy availability. PMID: 18702959

    顯示更多

    收起更多

  • 相關(guān)疾病：
    Lipodystrophy, familial partial, 5 (FPLD5)
  • 亞細(xì)胞定位：
    Nucleus. Endoplasmic reticulum. Lipid droplet. Note=Diffuses quickly on lipid droplet surface, but becomes trapped and clustered at lipid droplet contact sites, thereby enabling its rapid enrichment at lipid droplet contact sites.
  • 組織特異性：
    Expressed mainly in adipose tissue, small intestine, heart, colon and stomach and, at lower levels, in brain, kidney and liver.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 24229

    OMIM: 612120

    KEGG: hsa:63924

    STRING: 9606.ENSP00000408631

    UniGene: Hs.567562



主站蜘蛛池模板： 国产无遮挡又黄又爽奶头| 欧美激情精品成人一区| 中文字幕无码视频专区| 色yeye香蕉凹凸视频在线观看| 在线岛国片免费无码av| 日本xxxx片免费观看| 国产在线 | 欧洲| 人妻体内射精一区二区三区| 亚洲中文在线精品国产| 天堂资源中文最新版在线一区 | 毛片大全真人在线| 精品国产经典三级在线看| 99久久无码私人网站| 国产新婚夫妇叫床声不断| 国产亚洲日韩在线播放更多| 四虎永久在线精品免费网站| 国产偷窥盗摄一区二区| 在线天堂新版最新版在线8| 国产人妻精品午夜福利免费| 日本熟妇厨房xxxxx乱| 午夜福利片手机在线播放| 亚洲熟妇国产熟妇肥婆| 欧美另类高清zo欧美| 久久本色成人综合网| 欧美丰满妇大ass| 国产女人高潮叫床视频| √最新版天堂资源网在线下载| 日韩av第一页在线播放| 国产精品青青在线观看爽香蕉| 国产精品老热丝在线观看| 亚洲另类激情综合偷自拍图| 人人妻人人超人人| 中文字幕精品视频在线看免费| 黑人猛挺进小莹的体内视频| 99香蕉国产精品偷在线观看| 亚洲午夜久久久无码精品网红a片| 亚洲日韩av片在线观看| 国产午夜精品理论片| 久久国产色av| 国产成人高清精品亚洲| 亚洲精品久久av无码麻|