在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CIDEA Antibody

CIDEA Antibody

  • 中文名稱：
    CIDEA兔多克隆抗體
  • 貨號：
    CSB-PA005431GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    CIDEA
  • 別名：
    CIDEACell death activator CIDE-A antibody; Cell death-inducing DFFA-like effector A antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human CIDEA
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity Purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價(jià)

靶點(diǎn)詳情

  • 功能：
    Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IGF1, PRLR, SOCS1, SOCS3, XDH, but not casein. By interacting with CEBPB, strengthens the association of CEBPB with the XDH promoter, increases histone acetylation and dissociates HDAC1 from the promoter. Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. When overexpressed, induces apoptosis. The physiological significance of its role in apoptosis is unclear.
  • 基因功能參考文獻(xiàn)：
    1. Cidea, unexpectedly, functions molecularly as an indirect inhibitor of thermogenesis via inhibition of UCP1 activity. PMID: 27923808
    2. These data establish a functional role for Cidea and suggest that, in humans, the association between Cidea levels in white fat and metabolic health is not only correlative but also causative. PMID: 26118629
    3. Since Cide-A protein plays a role in the development of metabolic diseases such as obesity, metabolic syndrome, type 2 diabetes and their vascular complications, CIDE -A gene and protein are potential therapeutic targets for these diseases. PMID: 24413203
    4. The lowest mean relative of the gene expression for CIDE-A was observed in the group of obese patients with aortic aneurysm and lipid disorders PMID: 25720106
    5. the association of tag-single nucleotide polymorphisms and haplotype structures of the CIDEA gene with obesity in a Han Chinese population, was investigated. PMID: 24057179
    6. CIDE proteins expression correlate with tumor and survival characteristics in patients with renal cell carcinoma. PMID: 23475172
    7. Insulin regulates CIDEA and CIDEC expression via PI3K, and it regulates expression of each protein via Akt1/2-and JNK2-dependent pathways, respectively, in human adipocytes. PMID: 21636835
    8. The proportion of subjects with CIDEA) gene V115F (G/T) polymorphism with phenotypes of metabolic syndrome in a Chinese population was significantly higher based on genotype, in the order: GG PMID: 21106268
    9. CIDEA binds to liver X receptors and regulates their activity in vitro. PMID: 21315073
    10. These data indicate that the carboxy-terminal domain of Cidea directs lipid droplet targeting, lipid droplet clustering, and triglyceride accumulation, whereas the amino terminal domain is required for Cidea-mediated development of enlarged lipid droplets PMID: 20810722
    11. CIDEC is essential for the differentiation of adipose tissue PMID: 20945533
    12. These results suggest that CIDEA and CIDEC are novel genes regulated by insulin in human adipocytes and may play key roles in the effects of insulin, such as anti-apoptosis and lipid droplet formation. PMID: 20154362
    13. Methylation status of CIDEA, HAAO and RXFP3 had significant association with microsatellite instability in endometrial tumors. PMID: 20211485
    14. We propose an important and human-specific role for CIDEA in lipolysis regulation and metabolic complications of obesity. PMID: 15919794
    15. results support a role for cell death-inducing DFFA (DNA fragmentation factor-alpha)-like effector A (CIDEA) alleles in human obesity PMID: 16186410
    16. deglycosylation of CIDE-A correlated with enhanced nuclear export of the protein, and that high level of nonglycosylated CIDE-A inhibited TGFbeta1-dependent cell death. PMID: 17080483
    17. No dysregulation of CIDEA expression was observed in individuals with the metabolic syndrome PMID: 17895319
    18. The expression of the CIDE-A gene was regulated by CpG methylation of the promoter region. PMID: 18033804
    19. F allele of the CIDEA gene may serve as a risk factor for phenotypes related to metabolic syndrome in Japanese men. PMID: 18328351
    20. Cidea and other lipid droplet proteins define a novel, highly regulated pathway of triglyceride deposition in human WAT. PMID: 18509062
    21. CIDEa is sequestered in mitochondria while transfer of this potentially dangerous protein from mitochondria into nucleus intensifies or even initiates apoptosis. PMID: 18645223
    22. CIDEA is involved in adipose tissue loss in cancer cachexia and this may, at least in part, be due to its ability to inactivate PDC, thereby switching substrate oxidation in human fat cells from glucose to FAs. PMID: 19010897

    顯示更多

    收起更多

  • 相關(guān)疾病：
    In omental and subcutaneous adipose tissue of obese patients matched for BMI, expression levels correlate with insulin sensitivity. Expression is increased 5-6 fold in the group of patients with high insulin sensitivity, compared to the insulin-resistant group. This observation is consistent with the idea that triglyceride storage in adipocytes plays an important role in sequestering triglycerides and fatty acids away from the circulation and peripheral tissues, thus enhancing insulin sensitivity in liver and muscle.
  • 亞細(xì)胞定位：
    Lipid droplet. Nucleus.
  • 組織特異性：
    Expressed in omental and subcutaneous adipose tissue (at protein level).
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1976

    OMIM: 604440

    KEGG: hsa:1149

    STRING: 9606.ENSP00000320209

    UniGene: Hs.249129



主站蜘蛛池模板： 亚洲人成小说网站色| av大尺度一区二区三区| 国产超级va在线观看视频| 国产97色在线 | 欧洲| 好爽好硬好深高潮视频456| 日韩人妻无码免费视频一区二区三区 | 色婷婷综合久久久久中文一区二区 | 熟妇人妻中文字幕无码老熟妇| 日本熟妇浓毛| 50路60路老熟妇啪啪| 又黄又爽吃奶视频在线观看| 男人边做边吃奶头视频| 无码中文人妻在线三区| 成人欧美一区二区三区在线| 黑人猛挺进小莹的体内视频| 色综合久久久久综合99| 人妻丝袜无码国产一区| 人妻少妇无码专视频在线| 国产98在线 | 欧美| 中文无码日韩欧| 国产午夜成人久久无码一区二区 | 人妻中文字幕乱人伦在线| 亚洲精品久久久无码av片软件| 精品久久久久久777米琪桃花| 日本老熟妇乱子伦视频| 亚洲aⅴ天堂av天堂无码 | 越南女子杂交内射bbwxz| 巨大巨粗巨长 黑人长吊| 后入内射无码人妻一区| 国产黄a三级三级三级av在线看| 色一情一乱一伦一区二区三区| 国产成人午夜福利在线小电影| 午夜无码一区二区三区在线| 人人爽人人澡人人人人妻| 国产精品白浆无码流出视频| 欧美日韩综合一区二区三区| 50路60路老熟妇啪啪| 人与禽交av在线播放| 国产成人精品自在线导航| 中日韩va无码中文字幕| 人妻丰满熟av无码区hd|