在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CIAPIN1 Antibody

  • 中文名稱:
    CIAPIN1兔多克隆抗體
  • 貨號:
    CSB-PA963186
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA963186(CIAPIN1 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA963186(CIAPIN1 Antibody) at dilution 1/60, on the right is treated with fusion protein. (Original magnification: ×200)
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    CIAPIN1
  • 別名:
    2810413N20Rik antibody; Anamorsin antibody; CIAPIN 1 antibody; CIAPIN1 antibody; CPIN1_HUMAN antibody; Cytokine induced apoptosis inhibitor 1 antibody; Cytokine-induced apoptosis inhibitor 1 antibody; DRE2 antibody; Fe-S cluster assembly protein DRE2 homolog antibody; Predicted protein of HQ0915 antibody; PRO0915 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Fusion protein of Human CIAPIN1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:50-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能:
    Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.
  • 基因功能參考文獻:
    1. the effects of CIAPIN-1 in chondrocytes, focusing on extracellular signal-regulated kinase (ERK)-1/2 and p38 kinase signaling PMID: 27644154
    2. results of the present study suggest that downregulation of the CIAPIN1 gene in multiple myeloma cells may be associated with the development of this disease. PMID: 25901506
    3. CIAPIN1 and ABCA13 may be novel markers of poor outcome in pre-chemotherapy serous carcinoma effusions. PMID: 25889687
    4. CIAPIN1 over-expression decreases NHE1 expression and ERK1/2 phosphorylation. PMID: 25724898
    5. lentivirus-vector-mediated RNAi targeting of CIAPIN1 is a potential approach to reverse MDR of breast cancer and CIAPIN1 may participate in MDR of breast cancer by regulating P-glycoprotein and P53 expression. PMID: 24676475
    6. the 25-kDa cleaved fragment of anamorsin was detected in post-mortem brains of Alzheimer and Parkinson disease patients PMID: 24973211
    7. The N-terminal methyltransferase-like domain of anamorsin probably functions as a structural scaffold to inhibit methyl transfers. PMID: 24123282
    8. CIAPIN1 targeted NHE1 to mediate differentiation of K562 cells via ERK1/2 pathway. PMID: 25043809
    9. Mossbauer and EPR spectra of human anamorsin show that both the M1 motif and the M2 motif bind independently a [2Fe-2S] cluster through the four cysteines of each motif. PMID: 23989406
    10. CIAPIN1 siRNA inhibited proliferation, migration and promotes apoptosis of vascular smooth muscle cells by regulating Bcl-2 and Bax. PMID: 23151078
    11. the molecular basis of recognition between Ndor1 and anamorsin and of the electron transfer process, was investigated. PMID: 23596212
    12. Elevated expression of nuclear CIAPIN1 negatively correlated with the survival of epithelial ovarian cancer patients PMID: 22713669
    13. In summary, our work revealed a novel function of CIAPIN1, which might possibly be used as an independent prognostic factor and a potential therapeutic target for pancreatic cancer PMID: 22677939
    14. Up-regulation of CIAPIN1 expression may play an important role in pathogenesis of leukemia. PMID: 21729524
    15. Anamorsin is a Mia40-dependent but ALR-independent IMS-protein and binds a [2Fe-2S] cluster before and after specific Mia40-driven Cys-oxidation. PMID: 21700214
    16. Results of immunohistochemical study showed that CIAPIN1 might play an important role in esophageal carcinogenesis, and it could be considered as a prognostic indicator in esophageal squamous cell carcinoma. PMID: 20411424
    17. Low expression of CIAPIN1 is associated with colorectal cancer. PMID: 20815902
    18. it is concluded that CIAPIN1 confers multidrug resistance in gastric cancer cells, likely by upregulating MDR-1 and MRP-1 PMID: 16410721
    19. CIAPIN1 was localized in both the cytoplasm and the nucleus and was accumulated in the nucleolus. Bioinformatic prediction disclosed a putative nuclear localization signal and a putative nuclear export signal within human CIAPIN1. PMID: 16957168
    20. CIAPIN1 might be a DNA or RNA methyltransferase. PMID: 17935775
    21. These findings suggest that downregulating CIAPIN1 could sensitize leukemia cells to chemotherapeutic drugs by downregulating MDR-1 and Bcl-2 and by upregulating Bax. PMID: 18059532
    22. anamorsin expression in DLBCL patients with a low IPI was shown to be an unfavorable biomarker; anamorsin might play some roles in the abnormal growth of DLBCL. PMID: 18203020
    23. CIAPIN1 is a suppressor of gastric cancer cell proliferation; CIAPIN1 might play an important role in the development of human gastric cancer. PMID: 18293492
    24. Knock down of CIAPIN1 by adenovirus-delivered siRNA may be a potential therapeutic strategy for treatment of hepatocellular carcinoma in which CIAPIN1 is overexpressed. PMID: 18299278
    25. correlation between CIAPIN1 down regulation and decreased MDR1 transcriptional activity were observed. PMID: 18389626
    26. the CIAPIN1 genet could be used as a clinical marker to identify patients with CCRCC. PMID: 19081179

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Nucleus. Mitochondrion intermembrane space.
  • 蛋白家族:
    Anamorsin family
  • 組織特異性:
    Ubiquitously expressed. Highly expressed in heart, liver and pancreas.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 28050

    OMIM: 608943

    KEGG: hsa:57019

    STRING: 9606.ENSP00000377914

    UniGene: Hs.4900



主站蜘蛛池模板: 蜜臀国产在线视频| 无码人妻巨屁股系列| 国内熟妇人妻色无码视频在线| 亚洲欧美综合精品二区| 久久精品久久久久观看99水蜜桃| 永久黄网站色视频免费| 又爽又黄无遮拦成人网站| 国内精品久久久久影院老司机 | 国产精品欧美久久久久无广告| 国产真人做爰视频免费| а天堂8中文最新版在线官网| 小宝贝荡货啊用力水湿aⅴ视频| 免费人成网站在线视频| 久久97超碰色中文字幕总站| 高潮毛片无遮挡高清免费| 在线日韩日本国产亚洲| 亚洲乱码av一区二区| 2021久久最新国产精品| 欧美一区二区三区成人片在线| 99精品一区二区三区无码吞精| 国产在线无码制服丝袜无码| 人妻丰满熟妇av无码区动漫| 国产精品久久久久久久久久久免费看| 亚洲欧美国产精品久久久久久久 | 爽爽午夜影视窝窝看片| 麻豆精品传媒一二三区艾秋| 亚洲成色www久久网站| 风韵饥渴少妇在线观看| 日本少妇浓毛bbwbbwbbw| 国产乱人伦中文无无码视频试看| 久久亚洲国产精品成人av秋霞 | 92久久精品一区二区| 亚洲中文字幕码在线电影| 国产成人精品午夜福利不卡| 国产熟女一区二区三区五月婷 | 国产内射爽爽大片视频社区在线| 久久亚洲精品ab无码播放| 美女又大又黄www免费网站| 强行糟蹋人妻hd中文| 色婷婷久久综合中文久久一本| 奇米777四色成人影视|