在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CHTOP Antibody

  • 中文名稱:
    CHTOP兔多克隆抗體
  • 貨號:
    CSB-PA003619GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CHTOP
  • 別名:
    C1orf77 antibody; chromatin target of chromatin target of PRMT1 protein antibody; Chromatin target of PRMT1 antibody; Chromatin target of PRMT1 protein antibody; Chromosome 1 open reading frame 77 antibody; CHTOP antibody; CHTOP_HUMAN antibody; DKFZp547E1010 antibody; FL- RP1-178F15.2 antibody; FL-SRAG antibody; FOP antibody; Friend of PRMT1 antibody; Friend of PRMT1 protein antibody; HT031 antibody; MGC131924 antibody; MGC86949 antibody; OTTHUMP00000035122 antibody; OTTHUMP00000035123 antibody; Pp7704 antibody; RP1 178F15.2 antibody; Small arginine- and glycine-rich protein antibody; Small protein rich in arginine and glycine antibody; SRAG antibody; SRAG-3 antibody; SRAG-5 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Human C1orf77
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays an important role in the ligand-dependent activation of estrogen receptor target genes. May play a role in the silencing of fetal globin genes. Recruits the 5FMC complex to ZNF148, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes. Plays an important role in the tumorigenicity of glioblastoma cells. Binds to 5-hydroxymethylcytosine (5hmC) and associates with the methylosome complex containing PRMT1, PRMT5, MEP50 and ERH. The CHTOP-methylosome complex associated with 5hmC is recruited to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of genes involved in glioblastomagenesis.; Required for effective mRNA nuclear export and is a component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production. Stimulates DDX39B ATPase and helicase activities. In cooperation with ALYREF/THOC4 enhances NXF1 RNA binding activity.
  • 基因功能參考文獻:
    1. the cellular level of Chtop is autoregulated via Int2 retention of its own mRNA, which subsequently undergoes NMD. PMID: 27683223
    2. Results suggest that 5hmC plays a critical role in glioblastomagenesis by recruiting the CHTOP-methylosome complex to selective sites on the chromosome, where it methylates H4R3 and activates the transcription of cancer-related genes. PMID: 25284789
    3. Chtop is a component of the dynamic TREX mRNA export complex that, along with Alyref, activates the ATPase and RNA helicase activities of Uap56. PMID: 23299939
    4. The recently identified chromatin factor Friend of Prmt1 (FOP) is a critical modulator of gamma-globin gene expression. PMID: 20688955
    5. Fop is tightly associated with chromatin, and that it is modified by both asymmetric and symmetric arginine methylation in vivo. Fop plays an important role in the ligand-dependent activation of estrogen receptor target genes, including TFF1 (pS2). PMID: 19858291
    6. The reduction in SRAG protein that occurs in proliferating cells was mapped with inhibitors to the G(2)/M phase of the cell cycle. As expected, the overexpression of SRAG reduced the percentage of cells in the G(2)/M phase and increased cell death. PMID: 19254951

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Nucleus, nucleolus. Nucleus, nucleoplasm. Nucleus speckle.
  • 組織特異性:
    Expressed in an erythroid progenitor cell line derived from peripheral blood. Expressed in glioblastoma cells.
  • 數據庫鏈接:

    HGNC: 24511

    OMIM: 614206

    KEGG: hsa:26097

    STRING: 9606.ENSP00000357683

    UniGene: Hs.611057



主站蜘蛛池模板: 精品一区二区三区在线视频| 亚洲午夜理论片在线观看| 亚洲精品suv精品一区二区| 亚洲色精品88色婷婷七月丁香| 一本一道久久a久久精品综合| 无遮挡边摸边吃奶边做视频| 亚洲欧美日韩二三区在线| 日本高清不卡aⅴ免费网站 | 色欲综合一区二区三区| 精品亚洲一区二区三区在线观看 | 欧美色欧美亚洲高清在线视频| 三级4级全黄60分钟| 一本丁香综合久久久久不卡网站| 国产午夜亚洲精品一区| 久久精品99国产精品日本| 亚洲欧美另类久久久精品能播放的| 欧美巨大xxxx做受高清| 国产最新av在线播放不卡| 无码人妻h动漫| 可以看三级的网站| 亚洲日韩性欧美中文字幕| 亚洲熟妇av综合网五月| 色狠狠av老熟女| 熟妇熟女乱妇乱女网站| 一区二三区国产好的精华液o9 | 国产乱人伦av在线a最新| 丰满人妻翻云覆雨呻吟视频| 日本大片免a费观看视频| 久久精品囯产精品亚洲| 国产黑色丝袜在线看片不卡顿| 国产真人做爰毛片视频直播| 青草影院内射中出高潮| 日本乱理伦片在线观看中文| 人人妻人人澡人人爽欧美一区双| 亚洲毛片不卡av在线播放一区| 精品久久久久久国产潘金莲| 加勒比东京热无码一区| 人妻丰满熟妞av无码区| 草草久久97超级碰碰碰| 亚洲国产欧美在线人成aaaa| 无码137片内射在线影院|