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  4. CHRND Antibody, Biotin conjugated

CHRND Antibody, Biotin conjugated

  • 中文名稱：
    CHRND兔多克隆抗體, Biotin偶聯
  • 貨號：
    CSB-PA005399LD01HU
  • 規格：
    ￥880
  • 其他：

產品詳情

  • 產品名稱：
    Rabbit anti-Homo sapiens (Human) CHRND Polyclonal antibody
  • Uniprot No.：
  • 基因名：
    CHRND
  • 別名：
    Acetylcholine receptor delta subunit antibody; Acetylcholine receptor subunit delta antibody; ACHD_HUMAN antibody; ACHRD antibody; Cholinergic receptor, nicotinic, delta polypeptide antibody; CHRND antibody; CMS2A antibody; FCCMS antibody; Nicotinic acetylcholine receptor delta polypeptide precursor antibody; SCCMS antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human
  • 免疫原：
    Recombinant Human Acetylcholine receptor subunit delta protein (334-471AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Biotin
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式：
    Liquid
  • 應用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • 基因功能參考文獻：
    1. Data suggest mutation in invariant Cys-loop of CHRND (D140N) observed in muscle of one patient (11 y/o girl) with congenital myasthenia (w/ severe muscle weakness) alters conformation of ligand/acetylcholine binding site and receptor functionality. PMID: 26698174
    2. This study showed that a single mutation of the delta subunit, L332P, allows the synapse in slow muscles to function but renders those in fast muscles almost nonfunctional. PMID: 25080583
    3. Results describe the effects of a point mutation in the AChR delta subunit from a congenital myasthenia patient. PMID: 18398509
  • 相關疾病：
    Multiple pterygium syndrome, lethal type (LMPS); Myasthenic syndrome, congenital, 3A, slow-channel (CMS3A); Myasthenic syndrome, congenital, 3B, fast-channel (CMS3B); Myasthenic syndrome, congenital, 3C, associated with acetylcholine receptor deficiency (CMS3C)
  • 亞細胞定位：
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Delta/CHRND sub-subfamily
  • 數據庫鏈接：

    HGNC: 1965

    OMIM: 100720

    KEGG: hsa:1144

    STRING: 9606.ENSP00000258385

    UniGene: Hs.156289



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