在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CHRNA1 Antibody

  • 中文名稱(chēng):
    CHRNA1兔多克隆抗體
  • 貨號(hào):
    CSB-PA587496
  • 規(guī)格:
    ¥1100
  • 圖片:
    • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA587496(CHRNA1 Antibody) at dilution 1/20, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    Acetylcholine receptor subunit alpha antibody; ACHA_HUMAN antibody; AChR antibody; ACHRA antibody; ACHRD antibody; CHNRA antibody; Cholinergic receptor nicotinic alpha 1 subunit antibody; Cholinergic receptor nicotinic alpha polypeptide 1 antibody; Cholinergic receptor; nicotinic; alpha polypeptide 1 (muscle) antibody; Chrna1 antibody; CMS1A antibody; CMS1B antibody; CMS2A antibody; FCCMS antibody; Nicotinic cholinergic receptor alpha 1 antibody; SCCMS antibody; Schizophrenia neurophysiologic defect candidate antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthetic peptide of Human CHRNA1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:2000-1:5000
    IHC 1:25-1:100
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane.
  • 基因功能參考文獻(xiàn):
    1. In our analysis, we found one pair of SNPs in CHRNA1 and CHRNA7, plus one pair of SNPs in CHRNA2 and CHRNA3 reached corrected significance in tests for GxG interaction. Our study suggested evidence of interactions between CHRNs in controlling the risk of NSCL/P. PMID: 29688589
    2. This study shown that the genetic analysis revealed that the very early onset JMG had a more prominent genetic predisposition in an autoantigen gene (CHRNA1). PMID: 28364296
    3. Data suggest that the mutations made the cholinergic receptor nicotinic alpha 1 subunit channel (CHRNA1) resistant to the antagonists, not by impairing antagonist binding, but rather by producing a gain-of-function phenotype, e.g. increased agonist sensitivity. PMID: 27649498
    4. Study indicated that nicotinic acetylcholine receptor alpha 1-subunit peptides may act as receptor decoy molecules and inhibit the binding of virus to the native host cell receptors and hence may reduce viral infection. PMID: 26656837
    5. ChRnA1 gene variants did not affect the pharmacodynamics of rocuronium. PMID: 25279974
    6. nicotine contributes to the progression and erlotinib-resistance of the NSCLC xenograft model via the cooperation between nAChR and EGFR. PMID: 25670150
    7. show that AON complementary to the 5' splice site of the exon was the most effective at exon skipping of the minigene with causative mutations, as well as endogenous wild-type CHRNA1 PMID: 25888793
    8. The CHRNA1 extracellular domain is an improved protein for use in antigen-specific Myasthenia Gravis therapeutic strategies. PMID: 24376846
    9. HnRNP L and hnRNP LL antagonistically modulate PTB-mediated splicing suppression of CHRNA1 pre-mRNA. PMID: 24121633
    10. High expression of CHRNA1 is associated with lung adenocarcinoma after complete resection. PMID: 23775407
    11. No mutations were found in CHRNG, CHRND and CHRNA1 genes of Indian families with Escobar syndrome. PMID: 23448903
    12. Findings identify a novel lung cancer risk locus on 2q31.1 which correlates with CHRNA1 expression and replicate previous associations on 15q25.1 in African-Americans. PMID: 23232035
    13. V188 is functionally linked to Y190 in the C-loop and to D200 in beta-strand 10 of the acetylcholine receptor alpha subunit, which connects to the M1 transmembrane domain PMID: 22728938
    14. Studies suggest that the receptor nAChRalpha1 is an important regulator of calpain-1 activation and inflammation in the chronic hypercholesterolemic nephropathy. PMID: 20661225
    15. expression of extracellular domain of human muscle acetylcholine receptor alpha subunit in yeast Pichia pastoris PMID: 12015305
    16. DNA analysis of a father and son with dominant fast channel congenital myasthenic syndrome revealed an AChR alpha-subunit F256L missense mutation affecting channel gating PMID: 15079006
    17. A good correlation was found between the expression of PAX3/7-FKHR and AChR, while MyoD1 was more sensitive but less specific. PMID: 16435141
    18. the interaction between alpha AChR M1 and M2 domains plays a key role in channel gating PMID: 17028140
    19. growth factor-induced HMVEC migration, a key angiogenesis event, requires nAChR activation--an effect mediated in part by nAChR-dependent regulation of thioredoxin activity. PMID: 17082486
    20. Here we describe a mechanism controlling thymic transcription of a prototypic tissue-restricted human auto-antigen gene, CHRNA1 PMID: 17687331
    21. No CHRNA1, CHRNB1, or CHRND mutations were detected, but a homozygous RAPSN frameshift mutation, c.1177-1178delAA, was identified in a family with three children affected with lethal fetal akinesia sequence. PMID: 18179903
    22. study reports homozygous nonsense mutations in CHRNA1 and CHRND and shows that they were lethal PMID: 18252226
    23. Presence of heterogeneous nuclear ribonucleoprotein H-binding motif in CHRNA1 close to the 3' end of an intron is an essential but underestimated splicing regulator of the downstream exon. PMID: 18806275

    顯示更多

    收起更多

  • 相關(guān)疾病:
    Multiple pterygium syndrome, lethal type (LMPS); Myasthenic syndrome, congenital, 1A, slow-channel (CMS1A); Myasthenic syndrome, congenital, 1B, fast-channel (CMS1B)
  • 亞細(xì)胞定位:
    Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.
  • 蛋白家族:
    Ligand-gated ion channel (TC 1.A.9) family, Acetylcholine receptor (TC 1.A.9.1) subfamily, Alpha-1/CHRNA1 sub-subfamily
  • 組織特異性:
    Isoform 1 is only expressed in skeletal muscle. Isoform 2 is constitutively expressed in skeletal muscle, brain, heart, kidney, liver, lung and thymus.
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 1955

    OMIM: 100690

    KEGG: hsa:1134

    STRING: 9606.ENSP00000261007

    UniGene: Hs.434479



主站蜘蛛池模板: 国产成人亚洲高清一区| 国内大量偷窥精品视频| 中文在线8资源库| 精品人妻少妇嫩草av无码专区| 伦理片午夜视频在线观看| 国产成人理论无码电影网| 欧美性受xxxx白人性爽| 久久精品中文字幕| 中文字幕人妻被公上司喝醉在线| 另类亚洲小说图片综合区| 日本熟妇乱子伦xxxx| 人妻无码久久精品| 亚洲精品国产av天美传媒| 亚洲精品乱码久久久久久日本麻豆| 国产人妻人伦精品久久久| 污污污污污污www网站免费| 麻豆国产va免费精品高清在线| 果冻传媒一区二区天美传媒| 五月天精品视频在线观看| 性猛交ⅹxxx富婆视频| 亚洲国产精品无码久久青草| 精品国产一区二区三区av色诱| 国产精品成人亚洲777| 亚洲桃色天堂网| 日本边添边摸边做边爱| 欧美不卡一区二区三区| 中文字幕乱码一区av久久不卡| 无码8090精品久久一区| 国产高清在线精品二区| 在线播放亚洲第一字幕| 国产又黄又爽又色的免费| 久九九久视频精品免费| 午夜成人鲁丝片午夜精品| 日韩不卡手机视频在线观看| 99精品产国品一二三产区| 福利姬国产精品一区在线| 久久大香香蕉国产| 久久精品亚洲男人的天堂| 人妻三级日本香港三级极97| 伊伊综合在线视频无码| 忘忧草日本在线www|