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CHPF Antibody

  • 中文名稱:
    CHPF兔多克隆抗體
  • 貨號:
    CSB-PA445330
  • 規格:
    ¥2024
  • 圖片:
    • Western blot analysis of extracts from LOVO cells and K562 cells, using CHSS2 antibody.
    • Immunohistochemistry analysis of paraffin-embedded human cervix carcinoma tissue using CHSS2 antibody.
    • Immunofluorescence analysis of MCF-7 cells, using CHSS2 antibody.
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CHPF Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Synthesized peptide derived from internal of Human CHSS2.
  • 免疫原種屬:
    Homo sapiens (Human)
  • 克隆類型:
    Polyclonal
  • 純化方式:
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC,IF
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:500-1:3000
    IHC 1:50-1:100
    IF 1:100-1:500
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Has both beta-1,3-glucuronic acid and beta-1,4-N-acetylgalactosamine transferase activity. Transfers glucuronic acid (GlcUA) from UDP-GlcUA and N-acetylgalactosamine (GalNAc) from UDP-GalNAc to the non-reducing end of the elongating chondroitin polymer. Isoform 2 may facilitate PRKN transport into the mitochondria. In collaboration with PRKN, isoform 2 may enhance cell viability and protect cells from oxidative stress.
  • 基因功能參考文獻:
    1. High CHPF expression is associated with gliomas. PMID: 28627702
    2. data suggest that TGF-beta stimulated the expression of ChPF and sGAG synthesis in nucleus pulposus cells through Smad3, RhoA/ROCK1 and the three MAPK signaling pathways. PMID: 28608941
    3. CHPF was found to be differentially methylated in human squamous cell carcinomas. PMID: 22461910
    4. study reports a novel protein named Klokin 1(a splice variant of chondroitin polymerizing factor) that transports Parkin to the mitochondria; findings indicate that mitochondrial Parkin prevents mitochondrial depolarization and that Klokin 1 may compensate for Parkin deficiency PMID: 22082830
    5. Chondroitin sulfate synthase-2/chondroitin polymerizing factor has two variants with distinct function PMID: 20729547
    6. chondroitin polymerizing activity requires concomitant expression of a ChPF with ChSy; coexpression of the ChPF and ChSy yielded markedly augmented glycosyltransferase activities, whereas simple mixing of the two separately expressed proteins did not. PMID: 12716890

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  • 亞細胞定位:
    [Isoform 1]: Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Cytoplasm, cytosol.; [Isoform 3]: Cytoplasm, cytosol. Mitochondrion.; [Isoform 2]: Mitochondrion matrix.
  • 蛋白家族:
    Chondroitin N-acetylgalactosaminyltransferase family
  • 組織特異性:
    Ubiquitous. Highly expressed in pancreas, ovary, brain, heart, skeletal muscle, colon, kidney, liver, stomach, spleen and placenta. Isoform 3 is also ubiquitous. Isoform 2 is expressed in brain, spleen, ovary, testis, lung and peripheral mononuclear cells
  • 數據庫鏈接:

    HGNC: 24291

    OMIM: 610405

    KEGG: hsa:79586

    STRING: 9606.ENSP00000243776

    UniGene: Hs.516711



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