在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CHN1 Antibody

  • 中文名稱:
    CHN1兔多克隆抗體
  • 貨號:
    CSB-PA005368GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CHN1
  • 別名:
    A-chimaerin antibody; Alpha-chimerin antibody; ARHGAP2 antibody; CHIN_HUMAN antibody; CHN antibody; Chn1 antibody; N chimaerin antibody; N chimerin antibody; N-chimaerin antibody; N-chimerin antibody; NC antibody; Rho GTPase-activating protein 2 antibody; RHOGAP2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human CHN1
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    GTPase-activating protein for p21-rac and a phorbol ester receptor. Involved in the assembly of neuronal locomotor circuits as a direct effector of EPHA4 in axon guidance.
  • 基因功能參考文獻:
    1. CHN1 mutations were identified in 2 bilateral cases and in 1 parent of 1 affected case. One mutation is novel and occurred with additional vertical gaze abnormalities. PMID: 29031989
    2. CHN1 and TNFAIP3 are candidate biomarkers for esophageal squamous cell carcinomas PMID: 27072986
    3. These findings reveal a role for ephrin bidirectional signaling upstream of mutant alpha2-chimaerin in Duane retraction syndrome, which may contribute to the selective vulnerability of abducens motor neurons in this disorder PMID: 28346224
    4. this study shows that serum chemerin is an independent risk factor of prognosis of non-small cell lung cancer patients PMID: 28160556
    5. reduced alpha1-chimaerin expression in the brain of Alzheimer's disease cases, suggesting a role in the upregulation of Rac1 activity during the disease process. PMID: 25676811
    6. The patients most similar belong to families with a small or absent cranial nerve VI and septo-optic hypoplasia who carry CHN1 mutations PMID: 25331612
    7. Analysis of the current pedigree expands the phenotypic spectrum of hyperactivating CHN1 mutations to include vertical strabismus and supraduction deficits in the absence of Duane retraction syndrome. PMID: 21715346
    8. Members of families segregating Duane retraction syndrome (DRS) as an autosomal dominant trait should be screened for mutations in the CHN1 gene, enhancing genetic counseling and permitting earlier diagnosis. PMID: 21555619
    9. We found no evidence for a causative involvement of CHN1 mutations in congenital ocular motor anomalies different from autosomal dominant Duane's retraction syndrome PMID: 20535495
    10. study concludes that CHN1 mutations are not a major cause of Duane's retraction syndrome among individuals with sporadic disease PMID: 20034095
    11. These two pedigrees double the published pedigrees known to map to the DURS2 locus and can thus contribute toward the search for the DURS2 gene PMID: 17197532
    12. DRS (Duane retraction syndrome) linked to the DURS2 locus is associated with bilateral abnormalities of many orbital motor nerves, and structural abnormalities of all EOMs except those innervated by the inferior division of CN3. PMID: 17197533
    13. Identify chimaerins as candidates for the downmodulation of Rac1 in T-lymphocytes and, in addition, uncover a novel regulatory mechanism that mediates their activation in T-cells. PMID: 18249095
    14. studying families with a variant form of Duane's retraction syndrome (DURS2-DRS), causative heterozygous missense mutations in CHN1 were identified; these are gain-of-function mutations that increase alpha2-chimaerin RacGAP activity PMID: 18653847
    15. analysis of an autoinhibitory mechanism that restricts C1 domain-mediated activation of the Rac-GAP alpha2-chimaerin PMID: 18826946
    16. Considerable intrafamilial clinical variability was observed in this Duane syndrome pedigree that carried a alpha2-chimaerin mutation PMID: 19541263

    顯示更多

    收起更多

  • 相關疾病:
    Duane retraction syndrome 2 (DURS2)
  • 組織特異性:
    In neurons in brain regions that are involved in learning and memory processes.
  • 數據庫鏈接:

    HGNC: 1943

    OMIM: 118423

    KEGG: hsa:1123

    STRING: 9606.ENSP00000386741

    UniGene: Hs.380138



主站蜘蛛池模板: 国产啪精品视频网站| 国产超碰人人做人人爽av大片 | 欧美人妻少妇精品久久黑人 | 九九影院午夜理论片少妇| 亚洲人成手机电影网站| 破了亲妺妺的处免费视频国产| 久久在线视频免费观看| 久久久精品欧美一区二区免费| 不卡无码人妻一区二区三区| 无码人妻一区二区三区av | 久久国产精品免费一区二区三区| 亚洲精品成人老司机影视| 欧美日韩精品一区二区性色a+v| 国产又大又硬又粗| 996久久国产精品线观看| 亚洲成av大片大片在线播放| 漂亮人妻被强中文字幕久久| 成人av无码一区二区三区| 亚洲一区二区三区在线播放无码| 午夜福利午夜福利1000| 2019日韩中文字幕mv| 少妇挑战三个黑人惨叫4p国语| 2020最新无码福利视频 | 成人免费ā片在线观看| 国产女同疯狂作爱系列| 超级碰97直线国产免费公开| 99热精品毛片全部国产无缓冲| 试看120分钟做受小视频| 97国产精品麻豆性色aⅴ人妻波 | 国产精品人成视频免费国产| 蜜臀精品无码av在线播放| 美女张开腿黄网站免费下载| 狠狠色丁香五月综合缴情婷婷五月 | 久久久久人妻精品一区蜜桃| 7777精品伊久久久大香线蕉| 99热在线精品免费全部my| 亚洲欧美精品aaaaaa片| 国产99在线 | 免费| 婷婷丁香五月亚洲中文字幕| 精品久久久久久人妻无码中文字幕| 性强烈的欧美三级视频|