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CHMP2A Antibody

  • 中文名稱:
    CHMP2A兔多克隆抗體
  • 貨號:
    CSB-PA04524A0Rb
  • 規格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: CHMP2A antibody at 2µg/ml
      Lane 1: EC109 whole cell lysate
      Lane 2: 293T whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/15000 dilution
      Predicted band size: 26 kDa
      Observed band size: 16 kDa
    • Immunohistochemistry of paraffin-embedded human placenta tissue using CSB-PA04524A0Rb at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CHMP2A Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    BC 2 antibody; BC2 antibody; Charged multivesicular body protein 2a antibody; CHM2A_HUMAN antibody; CHMP2 antibody; CHMP2a antibody; Chromatin modifying protein 2a antibody; Chromatin-modifying protein 2a antibody; hVps2 1 antibody; hVps2-1 antibody; putative breast adenocarcinoma marker antibody; Putative breast adenocarcinoma marker BC-2 antibody; Putative breast adenocarcinoma marker BC2 antibody; Vacuolar protein sorting associated protein 2 1 antibody; Vacuolar protein sorting-associated protein 2-1 antibody; Vps2 1 antibody; VPS2 antibody; Vps2-1 antibody; VPS2A antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Charged multivesicular body protein 2a protein (1-222AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,CHMP2A Antibody (CSB-PA04524A0Rb),的標記方式是Non-conjugated。對于CHMP2A Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA04524B0Rb CHMP2A Antibody, HRP conjugated ELISA
    FITC CSB-PA04524C0Rb CHMP2A Antibody, FITC conjugated
    Biotin CSB-PA04524D0Rb CHMP2A Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Probable core component of the endosomal sorting required for transport complex III (ESCRT-III) which is involved in multivesicular bodies (MVBs) formation and sorting of endosomal cargo proteins into MVBs. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. The MVB pathway appears to require the sequential function of ESCRT-O, -I,-II and -III complexes. ESCRT-III proteins mostly dissociate from the invaginating membrane before the ILV is released. The ESCRT machinery also functions in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis. Together with SPAST, the ESCRT-III complex promotes nuclear envelope sealing and mitotic spindle disassembly during late anaphase. ESCRT-III proteins are believed to mediate the necessary vesicle extrusion and/or membrane fission activities, possibly in conjunction with the AAA ATPase VPS4.; (Microbial infection) The ESCRT machinery functions in topologically equivalent membrane fission events, such as the budding of enveloped viruses (HIV-1 and other lentiviruses). Involved in HIV-1 p6- and p9-dependent virus release.
  • 基因功能參考文獻:
    1. CHMP2A is the ESCRT-III component that regulates phagophore closure PMID: 30030437
    2. Data show that gamma2-adaptin in MVB sorting specifically interacts with the ESCRT subunits Vps28 and CHMP2A. PMID: 20708039
    3. study found the ESCRT-III proteins CHMP2A & CHMP3 could assemble in vitro into helical tubular structures that expose their membrane interaction sites on the outside of the tubule; VPS4 could bind on the inside of the tubule & disassemble the tubes PMID: 18687924
  • 亞細胞定位:
    Late endosome membrane; Peripheral membrane protein; Cytoplasmic side. Note=Localizes to the midbody of dividing cells. Localized in two distinct rings on either side of the Fleming body.
  • 蛋白家族:
    SNF7 family
  • 數據庫鏈接:

    HGNC: 30216

    OMIM: 610893

    KEGG: hsa:27243

    STRING: 9606.ENSP00000310440

    UniGene: Hs.12107



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