在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CHKA Antibody

  • 中文名稱:
    CHKA兔多克隆抗體
  • 貨號:
    CSB-PA005353GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
    CHKA
  • 別名:
    CHKA antibody; CHK antibody; CKI antibody; Choline kinase alpha antibody; CK antibody; EC 2.7.1.32 antibody; CHETK-alpha antibody; Ethanolamine kinase antibody; EK antibody; EC 2.7.1.82 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Mouse,Rat
  • 免疫原:
    Human CHKA
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,WB,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Has a key role in phospholipid biosynthesis and may contribute to tumor cell growth. Catalyzes the first step in phosphatidylcholine biosynthesis. Contributes to phosphatidylethanolamine biosynthesis. Phosphorylates choline and ethanolamine. Has higher activity with choline.
  • 基因功能參考文獻:
    1. miR-876-5p was able to significantly decrease the expression level of choline kinase alpha mRNA. PMID: 29568919
    2. There is no correlation between single CHKA rs7928739 polymorphism and the incidence of intrauterine fetal death. PMID: 28509322
    3. This study presents the detail the 2.35 A structure of choline kinase alpha in complex with inhibitor TCD-717. PMID: 29389115
    4. Results indicate that choline kinase alpha (CHKA) contributes to tumor progression and metastasis and may serve as a prognostic biomarker and potential therapeutic target in colorectal carcinoma (CRC). PMID: 27556502
    5. hCKalpha functions as an indispensable regulator that bridges PI4KIIIalpha and hepatitis C virus NS5A and potentiates NS5A-stimulated PI4KIIIalpha activity, which then facilitates the targeting of the ternary complex to the endoplasmic reticulum for viral replication. PMID: 28566381
    6. We found levels of CHKA to be increased in human HCCs compared to nontumor tissues, and increased expression to be associated with tumor aggressiveness. Overexpression of CHKA in HCC cell lines increased their invasiveness, resistance to EGFR inhibitors, and ability to form metastatic tumors in mice by promoting interaction of EGFR with mechanistic target of rapamycin complex 2. PMID: 28065789
    7. These findings demonstrate that hCKalpha forms a complex with hepatitis C virus NS5A and that hCKalpha activity enhances the targeting of the complex to the endoplasmic reticulum, where hCKalpha protein, not activity, mediates NS5A binding to NS5B, thereby promoting functional membranous viral replication complex assembly and viral RNA replication. PMID: 27489281
    8. Study shows increased CHKA expression in pancreatic ductal adenocarcinoma tumors and may be a predictive marker of response to chemotherapy. PMID: 26769123
    9. These data also support the approach of antitumor strategies that destabilize Chk-alpha protein or downregulate PtdCho in breast cancer treatment. PMID: 26503172
    10. Downregulation of choline kinase-alpha enhances autophagy in tamoxifen-resistant breast cancer cells. PMID: 26496360
    11. CHKA can act as an AR chaperone, providing, to our knowledge, the first evidence for kinases as molecular chaperones, making CHKA both a marker of tumor progression and a potential therapeutic target for PCa. PMID: 26657335
    12. Identify choline kinase alpha as a key regulator of glutathione-dependent antioxidant cell defense in ovarian carcinoma. PMID: 25796169
    13. choline kinase alpha is inhibited by a near-infrared fluorescent carbocyanine PMID: 25028471
    14. Increased expression of CHKA is seen in malignant lesions of prostate cancer PMID: 26041862
    15. Chokalpha possessed oncogenic activity and could be a potential therapeutic target in T-cell lymphoma , as well as other hematological malignancies with interrupted Ras signaling pathways PMID: 25768400
    16. Downregulation of Chk-alpha with siRNA increased PLD1 expression, and downregulation of PLD1 increased Chk-alpha expression. PMID: 24556997
    17. there is a role for the ChoKalpha protein in promoting cancer cell survival that is independent of its catalytic activity. PMID: 25522435
    18. The significance of CHKA overexpression on a TMA. PMID: 25267063
    19. Our data suggest that choline kinase and its product phosphocholine are required for the normal growth and mineralization of MG-63 cells. PMID: 24583375
    20. pharmacological inhibition of ChoKalpha induces cancer cell death through a mechanism that involves the activation of exaggerated and persistent ER stress supported by CHOP overproduction. PMID: 24287694
    21. Chk-alpha expression and the effect of its downregulation in human umbilical vein endothelial cells, is reported. PMID: 23775813
    22. In EOC that CHKA downregulation significantly decreased the aggressive EOC cell. PMID: 24281000
    23. CHKA SNPs (rs3794186 and rs11481) are not associated with HCC development; however, rs3794186 may correlate with serum AFP levels in HCC. PMID: 22972156
    24. High choline kinase A expression is associated with colorectal cancer. PMID: 23762272
    25. A combination of initial velocity and product inhibition studies, together with the kinetic and structural characterisation of a novel ChoKalpha inhibitor is used to support a mechanism of action for human ChoKalpha. PMID: 23416529
    26. HK2 and CKA expression may have biologic and prognostic significance in hepatocellular carcinoma, with tumor HK2 expression being a potential independent predictor of survival. PMID: 23071593
    27. ASAH1 inhibition synergistically sensitizes lung cancer cells resistant to the antiproliferative effect of choline kinase alpha inhibitors. PMID: 22515519
    28. Data show choline kinase alpha (CHKalpha) expressed in both cytoplasm and nucleus in malignant lesions. PMID: 22038995
    29. these results strongly implicate a new c-Src-dependent link between CHKA and EGFR, which contributes to the regulation of cell proliferation and tumorigenesis. PMID: 21822308
    30. kinetic studies revealed that HC-3 is a much more potent inhibitor for ChoKalpha isoforms (alpha1 and alpha2) compared with ChoKbeta. PMID: 20299452
    31. From our data, we proposed that Choline kinase plays a key role in regulating Akt(ser473) phosphorylation, thereby promoting cell survival and proliferation PMID: 20042122
    32. ChoKalpha and ChoKbeta isoforms have different physiological roles and implications in human carcinogenesis PMID: 19915674
    33. Data show that RNA silencing of choline kinase in HeLa cells completely abrogates the high concentration of phosphocholine, which in turn decreases phosphatidylcholine, phosphatidic acid and signaling through the MAPK and PI3K/AKT pathways. PMID: 19855431
    34. activity regulated by Ras proteins through Ral-GDS and PI-3-kinase; has role in malignant transformation PMID: 11840339
    35. ChoK overexpression was found in 17% of the samples. ChoK may be related to the development of human breast cancer, suggesting that this finding may suggest a novel antitumoral strategy. PMID: 12082619
    36. upregulation of choline kinase is a frequent feature in human tumor-derived cell lines and in lung, prostate, and colorectal cancers PMID: 12176020
    37. ChoK may have a role in carcinogenesis PMID: 16820874
    38. Analyses showed genotype effects of CHKA genes on spina bifida risk, but did not show evidence of gene-nutrient. PMID: 17184542
    39. These data suggest that HIF-1 activation of HREs within the putative chk-a promoter region can increase Chk-A expression within hypoxic environments, consequently increasing cellular PC and tCho levels within these environments. PMID: 18172309
    40. The molecular basis to understand the connection between phospholipids metabolism and cell cycle regulation through choline kinase is reported. PMID: 18296102
    41. The rates of choline kinase reaction in cell lysates of MDA-MB-231 breast, PC-3 prostate and HeLa cervical cancer cells and in solutions of purified human ChoK, was measured. PMID: 19156696
    42. ChoKalpha plays a role in the aggressiveness of bladder tumors and constitutes a new approach for bladder cancer treatment. PMID: 19448670

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm.
  • 蛋白家族:
    Choline/ethanolamine kinase family
  • 數據庫鏈接:

    HGNC: 1937

    OMIM: 118491

    KEGG: hsa:1119

    STRING: 9606.ENSP00000265689

    UniGene: Hs.77221



主站蜘蛛池模板: 1000部拍拍拍18勿入免费视频| 精品久久国产综合婷婷五月| 男女性爽大片视频免费看| 亚洲午夜福利在线视频| 在线观看成人无码中文av天堂不卡| 米奇7777狠狠狠狠视频影院 | 无码人妻丰满熟妇奶水区码| 精品午夜福利无人区乱码一区| 国产精品你懂的在线播放| 国产人成无码视频在线| 影音先锋日日狠狠久久| 亚洲精品少妇高清30p| 国产深夜男女无套内射| 毛片无码一区二区三区a片视频 | 无码h黄肉3d动漫在线观看| 亚洲精品一区二区三区新线路 | 无码精品日韩专区| 好男人社区影院www| 亚洲午夜福利在线观看| 亚洲一二三四2021不卡| 成年女人看片永久免费视频| 乌克兰少妇xxxx做受| 国产97色在线 | 免费| 亚洲最新无码成av人| 伊人色综合一区二区三区影院视频| 无码专区一va亚洲v专区在线| 久久久久无码中| 97国产超碰一区二区三区| 柠檬福利第一导航在线| 亚洲日韩成人无码| 2019最新久久久视频精品| 国产精品亚洲а∨怡红院| 亚洲一区二区三区日本久久九| 色综合欧美在线视频区| 天天躁日日躁狠狠躁2018| 亚洲中文字慕日产2021| 亚洲视频一区| 亚洲色18禁成人网站www| 十八禁午夜福利免费网站| 国产偷国产偷亚洲高清app| 中文在线а√在线|