在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CHIT1 Antibody, FITC conjugated

  • 中文名稱:
    CHIT1兔多克隆抗體, FITC偶聯
  • 貨號:
    CSB-PA623792LC01HU
  • 規格:
    ¥880
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) CHIT1 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    CHIT1
  • 別名:
    Chitotriosidase-1 (EC 3.2.1.14) (Chitinase-1), CHIT1
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Chitotriosidase-1 protein (215-430aa)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    FITC
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產品提供形式:
    Liquid
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Degrades chitin, chitotriose and chitobiose. May participate in the defense against nematodes and other pathogens. Isoform 3 has no enzymatic activity.
  • 基因功能參考文獻:
    1. CHIT1 might be considered as a circulating biomarker in polycythemia vera. Additional studies are needed to clarify the role of CHIT1 in promoting disease progression and bone marrow fibrosis in polycythemia vera. PMID: 29993340
    2. Data suggest that up-regulation of amniotic fluid chitotriosidase may serve as prenatal diagnostic biomarker for lysosomal storage disorders, more specifically for Gaucher and Niemann-Pick A/B diseases; these findings appear to result from gene duplication. This study was conducted in India. PMID: 30205089
    3. Circulating chitotriosidase is a test which can potentially be used for the monitoring of critical limb ischemia patients without other inflammatory conditions. PMID: 29263045
    4. All patients with NPC1 mutations had high ChT activity, high CCL18/PARC concentrations and/or Niemann-Pick disease type C suspicion index scores >/=70. PMID: 28222799
    5. The total allele frequency of the dup24bp in the CHIT1 gene in the Ukrainian population was determined, which amounted to 0.26 (323/1244) that is higher than in the Western European population. PMID: 29227082
    6. the two variations of CHIT1, rs61745299 and rs35920428, increase expression of the gene and are associated with colorectal cancer in Chinese Han populations PMID: 27153562
    7. SCD children are at risk of developing premature atherogenic changes. Plasma chitotriosidase and CIMT may represent useful predictors of these changes. PMID: 28677113
    8. chitotriosidase as a possible chronic inflammation marker in children with common variable immunodeficiency and early atherosclerosis PMID: 27705887
    9. Processivity and the rate constant of dissociation of Human chitotriosidase (HCHT) were found to be in-between those, characteristic to processive exo-enzymes, like SmChiA and randomly acting non-processive endo-enzymes, like SmChiC. Apart from increasing the affinity for chitin, CBM had no major effect on kinetic properties of HCHT. PMID: 28129403
    10. PMA stimulation and preincubation with rhDNase increased CHIT-1 activity in culture supernatants from non-CF and CF donors.Stimulation of isolated leucocytes with PMA and treatment with rhDNase interfered with anti-fungal defence mechanisms. PMID: 27324468
    11. X-Ray crystal structure of the full length CHIT1 reveals features of its chitin binding domain. PMID: 27111557
    12. Deletion in the CHIT1 gene is associated with Chitotriosidase deficiency disease. PMID: 27129798
    13. confirmed the strong association between chitotriosidase activity and the markers of progressive kidney disease in a cohort of type 2 diabetic patients; also demonstrated that diabetic patients genetically lacking the full active enzyme (with at least one CHIT1 functionally mutated allele) are at lower risk of developing nephropathy compared to patients having wild genotype PMID: 26589000
    14. BALF chitotriosidase activity is increased in patients with sarcoidosis. PMID: 26847098
    15. study indicates that genotype analysis by HRM-PCR is a fast, reliable, and highly accurate screening approach for identifying the 24-bp duplication in CHIT1 exon 10. PMID: 26624962
    16. CHIT-1 is expressed during the process of differentiation and maturation of dendritic cells in a time-dependent manner. PMID: 26026464
    17. No correlation between CHIT1 24-base pair duplication polymorphism and prognosis in sarcoidosis was shown, but possible protective role of homozygous condition for CHIT1 24-base pair duplication polymorphism is suggested. PMID: 26422563
    18. the presence of product polymers of 40 sugar moieties and higher starts to disappear already at 8% degradation for HCHT50-W31A. Such behavior contrast that of the wild type and HCHT-W218A and resembles the action of endo-nonprocessive chitinases PMID: 26621384
    19. Our findings indicate that chitotriosidase and S10012A are useful in diagnosis and detection of subclinical inflammation and/or assessment of disease activity in FMF patients. PMID: 26339162
    20. Serum CHIT1 rs3831317 and CHI3L1 rs4950928 genotypes were examined in patients with asthma and COPD in a European study to evaluate factors that affect chitinase levels in patients with severe airway disease. PMID: 26372680
    21. study found the 24-bp insertion in the gene for chitotriosidase was associated with the development of mycetoma caused by M. mycetomatis PMID: 26332238
    22. The study presents new X-ray data to resolutions of between 0.95 and 1.10 A for CHIT1 in apo and pseudo-apo forms and in complex with chitobiose, an N-acetylglucosamine (NAG) dimer. PMID: 26143917
    23. elevated in pregnant women with threatened preterm labor PMID: 25005858
    24. The two Chit1 isoforms combine features of exo-processive and endo-nonprocessive chitinases with the somewhat unusual carbohydrate binding module 14 to reach a high degree of efficiency. PMID: 26116146
    25. Catalytic deficiency of chitotriosidase has a very high frequency in Amerindians highly exposed to chitin from enteroparasites and diet. PMID: 25256524
    26. Report a significant association between 24 bp duplication in CHIT1 gene polymorphism and asthma in the studied North Indian population. PMID: 24928104
    27. c.1049_1072dup24 in CHIT1 presents an allele frequency of 0.22 in Spain.p.G102S in CHIT1 presents an allele frequency of 0.27 in Spain.Ser102 CHIT1 allele caused a significant reduction of chitotriosidase activity. PMID: 24060732
    28. The results of the current study suggest that CHIT1 duplication cannot be the sole explanation for Aspergillus positive sputum in CF patients. PMID: 23359515
    29. may be a useful biochemical marker of fetal compromise that reflects the severity of fetoplacental blood flow resistance in pregnancies complicated by preeclampsia PMID: 23844836
    30. Glycolipids or glycoproteins with LacNAc and LacdiNAc represent potential CHIT1 substrates. PMID: 24462685
    31. age, gender, TNFalpha, hemocysteine, sleep efficiency and waist circumference were responsible for approximately 14% of CHIT variation. PMID: 23692992
    32. HCHT with higher endo-activity and a higher transglycosylation potential. PMID: 24036453
    33. increased serum levels is a good prtognostic marker for recovery from World Trade Center lung injury PMID: 23744081
    34. The association of chitotriosidase (ChT) with age remains significant after controlling for neopterin and IL-6 changes with age, suggesting that ChT levels reflect a macrophage state distinct from acute macrophage activation or inflammatory state. PMID: 23525479
    35. serum chitotriosidase is more highly expressed in ST-segment elevation myocardial infaction than in non ST-segment elevation myocardial infarction and unstable angina pectoris PMID: 22986554
    36. These results indicate that the nonsynonymous A442G polymorphism in CHIT1 is associated with risk of atopy. PMID: 23706714
    37. CCL18 and YKL-40 levels and CHIT1 activity are enhanced in allergic airway inflammation and thus may contribute to airway remodelling in asthma. PMID: 23331560
    38. results showed that the expression of AMCase and CHIT-1 were differently modulated in monocyte macrophages at different stage of maturation. The behavior of these two active chitinase suggests that in the immune response their role is complementary. PMID: 23129258
    39. Serum CHIT concentrations are significantly higher in patients than in healthy controls and are directly correlated with angiotensin converting enzyme (ACE)levels. PMID: 22878841
    40. This work analyses the chitin-binding and catalytic domains of the human macrophage chitotriosidase and investigates the physiological role of this glycoside hydrolase in a complex mechanism such as the innate immune system, esp. its antifungal activity. PMID: 21674664
    41. allelic and genotypic frequencies of the 24-bp Dup in CHIT1 gene in homozygotes and heterozygotes were in accordance to worldwide reports PMID: 23234739
    42. Data suggest that serum chitotriosidase is increased during first trimester in women who later develop pre-eclampsia as compared to control subjects; serum metastin is decreased; serum placenta growth factor is decreased. PMID: 22770630
    43. elevates in polycystic ovary syndrome independent of obesity PMID: 22718099
    44. Patients with systemic sclerosis and interstitial lung disease show high levels of circulating Chit1 activity that correlate with disease severity. PMID: 22826322
    45. Serum Chitotriosidase activity was significantly higher in the preeclampsia group as compared with levels in the control group. PMID: 22183425
    46. study demonstrated genetic associations between chitinase gene variants and lung function level and rate of decline in chronic obstructive pulmonary disease patients from the Lung Health Study PMID: 22200767
    47. Data suggest that serum chitotriosidase activity (a possible marker of inflammatory processes) is increased in obese adolescents with impaired glucose tolerance. PMID: 22206738
    48. activity of chitotriosidase in plasma was statistically higher in severe endometriosis patients than women without endometriosis PMID: 22132778
    49. Data confirm elevation of chitotriosidase activity in patients with active cerebral adrenoleukodystrophy, and suggest that these levels predict prognosis of patients with C-ALD undergoing transplantation. PMID: 22014002
    50. Human chitotriosidase degrades chitosan primarily via an endoprocessive mechanism: the main hydrolysis product is chitobiose, (i.e., the acetylated dimer) fully consistent with its role as a "normal" processive enzyme. PMID: 22192075

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted. Lysosome. Note=A small proportion is lysosomal.
  • 蛋白家族:
    Glycosyl hydrolase 18 family, Chitinase class II subfamily
  • 組織特異性:
    Detected in spleen. Secreted by cultured macrophages.
  • 數據庫鏈接:

    HGNC: 1936

    OMIM: 600031

    KEGG: hsa:1118

    STRING: 9606.ENSP00000356198

    UniGene: Hs.201688



主站蜘蛛池模板: 人人超人人超碰超国产| 成在人线av无码免观看午夜网 | 无码少妇a片一区二区三区| 无遮挡激情视频国产在线观看| av无码一区二区二三区1区6区| 蜜桃av蜜臀av色欲av麻| 台湾无码一区二区| 亚洲成av人片一区二区密柚| 亚洲va久久久噜噜噜久久男同| 国产高潮流白浆视频| 少妇久久久久久被弄高潮| 成人午夜视频精品一区| 免费高清av一区二区三区| www一区二区乱码www| 国产人妻777人伦精品hd| 精品 日韩 国产 欧美 视频| 人人做人人爽国产视| 国产裸体歌舞一区二区| 精品亚洲麻豆1区2区3区| 亚洲精品喷潮一区二区三区| 亚洲人成伊人成综合网中文| 无遮挡18禁啪啪免费观看| 欧美又粗又大aaa片| 免费无码毛片一区二三区| 中文国产乱码在线人妻一区二区| 无码午夜人妻一区二区不卡视频 | 爽爽影院免费观看视频| 精产国品一二三产区蘑菇视频| 99久久亚洲综合精品成人| 中文字幕精品av乱码在线| 国产三级在线观看完整版| 国产男女无遮挡猛进猛出| 亚洲欧美自拍制服另类图区| 国产精品亚洲a∨天堂| 中文字幕一区二区三区四区五区| 国产女同疯狂作爱系列| 亚洲国产成人久久久网站| 久久精品第九区免费观看| 亚洲一区二区三区写真| 337p人体 欧洲人体 亚洲| 国产国产裸模裸模私拍视频|