在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CHIA Antibody

CHIA Antibody

  • 中文名稱(chēng)：
    CHIA兔多克隆抗體
  • 貨號(hào)：
    CSB-PA005348GA01HU
  • 規(guī)格：
    ￥3,900
  • 其他：

產(chǎn)品詳情

  • Uniprot No.：
  • 基因名：
    CHIA
  • 別名：
    Acidic mammalian chitinase [Precursor] antibody; Acidic mammalian chitinase antibody; AMCase antibody; Chia antibody; CHIA_HUMAN antibody; CHIT2 antibody; chitinase; acidic antibody; DKFZp313J1722 antibody; ECF L antibody; Lung specific protein TSA1902 antibody; Lung-specific protein TSA1902 antibody; RP5 1125M8.1 antibody; TSA1902 antibody
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human,Mouse,Rat
  • 免疫原：
    Human CHIA
  • 免疫原種屬：
    Homo sapiens (Human)
  • 抗體亞型：
    IgG
  • 純化方式：
    Antigen Affinity purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA,WB,IF
  • Protocols：
  • 儲(chǔ)存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能：
    Degrades chitin and chitotriose. May participate in the defense against nematodes, fungi and other pathogens. Plays a role in T-helper cell type 2 (Th2) immune response. Contributes to the response to IL-13 and inflammation in response to IL-13. Stimulates chemokine production by pulmonary epithelial cells. Protects lung epithelial cells against apoptosis and promotes phosphorylation of AKT1. Its function in the inflammatory response and in protecting cells against apoptosis is inhibited by allosamidin, suggesting that the function of this protein depends on carbohydrate binding.
  • 基因功能參考文獻(xiàn)：
    1. rs10494132 polymorphism of CHIA might be a risk factor for asthma. PMID: 29233108
    2. we showed that M at the position 61 is highly conserved in the many mammals other than orangutan and humans. In addition, introduction of M61R and M61I to WT mouse AMCase lead to a significant reduction of its chitinolytic activity. Taken together, our present and previous data by Seibold et al. (2009) indicate that G339T (R61M) in humans is associated with asthma protection in the fashion of gain of function PMID: 27702777
    3. This is the first report on the association between low-frequency and common variants in the chitinases-related genes CHIA and CHI3L1 with the intensity of specific IgE to ABA-1 in a population naturally exposed to Ascaris and with Bet v 1 in a Swedish population. PMID: 27977724
    4. These data provide the experimental evidence that telomere shortening and related inflammatory proteins are associated with human IgAN, and it could be a new direction for the disease progression study. PMID: 24903994
    5. loss of acidic chitinase expression is a promising marker for corpus atrophy PMID: 24119614
    6. results showed that the expression of AMCase and CHIT-1 were differently modulated in monocyte macrophages at different stage of maturation. The behavior of these two active chitinase suggests that in the immune response their role is complementary. PMID: 23129258
    7. study demonstrated genetic associations between chitinase gene variants and lung function level and rate of decline in chronic obstructive pulmonary disease patients from the Lung Health Study; also functional effect of the rs3818822 polymorphism on AMCase levels and activity was demonstrated PMID: 22200767
    8. increased chitinolytic activity in nasal polyps PMID: 21711963
    9. Report increased CSF chitinase levels in patients with neuromyelitis optica and relapsing remitting multiple sclerosis. PMID: 21159721
    10. A ten base pair insertion in the second exon in the 5'UTR region of the AMCase gene may modify the gene expression and thus may affect the severity of asthma. PMID: 21511453
    11. Results showed the presence of CHIT1 and AMCase mRNA in gastric mucosa and the correlation with the presence of H. pylori was significant only for CHIT1 but not for AMCase expression. PMID: 19242357
    12. Environmental exposure to fungi does not modify the effect of CHIA SNPs on severe asthma exacerbations PMID: 20538957
    13. The levels of expression of AMCase and chitotriosidase mRNAs and proteins were increased in allergic turbinate mucosa compared with normal turbinate mucosa. PMID: 20422678
    14. Our study found no associations between single nucleotide polymorphisms in the genes CHIT1, CHIA, and CHI3L1 and asthma, changes in lung physiology, or allergy-related phenotypes in subjects with mild-to-moderate asthma PMID: 20226308
    15. expressed in exaggerated quantities in human asthma PMID: 15192232
    16. human AMCase has only one pH optimum for k(cat)/K(m) between pH 4 and 5. Steady state kinetics shows that human AMCase has "low" intrinsic transglycosidase activity, which leads to the observation of apparent substrate inhibition. PMID: 16584180
    17. results establish a significant association of CHIA with atopic asthma and serum total IgE levels in the Indian population PMID: 18602573
    18. lung epithelial cells secrete AMCase via an EGFR-dependent pathway that is activated by ADAM17 and mediates its effects via Ras. PMID: 18824549
    19. The three-dimensional (3D) model of the human acidic mammalian chitinase (hAMCase) was constructed based on the crystal structure of the human chitotriosidase (EC 3.2.1.44, PDB code 1HKK) by using InsightII/Homology module. PMID: 19085022
    20. secreted AMCase feeds back in an autocrine and/or paracrine manner to protect pulmonary epithelial cells from growth factor withdrawal- and Fas ligand-induced apoptosis PMID: 19342690
    21. Genetic association analyses of AMCase haplotypes for asthma revealed significant protective associations between the variant haplotype in several asthma cohorts. PMID: 19435888
    22. novel asthma susceptibility genes; review of genetic and fuctional studies PMID: 19644363

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    [Isoform 1]: Secreted. Note=Secretion depends on EGFR activity.; [Isoform 2]: Cytoplasm.; [Isoform 3]: Cytoplasm.
  • 蛋白家族：
    Glycosyl hydrolase 18 family, Chitinase class II subfamily
  • 組織特異性：
    Detected in lung epithelial cells from asthma patients (at protein level). Highly expressed in stomach. Detected at lower levels in lung.
  • 數(shù)據(jù)庫(kù)鏈接：

    HGNC: 17432

    OMIM: 606080

    KEGG: hsa:27159

    STRING: 9606.ENSP00000341828

    UniGene: Hs.128814



主站蜘蛛池模板： 亚洲午夜高清国产拍| 精品久久一区二区乱码| 久久午夜色播影院| 久久精品aⅴ无码中文字字幕| 日本中文字幕在线| 麻豆果冻传媒精品| 中文av岛国无码免费播放| 中文字幕久久综合伊人| 久久国产免费观看精品3| 国产成人一区二区三区免费| yy111111少妇无码影院| 男ji大巴进入女人的视频小说| 国内精品伊人久久久久影院对白| 大香网伊人久久综合网2018| 中文字幕无码第1页| 99久久久无码国产精品免费| 久久视频这里只有精品在线观看| 亚洲中文字幕aⅴ天堂| 久久婷婷五月综合色中文字幕| 无码人妻品一区二区三区精99| 疯狂迎合进入强壮公的视频| 久久久国产精品黄毛片| 国产成人无码aⅴ片在线观看| 亚洲综合色婷婷七月丁香| 亚洲精品人成网线在播放va | 99er热精品视频| 色噜噜狠狠一区二区三区| 老子午夜理论影院理论| 欧美精品中文字幕在线视| 欧美丰满熟妇xxxx性ppx人交| 久久九九av免费精品| 欧美乱大交aaaa片if| 男人边吃奶边揉好爽免费视频 | 精品av综合导航| 卡一卡二卡三免费视频| 亚洲2021av天堂手机版| 国产 日韩 中文字幕 制服| 日本精品人妻无码77777| 欧美亅性猛交内射| 又色又爽又黄的美女裸体网站| 久久精品九九热无码免贵|