在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CHD2 Antibody

  • 中文名稱:
    CHD2兔多克隆抗體
  • 貨號:
    CSB-PA005327GA01HU
  • 規格:
    ¥3,900
  • 其他:

產品詳情

  • Uniprot No.:
  • 基因名:
  • 別名:
    2810013C04Rik antibody; 2810040A01Rik antibody; 5630401D06Rik antibody; AI851092 antibody; ATP dependent helicase CHD2 antibody; ATP-dependent helicase CHD2 antibody; BC029703 antibody; CHD 2 antibody; CHD-2 antibody; CHD2 antibody; CHD2_HUMAN antibody; chromodomain helicase dna binding protein antibody; Chromodomain-helicase-DNA-binding protein 2 antibody; DKFZp547I1315 antibody; DKFZp686E01200 antibody; DKFZP781D1727 antibody; EC 3.6.1.- antibody; EEOC antibody; FLJ38614 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human,Rat
  • 免疫原:
    Human CHD2
  • 免疫原種屬:
    Homo sapiens (Human)
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA,IHC
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. Involved in myogenesis via interaction with MYOD1: binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression.
  • 基因功能參考文獻:
    1. Germline mosaicism resulted in a CHD2 gene missense variant and the development of autism spectrum disorder in two siblings. PMID: 28960266
    2. study reports monozygotic twins with a global neurodevelopmental delay associated with an autism spectrum disorder, hypotonia, postnatal microcephaly, stereotypic movements and circadian rhythm alterations in association with late-onset epilepsy; identified a CHD2 mutation, previously described in association with a phenotypic spectrum overlapping our patients' phenotype PMID: 26754451
    3. Results indicate a PARP1-dependent mechanism that regulates non-homologous end-joining through localized chromatin expansion and deposition of the histone variant H3.3 by CHD2 at DNA breaks promoting DNA repair. PMID: 26895424
    4. CHD2 mutations are responsible in rare cases for generalized epilepsy with myoclonic-atonic seizures. PMID: 26262932
    5. CHD2 is a cancer driver and has a role as chromatin remodeler in chronic lymphocytic leukemia. PMID: 26031915
    6. CHD2 mutation is the first identified cause of the archetypal generalized photosensitive epilepsy syndrome PMID: 25783594
    7. The phenotypic spectrum of CHD2 encephalopathy has distinctive features of myoclonic epilepsy with marked photosensitivity. PMID: 25672921
    8. Human CHD2 is a chromatin assembly ATPase regulated by its chromatin- and DNA-binding domains. PMID: 25384982
    9. Our findings suggest that CHD2 mutations are important in the etiological spectrum of Lennox-Gastaut syndrome. PMID: 24614520
    10. De novo loss-of-function mutations in CHD2 are a cause of epileptic encephalopathy with generalized seizures. PMID: 24207121
    11. De novo CHD2 and SYNGAP1 mutations are new causes of epileptic encephalopathies, accounting for 1.2% and 1% of cases, respectively. PMID: 23708187
    12. detected a homozygous deletion of chromosomal region 15q26.2 in the cell line HDLM2 encompasing RGMA and CHD2 PMID: 17606441

    顯示更多

    收起更多

  • 相關疾?。?/div>
    Epileptic encephalopathy, childhood-onset (EEOC)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    SNF2/RAD54 helicase family
  • 數據庫鏈接:

    HGNC: 1917

    OMIM: 602119

    KEGG: hsa:1106

    STRING: 9606.ENSP00000377747

    UniGene: Hs.220864



主站蜘蛛池模板: 亚洲精品亚洲人成在线下载| 亚洲高清成人aⅴ片| 中文字幕aav| 最近最好的中文字幕2019免费| 欧美性xxxxx极品少妇直播| 国产精品欧美久久久久久日本一道| 又粗又黄又硬又爽的免费视频| 国产sm调教折磨视频失禁| 无码一卡二卡三卡四卡| 亚洲最大成人av在线天堂网| 精品国产美女福到在线不卡| 亚洲日韩乱码中文无码蜜桃臀| 国产无套内射普通话对白| 伊人久久大香线蕉av波多野结衣| 婷婷网亚洲色偷偷男人的天堂| 国产精品亚洲а∨无码播放不卡 | 中文字幕无码不卡一区二区三区 | 中文乱码字幕高清一区二区| 美女裸免费观看网站| 性按摩玩人妻hd中文字幕| 国产精品永久免费| 亚洲国产成人爱av在线播放| 日本三级带日本三级带黄| 少妇高潮av久久久久久| 男人扒开添女人下部免费视频 | 可以直接看的无码av| 精品人妻无码一区二区三区| 日韩av无码一区二区三区不卡毛片| 天天综合爱天天综合色| 国产精品igao视频| 国产精品无码专区久久久| 国内丰满熟女出轨videos| 成人女人看片免费视频放人| 日本大尺度吃奶呻吟视频| 东京热人妻无码一区二区av| 天天躁日日躁狠狠躁人妻| 特黄aaaaaaa片免费视频| 亚洲午夜福利av一区二区无码| 国产成人手机高清在线观看网站 | 亚洲精品久久中文字幕| 天堂资源在线www在线观看|