在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. Home
  2. 抗體
  3. 多克隆抗體
  4. CH25H Antibody, HRP conjugated

CH25H Antibody, HRP conjugated

  • 中文名稱：
    CH25H兔多克隆抗體, HRP偶聯(lián)
  • 貨號：
    CSB-PA005307LB01HU
  • 規(guī)格：
    ￥880
  • 其他：

產(chǎn)品詳情

  • 產(chǎn)品名稱：
    Rabbit anti-Homo sapiens (Human) CH25H Polyclonal antibody
  • Uniprot No.：
  • 基因名：
  • 別名：
    CH25H; Cholesterol 25-hydroxylase; Cholesterol 25-monooxygenase; h25OH
  • 宿主：
    Rabbit
  • 反應(yīng)種屬：
    Human
  • 免疫原：
    Recombinant Human Cholesterol 25-hydroxylase protein (142-272AA)
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標(biāo)記方式：
    HRP
  • 克隆類型：
    Polyclonal
  • 抗體亞型：
    IgG
  • 純化方式：
    >95%, Protein G purified
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
  • 產(chǎn)品提供形式：
    Liquid
  • 應(yīng)用范圍：
    ELISA
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點詳情

  • 功能：
    Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. Plays a key role in cell positioning and movement in lymphoid tissues: 25-hydroxycholesterol is an intermediate in biosynthesis of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC), an oxysterol that acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. As an interferon-stimulated gene, has broad antiviral activities against a wide range of enveloped viruses, such as vesicular stomatitis virus (VSV) and SARS coronavirus-2 (SARS-CoV-2). Its product, 25-hydroxycholesterol, activates the ER-localized enzyme ACAT to induce internalization of accessible cholesterol on the plasma membrane and restricts SARS-CoV-2 S protein-mediated fusion which inhibits virus replication. In testis, production of 25-hydroxycholesterol by macrophages plays a role in Leydig cell differentiation.
  • 基因功能參考文獻(xiàn)：
    1. We examined whether 25HC restricts infection by mammalian reovirus. Results suggest that 25HC inhibits the efficiency of cellular entry of reovirus virions, which may require specific endosomal membrane dynamics for efficient membrane penetration. PMID: 29950420
    2. We detected Cholesterol 25-hydroxylase, the enzyme responsible for 25-HC production, in human spermatozoa at the level of the neck and the post acrosomal area. Upon incubation with spermatozoa, 25-HC induced calcium and cholesterol transients in connection with the acrosomal reaction. PMID: 27912195
    3. Exome analysis in 212 multiple sclerosis and 14 neuromyelitis optica patients identified a rare CH25H p.Q17H mutation in two NMO patients of Asian ancestry. In addition, association analysis of common CH25H variants. PMID: 26857497
    4. Infection with HCV causes up-regulation of interferon-inducible CH25H in vivo. PMID: 25999047
    5. These results demonstrate that CH25H constitutes a primary innate response against hepatitis C virus infection through regulating host lipid metabolism. PMID: 25903345
    6. Cholesterol 25-hydroxylase production by dendritic cells and macrophages is regulated by type I interferons. PMID: 20699362
    7. Based on the results of genome-wide screens, along with biological studies, we selected three genes as candidates for AD risk factors: ATP-binding cassette transporter A1 (ABCA1), cholesterol 25-hydroxylase (CH25H) and cholesterol 24-hydroxylase (CH24H). PMID: 16157450

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Sterol desaturase family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 1907

    OMIM: 604551

    KEGG: hsa:9023

    STRING: 9606.ENSP00000360918

    UniGene: Hs.47357



主站蜘蛛池模板： 日韩人妻少妇一区二区| 亚洲欧美综合国产精品二区| av综合网男人的天堂| 特黄三级又爽又粗又大| 成人国产一区二区三区| 蜜臀亚洲精品国产aⅴ综合第一| 欧美性群另类交| 在线精品无码字幕无码av| 亚洲精华国产精华精华液网站| 亚洲欧美日韩综合久久久| 欧美人与动zozo在线播放| 十八禁av无码免费网站| 国产午夜精品一区二区| 日韩精品无码一本二本三本色| 亚洲卡一卡二卡三新区乱码| 亚洲老熟女性亚洲| 少妇人妻偷人精品一区二区| 亚洲国产综合av在线观看| 好紧好爽好深再快点av在线| 国产精品人人妻人人爽人人牛| 亚洲精品～无码抽插| 国产自偷在线拍精品热| 囯产精品一区二区三区线| 日本大尺度吃奶呻吟视频| 亚洲最大成人一区久久久| 99精品国产福利一区二区| 中国美女毛茸茸撒尿| 亚洲妇熟xxxx妇色黄| 亚洲无av码在线中文字幕| 亚洲午夜福利院在线观看| 国产亚洲精品久久久久久久久动漫| 亚洲中文在线播放一区| 久久亚洲欧美国产精品| 国产在线无码一区二区三区视频| 亚洲国产精品久久亚洲精品 | 日本在线a一区视频高清视频 | 欧美老熟妇videos极品另类| 国产99视频精品免费视看9| 亚洲一区二区三区高清在线看| 午夜影视免费| 免费播放一区二区三区|