在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

CFL2 Antibody

  • 中文名稱:
    CFL2兔多克隆抗體
  • 貨號:
    CSB-PA005281ESR1HU
  • 規(guī)格:
    ¥440
  • 圖片:
    • Western blot
      All lanes: CFL2 antibody at 3.75µg/ml
      Lane 1: Mouse brain tissue
      Lane 2: Mouse liver tissue
      Lane 3: Mouse lung tissue
      Lane 4: LO2 whole cell lysate
      Lane 5: Hela whole cell lysate
      Lane 6: A549 whole cell lysate
      Secondary
      Goat polyclonal to rabbit IgG at 1/10000 dilution
      Predicted band size: 19, 17 kDa
      Observed band size: 19 kDa
    • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA005281ESR1HU at dilution of 1:100
    • Immunohistochemistry of paraffin-embedded human heart tissue using CSB-PA005281ESR1HU at dilution of 1:100
  • 其他:

產(chǎn)品詳情

  • 產(chǎn)品名稱:
    Rabbit anti-Homo sapiens (Human) CFL2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
  • 別名:
    CFL 2 antibody; CFL2 antibody; COF2_HUMAN antibody; Cofilin 2 muscle antibody; Cofilin antibody; Cofilin muscle antibody; Cofilin muscle isoform antibody; Cofilin-2 antibody; Cofilin2 antibody; muscle isoform antibody; NEM 7 antibody; NEM7 antibody
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human, Mouse
  • 免疫原:
    Recombinant Human Cofilin-2 protein (1-166AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen Affinity Purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA, WB, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    WB 1:1000-1:5000
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評價

靶點(diǎn)詳情

  • 功能:
    Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. Its F-actin depolymerization activity is regulated by association with CSPR3. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is the major component of intranuclear and cytoplasmic actin rods. Required for muscle maintenance. May play a role during the exchange of alpha-actin forms during the early postnatal remodeling of the sarcomere.
  • 基因功能參考文獻(xiàn):
    1. Here we report atomic-level characterization by magic angle spinning (MAS) NMR of the muscle isoform of human cofilin 2 (CFL2) bound to F-actin. We demonstrate that resonance assignments for the majority of atoms are readily accomplished and we derive the intermolecular interface between CFL2 and F-actin. PMID: 28303963
    2. The secreted levels of the cofilin-2 protein in radioresistant NPC patients were significantly higher than those of radiosensitive cases. PMID: 29664897
    3. miR-3189-3p mimics enhanced the effects of the S100A4 siRNA on the inhibition of gastric cancer cell proliferation and migration by targeting CFL2. PMID: 29342841
    4. The greatest levels of circulating miR-297 and miR-19b-3p with its common target CFL2 are associated with metastatic prostate cancer. PMID: 28091918
    5. The serum lever of Alzheimer's disease were increase and the expression of clf2 strongly correlated with the Mini-Mental State Examination scores of the AD patients PMID: 25502766
    6. In primary tumours, both desmin and CFL2 expression predicted improved overall survival in multivariate analyses PMID: 24889065
    7. Cofilin 2 phosphorylation and genetic overexpression plays a role in the pathogenesis of idiopathic dilated cardiomyopthay. PMID: 25814227
    8. patients with severe nemaline myopathy should be screened for mutations in CFL2. PMID: 24610938
    9. A novel homozygous missense mutation in exon 2 (c.19G>A, p.Val7Met) of CFL2 was identified in two siblings with congenital myopathy. PMID: 22560515
    10. the cofilin-induced change in the filament twist is due to a unique conformation of the actin molecule unrelated to any previously observed state PMID: 22158895
    11. PHD2 affects cell migration and F-actin formation via RhoA/rho-associated kinase-dependent cofilin phosphorylation PMID: 20801873
    12. FXa-mediated sustained cofilin inactivation leads to stabilization of actin filaments incompatible with migration PMID: 20347121
    13. actin depolymerizing factor/cofilins play an active role in establishing new interprotomer interfaces in F-actin that substitute for disrupted or weakened (as in ADP-actin) longitudinal contacts in filaments PMID: 16530787
    14. CFL2, encoding the actin-binding protein muscle cofilin-2, is mutated in two siblings with congenital myopathy. PMID: 17160903
    15. Resting T cells from infected patients carry significantly higher levels of active cofilin. PMID: 18928553
    16. MLP binds directly to CFL2 in human cardiac and skeletal muscles. PMID: 19752190

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Nemaline myopathy 7 (NEM7)
  • 亞細(xì)胞定位:
    Nucleus matrix. Cytoplasm, cytoskeleton.
  • 蛋白家族:
    Actin-binding proteins ADF family
  • 組織特異性:
    Isoform CFL2b is expressed predominantly in skeletal muscle and heart. Isoform CFL2a is expressed in various tissues.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 1875

    OMIM: 601443

    KEGG: hsa:1073

    STRING: 9606.ENSP00000298159

    UniGene: Hs.180141



主站蜘蛛池模板: 无码高潮少妇毛多水多水免费| 日本乱偷人妻中文字幕| 亚洲色婷婷一区二区三区| 久久久久99人妻一区二区三区| 国产如狼似虎富婆找强壮黑人| 免费国产va在线观看中文字| 天天爱天天做狠狠久久做| 女人被弄到高潮的免费视频| 久久无码中文字幕无码| 国产美女精品视频线播放| 成人网站在线进入爽爽爽| 亚洲∧v久久久无码精品| 国产精品女同一区二区在线 | 亚洲一区二区三区丝袜| 亚洲熟女精品中文字幕| 国产精品天干天干在线综合| 中文字幕日韩一区二区不卡| 欧美freesex黑人又粗又大| 亚洲在av人极品无码| 蜜臀少妇人妻在线| 国产人与禽zoz0性伦多活几年| 苍井空亚洲精品aa片在线播放| 狠狠久久久久综合成人影院| 亚州中文字幕午夜福利电影| 福利一区二区三区视频在线观看| 中文中幕a在线| 天天槽夜夜槽槽不停| 国产在线精品一区二区中文| 亚洲乱码中文字幕在线| 国产精品亚洲二区在线播放| 天堂在线.www天堂在线资源| 亚洲老妇色熟女老太| 日韩精品无码专区免费视频| 无线乱码一二三区免费看| 成人小说亚洲一区二区三区| 成 人 在 线 免费观看| 国产xxx视频在线观看软件| 伊人亚洲大杳蕉色无码| 丰满少妇大力进入| 美女黄18以下禁止观看| 大j8黑人w巨大888a片|