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CFAP410 Antibody

  • 中文名稱:
    CFAP410兔多克隆抗體
  • 貨號:
    CSB-PA003758LA01HU
  • 規格:
    ¥440
  • 圖片:
    • Immunohistochemistry of paraffin-embedded human gastric cancer using CSB-PA003758LA01HU at dilution of 1:100
  • 其他:

產品詳情

  • 產品名稱:
    Rabbit anti-Homo sapiens (Human) C21orf2 Polyclonal antibody
  • Uniprot No.:
  • 基因名:
    C21orf2
  • 別名:
    A2 antibody; C21orf HUMF09G8.5 antibody; C21orf-HUMF09G8.5 antibody; C21orf2 antibody; Chromosome 21 open reading frame 2 antibody; CU002_HUMAN antibody; Hypothetical protein LOC755 antibody; Nuclear encoded mitochondrial protein cDNA A2 YF5 antibody; Protein C21orf2 antibody; Uncharacterized protein C21orf2 antibody; YF 5 antibody; YF5 antibody; YF5/A2 antibody
  • 宿主:
    Rabbit
  • 反應種屬:
    Human
  • 免疫原:
    Recombinant Human Cilia- and flagella-associated protein 410 protein (1-200AA)
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標記方式:
    Non-conjugated

    本頁面中的產品,CFAP410 Antibody (CSB-PA003758LA01HU),的標記方式是Non-conjugated。對于CFAP410 Antibody,我們還提供其他標記。見下表:

    可提供標記
    標記方式 貨號 產品名稱 應用
    HRP CSB-PA003758LB01HU CFAP410 Antibody, HRP conjugated ELISA
    FITC CSB-PA003758LC01HU CFAP410 Antibody, FITC conjugated
    Biotin CSB-PA003758LD01HU CFAP410 Antibody, Biotin conjugated ELISA
  • 克隆類型:
    Polyclonal
  • 抗體亞型:
    IgG
  • 純化方式:
    >95%, Protein G purified
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    Preservative: 0.03% Proclin 300
    Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
  • 產品提供形式:
    Liquid
  • 應用范圍:
    ELISA, IHC
  • 推薦稀釋比:
    Application Recommended Dilution
    IHC 1:20-1:200
  • Protocols:
  • 儲存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能:
    Plays a role in cilia formation and/or maintenance. Plays a role in the regulation of cell morphology and cytoskeletal organization. Involved in DNA damage repair.
  • 基因功能參考文獻:
    1. Identification of a homozygous C21orf2 mutation in this case emphasizes the value of exome sequencing for simultaneously screening known genes and identifying novel genes.the severity of thoracic restriction in this case adds to the phenotypic spectrum attributable to C21orf2 mutations. PMID: 28422394
    2. Mutation in C21ORF2 gene is associated with amyotrophic lateral sclerosis. PMID: 27455348
    3. reduced levels of functional C21orf2 induced photoreceptor degradation through abnormal cilia formation, leading to arRP or arCRD in the retina. PMID: 27548899
    4. Analysis of patients without C21orf2 mutation indicated genetic heterogeneity of axial SMD. Functional data in chondrocyte suggest C21orf2 is implicated in cartilage differentiation PMID: 26974433
    5. C21ORF2 functions in the same pathway as NEK1 in DNA damage repair. PMID: 26290490
    6. This retinal dystrophy phenotype is caused by recessive mutations in C21orf2 and can be considered a retinal ciliopathy as C21orf2 encodes a protein that localises to photoreceptor ciliary structures. PMID: 26294103
    7. Downregulated protein level of C21orf2 in adult brain of patients with Down syndrome (DS) in contrast to Alzheimer's disease indicates that it can be considered specific for changes in DS. PMID: 15068244

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  • 相關疾病:
    Retinal dystrophy with or without macular staphyloma (RDMS); Spondylometaphyseal dysplasia, axial (SMDAX)
  • 亞細胞定位:
    Mitochondrion. Cytoplasm, cytoskeleton, cilium basal body. Cell projection, cilium, photoreceptor outer segment. Cytoplasm.
  • 組織特異性:
    Widely expressed. Expressed in the retina.
  • 數據庫鏈接:

    HGNC: 1260

    OMIM: 602271

    KEGG: hsa:755

    STRING: 9606.ENSP00000344566

    UniGene: Hs.517331



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