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CERS3 Antibody

  • 中文名稱:
    CERS3兔多克隆抗體
  • 貨號(hào):
    CSB-PA142124
  • 規(guī)格:
    ¥1100
  • 圖片:
    • Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: TM4 cells, Primary antibody: CSB-PA142124(CERS3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes
  • 其他:

產(chǎn)品詳情

  • Uniprot No.:
  • 基因名:
    CERS3
  • 別名:
    CERS3; LASS3; Ceramide synthase 3; CerS3; Dihydroceramide synthase 3; LAG1 longevity assurance homolog 3; Sphingosine N-acyltransferase CERS3; Ultra-long-chain ceramide synthase CERS3; Very-long-chain ceramide synthase CERS3
  • 宿主:
    Rabbit
  • 反應(yīng)種屬:
    Human
  • 免疫原:
    Synthetic peptide of Human CERS3
  • 免疫原種屬:
    Homo sapiens (Human)
  • 標(biāo)記方式:
    Non-conjugated
  • 抗體亞型:
    IgG
  • 純化方式:
    Antigen affinity purification
  • 濃度:
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液:
    -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
  • 產(chǎn)品提供形式:
    Liquid
  • 應(yīng)用范圍:
    ELISA,WB
  • 推薦稀釋比:
    Application Recommended Dilution
    ELISA 1:1000-1:2000
    WB 1:200-1:1000
  • Protocols:
  • 儲(chǔ)存條件:
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途:
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

  • 功能:
    Ceramide synthase that catalyzes the transfer of the acyl chain from acyl-CoA to a sphingoid base, with high selectivity toward very- and ultra-long-chain fatty acyl-CoA (chain length greater than C22). N-acylates sphinganine and sphingosine bases to form dihydroceramides and ceramides in de novo synthesis and salvage pathways, respectively. It is crucial for the synthesis of ultra-long-chain ceramides in the epidermis, to maintain epidermal lipid homeostasis and terminal differentiation.
  • 基因功能參考文獻(xiàn):
    1. Novel mutations in CERS3 co-segregated with the ichthyosis phenotype in six Iranian families. PMID: 28875980
    2. testis-specific SLs, which we also link to CerS3 in human testis, are quintessential for male fertility. PMID: 26045466
    3. Our findings demonstrate that synthesis of very long chain ceramides by CerS3 is a crucial early step for the skin barrier formation and link disorders presenting with congenital ichthyosis to defects in sphingolipid metabolism and lipid architecture. PMID: 23549421
    4. these data present a novel pathway involved in ARCI development and, moreover, provide the first evidence that CERS3 plays an essential role in human sphingolipid metabolism for the maintenance of epidermal lipid homeostasis. PMID: 23754960
  • 相關(guān)疾?。?/div>
    Ichthyosis, congenital, autosomal recessive 9 (ARCI9)
  • 亞細(xì)胞定位:
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 組織特異性:
    Expressed in the epidermis, where it localizes at the interface between the stratum granulosum and the stratum corneum (at protein level).
  • 數(shù)據(jù)庫(kù)鏈接:

    HGNC: 23752

    OMIM: 615023

    KEGG: hsa:204219

    STRING: 9606.ENSP00000284382

    UniGene: Hs.662371



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