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  4. CER1 Antibody

CER1 Antibody

  • 中文名稱：
    CER1兔多克隆抗體
  • 貨號：
    CSB-PA005669
  • 規格：
    ￥1090
  • 圖片：
    • Western Blot analysis of MCF-7 cells using Cerberus Polyclonal Antibody.
  • 其他：

產品詳情

  • Uniprot No.：
  • 基因名：
  • 別名：
    CER 1 antibody; cer1 antibody; CER1_HUMAN antibody; Cerberus 1 (Xenopus laevis) homolog (cysteine knot superfamily) antibody; Cerberus 1 antibody; Cerberus 1 cysteine knot superfamily homolog (Xenopus laevis) antibody; Cerberus antibody; Cerberus related 1 antibody; Cerberus related protein antibody; Cerberus-related protein antibody; Cerberus1 antibody; DAN domain family member 4 antibody; DAND 4 antibody; DAND4 antibody; MGC119894 antibody; MGC119895 antibody; MGC96951 antibody
  • 宿主：
    Rabbit
  • 反應種屬：
    Human,Rat
  • 免疫原：
    Synthesized peptide derived from the Internal region of Human Cerberus.
  • 免疫原種屬：
    Homo sapiens (Human)
  • 標記方式：
    Non-conjugated
  • 抗體亞型：
    IgG
  • 純化方式：
    The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
  • 濃度：
    It differs from different batches. Please contact us to confirm it.
  • 保存緩沖液：
    Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
  • 產品提供形式：
    Liquid
  • 應用范圍：
    WB, ELISA
  • 推薦稀釋比：
    Application Recommended Dilution
    WB 1:500-1:2000
    ELISA 1:20000
  • Protocols：
  • 儲存條件：
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • 貨期：
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 用途：
    For Research Use Only. Not for use in diagnostic or therapeutic procedures.

產品評價

靶點詳情

  • 功能：
    Cytokine that may play a role in anterior neural induction and somite formation during embryogenesis in part through a BMP-inhibitory mechanism. Can regulate Nodal signaling during gastrulation as well as the formation and patterning of the primitive streak.
  • 基因功能參考文獻：
    1. Cerberus binds and inhibits Nodal, Activin B, BMP-6, and BMP-7 but not BMP-2 or Activin A. PMID: 26802359
    2. No significant association between the studied DKK1 variations and osteoporosis was found, while CER1 variations seem to play a significant role in the determination of osteoporosis, combined with bone markers, in postmenopausal osteoporotic women. PMID: 24138842
    3. results show that Cer1 (or CER1) serves as a good marker for quantification of definitive endoderm differentiation of mouse and human ES/iPS cells PMID: 23717584
    4. CER1 gene variations play a significant role in determining BMD and vertebral or hip fractures, which might be helpful in clinical practice to identify patients with increased fracture risk PMID: 22543871
    5. functional candidate gene for trigonocephaly PMID: 18452192
    6. successful identification of an association with CER1 in humans together with our mouse study suggests that CER1 may play a role in the development of bone or its metabolism PMID: 19113921

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  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    DAN family
  • 數據庫鏈接：

    HGNC: 1862

    OMIM: 603777

    KEGG: hsa:9350

    STRING: 9606.ENSP00000370297

    UniGene: Hs.248204



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